There are 140 million contact lens wearers worldwide. Use of contact lenses is associated with ocular inflammation (approximately 2-7% per year). We have developed novel antimicrobial coatings for contact lenses which we have shown in laboratory and animal models can reduce the ability of microbes to adhere to lenses and reduce associated inflammation. This Development project will enable us to generate proof-of-principle in a clinical cohort using existing contact lenses that have been coated u ....There are 140 million contact lens wearers worldwide. Use of contact lenses is associated with ocular inflammation (approximately 2-7% per year). We have developed novel antimicrobial coatings for contact lenses which we have shown in laboratory and animal models can reduce the ability of microbes to adhere to lenses and reduce associated inflammation. This Development project will enable us to generate proof-of-principle in a clinical cohort using existing contact lenses that have been coated using our patented processes.Read moreRead less
Improving The Safety And Quality Of Emergency Nursing Care
Funder
National Health and Medical Research Council
Funding Amount
$1,498,877.00
Summary
Failure to assess, treat comprehensively and escalate emergency patient care can be catastrophic. However, there is no emergency nursing framework in use for the 29,000+ emergency nurses working in Australia. We aim to improve access, consistency, safety and quality of emergency care for the best possible patient outcomes through system wide implementation of HIRAID - the only validated framework designed to teach emergency nurses how to systematically assess and manage emergency patients.
Immunisation Safety And Adverse Events: Improving Our Understanding Of Causes And Management
Funder
National Health and Medical Research Council
Funding Amount
$295,223.00
Summary
As the incidence of vaccine preventable diseases declines, adverse events following vaccination become increasingly important for both public and providers. This fellowship aims to improve our understanding of the risks of vaccination, potential causes, including genetic predisposition and long term clinical outcomes. A range of epidemiological, clinical and genetics studies will be performed. All these studies are targeted to understand who, what, how and why vaccine reactions occur and what ca ....As the incidence of vaccine preventable diseases declines, adverse events following vaccination become increasingly important for both public and providers. This fellowship aims to improve our understanding of the risks of vaccination, potential causes, including genetic predisposition and long term clinical outcomes. A range of epidemiological, clinical and genetics studies will be performed. All these studies are targeted to understand who, what, how and why vaccine reactions occur and what can be done to prevent or manage them better.Read moreRead less
Why Is There An Increased Risk Of Severe Adverse Perinatal Outcomes After The Use Of Clomiphene Citrate For Infertility Treatment?
Funder
National Health and Medical Research Council
Funding Amount
$570,065.00
Summary
Clomiphene citrate (CC) has been a first line treatment for female infertility internationally since the 1960’s. However, safety studies using routine prescribing practices were never performed, and numerous data sources now indicate that CC is associated with major adverse outcomes if the fetus is inadvertently exposed. We are linking prescription data to perinatal outcomes to confirm how CC is associated with adverse events so as to inform prescriber and practice change.
VACCINE SAFETY RESEARCH In Understudied And At Risk Groups: Critical Knowledge To Inform Practice And Policy.
Funder
National Health and Medical Research Council
Funding Amount
$290,041.00
Summary
Vaccines are typically given to healthy individuals and therefore safety issues loom high on the list of public concerns. Vaccine hesitancy due to safety concerns is an issue of increasing global interest and threatens to lower vaccine uptake. My research aims to understand why some people experience adverse reactions to vaccines, do genetic markers exist?, what are the long term outcomes of a vaccine reaction and how best to communicate vaccine risk/safety to the Australian community.
Near Real-time Identification Of Patient Safety Incidents Reported By Health Professionals.
Funder
National Health and Medical Research Council
Funding Amount
$324,174.00
Summary
Ten percent of admissions to Australian hospitals are associated with harm to patients. Reporting of patient safety incidents is now widespread. Current methods, which rely upon humans to manually review incident reports, do not permit timely detection of safety problems and can no longer keep up with the growing volume. This study will be the first internationally to automate the monitoring of incident reports. The outcomes have broad and immediate potential to improve the monitoring of inciden ....Ten percent of admissions to Australian hospitals are associated with harm to patients. Reporting of patient safety incidents is now widespread. Current methods, which rely upon humans to manually review incident reports, do not permit timely detection of safety problems and can no longer keep up with the growing volume. This study will be the first internationally to automate the monitoring of incident reports. The outcomes have broad and immediate potential to improve the monitoring of incidents on a local, national and international scale.Read moreRead less
Q Fever: How Common Is It And How Can We Best Prevent It? Research To Inform Q Fever Vaccine Policy In Australia And Internationally
Funder
National Health and Medical Research Council
Funding Amount
$743,376.00
Summary
Q fever is a disease of worldwide importance which has special significance for Australia where outbreaks continue to occur. We will measure the burden of Q fever in the Australian population for the first time, measure how long immunity lasts following vaccination, collect extra information on adverse events in young adults and survey knowledge and attitudes of Q fever disease and vaccine. The results will inform policies for the control of Q fever in Australia and internationally.