Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Reasons and Rationality. The project explains how we assess the truth and falsehood of everyday claims about what people have reason to do. It also explains what legitimizes our practice of praising and blaming people for their success and failure at doing what we think they have reason to do. In so doing it provides a foundation for both our ordinary practice of holding people responsible, and for the more institutionalised counterpart of this ordinary practice in the law.
The Role And Underlying Mechanisms Of Constitutional Epigenetic Silencing In Cancer Predisposition
Funder
National Health and Medical Research Council
Funding Amount
$218,617.00
Summary
Familial and young onset bowel and uterine cancer are usually caused by the inheritance of spelling mistakes in the genetic code within a set of cancer-protection genes. Recently, some patients were identified with their gene switched off by paralysing chemicals instead. This study aims to identify additional cancer cases with gene paralysis, determine if this arises in the presence or absence of a genetic change in front of the gene, and how gene paralysis is transmitted to the next generation.
Navigating New Waters: Supporting Fisheries And Aquaculture Businesses To Pursue Seafood Tourism As A Diversification Pathway
Funder
Fisheries Research and Development Corporation
Funding Amount
$135,000.00
Summary
This project is a strategic initiative to support seafood businesses in diversifying into new economic markets. Amidst evolving global challenges and the impact of Covid-19 on the seafood industry, the need for diversification is more pressing than ever. The proposed project addresses this need by providing seafood business with the necessary support and resources to diversify into a sector which boasts much potential: seafood tourism. Seafood tourism presents a practical and feasible appro .... This project is a strategic initiative to support seafood businesses in diversifying into new economic markets. Amidst evolving global challenges and the impact of Covid-19 on the seafood industry, the need for diversification is more pressing than ever. The proposed project addresses this need by providing seafood business with the necessary support and resources to diversify into a sector which boasts much potential: seafood tourism. Seafood tourism presents a practical and feasible approach to diversification, which leverages the intrigue of marine environments and the seafood production process. Whilst feasible, there are inherent challenges and risks involved in pursuing this diversification pathway. This project directly responds to the request of F&A for support in navigating the diversification process. Central to its approach, is the delivery of decision-support tools which can facilitate informed decision-making and mitigate potential risks involved in diversifying. These tools will be vital in ensuring F&A businesses make sound and strategic decisions regarding their suitability to different seafood tourism models.
Objectives: 1. Identify the range of seafood tourism business models and determine success factors for different models. 2. Document and compare the operating environment and the regulations in each jurisdiction (across production, food safety, tourism) for establishing and maintaining seafood tourism enterprises. 3. Identify the business capacity and capability needed for successful seafood businesses, inclusive of skills, assets, and networks. 4. Develop decision support tools for seafood operators to undertake a first pass assessment of the potential suitability of different tourism models. Read moreRead less
Trust and Distrust in Social Epistemic Networks. This project aims to discover critically-needed understandings of the social causes and consequences of ‘fake news’. It will do this by investigating and mapping the relationship between ‘epistemic vices’ and people’s acceptance of misinformation and disinformation (e.g. conspiracy theories). It will bring together approaches from experimental philosophy, natural language processing, social network analysis, and normative reflection to provide new ....Trust and Distrust in Social Epistemic Networks. This project aims to discover critically-needed understandings of the social causes and consequences of ‘fake news’. It will do this by investigating and mapping the relationship between ‘epistemic vices’ and people’s acceptance of misinformation and disinformation (e.g. conspiracy theories). It will bring together approaches from experimental philosophy, natural language processing, social network analysis, and normative reflection to provide new insights regarding distrust and intellectual vice, thus significantly advancing knowledge of the ‘dark side’ of social epistemology. Results will lead to urgently required guidance regarding the features of social networks that exacerbate or buffer against the manifestation of these vices.Read moreRead less
Review Of Approaches For Determining Commercial Fisheries Compensation
Funder
Fisheries Research and Development Corporation
Funding Amount
$136,420.00
Summary
WAFIC and DPIRD are seeking an improved understanding of the methods available for valuing fishery access rights, their relative advantages and disadvantages, and more specifically which methods would be most relevant and appropriate for Western Australia’s small-scale fisheries. This is to better ensure that future compensation schemes better meet their objectives while also building increased certainty and confidence for industry and the holders of access rights, which ultimately supports impr ....WAFIC and DPIRD are seeking an improved understanding of the methods available for valuing fishery access rights, their relative advantages and disadvantages, and more specifically which methods would be most relevant and appropriate for Western Australia’s small-scale fisheries. This is to better ensure that future compensation schemes better meet their objectives while also building increased certainty and confidence for industry and the holders of access rights, which ultimately supports improved resource security.
Our proposed approach draws on relevant literature and consultation with both government and fishery stakeholders (including fishers, investors, and brokers) to understand the range of approaches applied to valuing commercial fishing rights and their relative advantages and disadvantages. We will then define some key evaluation criteria that define what an appropriate compensation method is and then assess identified methods against these criteria. This evaluation will also consider how the applicability of methods may vary for different fishery types and circumstances.
The end outcome will be identification of the most appropriate valuation methods for the development of future compensation schemes for different fishery types, with a particular focus on small-scale fisheries. This advice will be developed to be readily adopted and applied by in relevant legislation and/or policy instruments.
Objectives: 1. To review and summarise methods that can be used to value fishery access rights for compensation purposes, including each method’s advantages, disadvantages and appropriateness for given circumstances. 2. To understand the views and perspectives of those that hold or trade fishery access rights regarding how they value fishery rights. 3. To identify and recommend compensation calculation approaches that are most suitable for Western Australian small-scale fisheries and that could readily be adopted in Western Australian government legislation, policy or processes. Read moreRead less
The Demands of Reason. We may reason well or badly, depending on whether we satisfy two kinds of demands. We must register all and only relevant considerations and we must respond correctly to them. But ‘the demands of reason’, as described in this project, remain inadequately understood. Drawing on work from philosophy, psychology, political and legal theory, and the social sciences, this project aims to investigate the nature, power and reach of reason’s demands. It aims to shed light on what ....The Demands of Reason. We may reason well or badly, depending on whether we satisfy two kinds of demands. We must register all and only relevant considerations and we must respond correctly to them. But ‘the demands of reason’, as described in this project, remain inadequately understood. Drawing on work from philosophy, psychology, political and legal theory, and the social sciences, this project aims to investigate the nature, power and reach of reason’s demands. It aims to shed light on what they are; whether they have the positive transformative power attributed to them by enlightenment thinkers; and whether they can be adduced to explain the nature and origin of other important normative demands, such as the demands of morality, prudence and law.Read moreRead less
Development Of An Experimental Aquaculture Facility (EAF) Specific Amoebic Gill Disease (AGD) Challenge Model That Can Reliably Evaluate Treatment Interventions To Support Industry Focused AGD Studies
Funder
Fisheries Research and Development Corporation
Funding Amount
$250,000.00
Summary
Commercial in confidence. To know more about this project please contact FRDC. Objectives: Commercial in confidence
Social Science And Economics Research Coordination Program (SSERCP) – Economic Consultant Services
Funder
Fisheries Research and Development Corporation
Funding Amount
$67,000.00
Summary
Request from Emily Ogier to sub contract Sarah Jennings for the economic component of the parent project 2015-300 Objectives: 1. To provide economic consultancy to the Social Science and Economics Research Coordination Program (SSERCP).