The Role Of Seipin In Adipocyte Development And Lipid Droplet Formation
Funder
National Health and Medical Research Council
Funding Amount
$376,258.00
Summary
The prevalence of obesity and its related disorders has reached an alarming level in Australia and other developed countries. Obesity is characterized by the accumulation of fully-differentiated adipocytes loaded with lipid droplets (LDs). We aim to characterize seipin, which regulate both lipid droplet formation and adipocyte differentiation. Results from our proposed studies may offer novel therapeutic strategies against human obesity.
The Role Of Phosphatidic Acid In Lipid Storage And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$496,169.00
Summary
The prevalence of obesity and its related disorders has reached an alarming level in Australia and other developed countries. Obesity is characterized by the accumulation of fully-differentiated adipocytes loaded with lipid droplets (LDs). We aim to examine the role of phosphatidic acid in lipid droplet formation and adipocyte differentiation. Results from our proposed studies may offer novel therapeutic strategies against human obesity and type II diabetes.
Molecular Characterization Of SEIPIN Function: Implications For Lipogenesis And Adipogenesis
Funder
National Health and Medical Research Council
Funding Amount
$767,468.00
Summary
Obesity and type II diabetes have become a major health threat to Australians. This project aims to understand how fat is made and stored. Results from this research may lead to novel therapeutic strategies against obesity and diabetes.
Exploring The Therapeutic Potential Of TRAIL In Diabetes And The Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$446,374.00
Summary
TNF-related apoptosis-inducing ligand (TRAIL) is a protein with potentially useful actions in human health and disease. TRAIL is able to prevent atherosclerosis, the cause of heart attacks and strokes. In addition, we have recently shown that its actions on fat and the pancreas may prevent the development of the metabolic syndrome and type 2 diabetes. These studies will explore the therapeutic potential of TRAIL for the prevention of diabetes and heart disease in a range of animal models.
Obesity increases the risk of developing diseases such as heart disease and type 2 diabetes, however not all obese people develop such diseases. Obese subjects with small fat cells are typically healthier than those with fewer, large fat cells. The applicants have identified a novel pathway that promotes the generation of new fat cells. This project will increase understanding of this pathway and may, ultimately, lead to new therapies that manipulate fat cell number and reduce obesity related di ....Obesity increases the risk of developing diseases such as heart disease and type 2 diabetes, however not all obese people develop such diseases. Obese subjects with small fat cells are typically healthier than those with fewer, large fat cells. The applicants have identified a novel pathway that promotes the generation of new fat cells. This project will increase understanding of this pathway and may, ultimately, lead to new therapies that manipulate fat cell number and reduce obesity related disease.Read moreRead less
The proper trafficking and storage of lipids (e.g. cholesterol and fatty acids) are crucial to human health. For instance, aberrant cellular trafficking and distribution of cholesterol is associated with heart and neurodegenerative diseases. Overwhelmed fat storage capacity can cause type II diabetes. This proposal aims to dissect the molecular mechanisms governing lipid storage and trafficking, and to provide novel therapeutic strategies against obesity, heart and neurological diseases.
The Role Of Seipin In Lipid Metabolism And Adipogenesis
Funder
National Health and Medical Research Council
Funding Amount
$397,749.00
Summary
The prevalence of obesity and its related disorders has reached an alarming level in Australia and other developed countries. Obesity is characterized by accumulation of fully-differentiated adipocytes loaded with lipid droplets (LDs). Therefore, understanding the cellular dynamics of LDs and the molecular mechanisms of adipogenesis (adipocyte differentiation) is of crucial importance in our battle against obesity. Our proposed study will help undertand the mechnisams of obesity.
Building Tissue Engineered Flaps For Surgical Reconstruction
Funder
National Health and Medical Research Council
Funding Amount
$548,453.00
Summary
As a result of serious trauma, burns or cancer surgery, large areas of new skin may be required. Of the three major skin layers - epidermal and dermal replacements are available clinically, but the third layer - the underlying fat tissue layer is yet to be developed. This project has devised a novel product to rapidly recreate the skin fat layer and additionally rapidly grow new blood vessels in these layers which will enable excellent skin coverage in all forms of major skin loss.