Inflammatory disorders a variety of pathologies, besides septicemia, infections and non-infective diseases, also are implication in metabolic disorders, such as type 2 diabetes (T2D) and hypercholesterolemia . Activin A is a protein that has important effects in inflammatory disorders. Because T2D and hypercholesterolemia have inflammatory characteristics and activin A has important effects in inflammatory disorders, it merits studying the links between activin A, T2D and hypercholesterolemia.