ACTIVATION OF ISLET INFLAMMATION BY CYTOKINE SIGNALING IN PANCREATIC BETA CELLS
Funder
National Health and Medical Research Council
Funding Amount
$406,838.00
Summary
Type 1 diabetes affects up to 4.7 million people world-wide and its incidence is increasing. It is the result of killing of insulin-producing pancreatic beta cells by cells of the immune system. This project aims to understand how immune cell invasion of the pancreas can become worse because of protein interactions that occur within beta cells, and how these cells can contribute to their own demise.
Control Of Anabolic And Catabolic Pathways By AMPK
Funder
National Health and Medical Research Council
Funding Amount
$946,402.00
Summary
This project focuses on the role of the metabolic stress-sensing enzyme AMP-activated protein kinase (AMPK) in the control of glucose and fat metabolism. AMPK has been linked to the regulation of exercise capacity, longevity and the control of insulin sensitivity. This is important for our understanding of the metabolic dimensions of our Nations most important health problems including, type-2 diabetes, cardiovascular disease, obesity, neurodegeneration as well as other age onset diseases.