People with psychotic illness, even with good treatment, do not tend to make functional recovery. They are over represented among the unemployed, the homeless, and have poorer physical health and earlier death than the general population. Despite the significant personal, societal and economic cost of these poor outcomes there has been little research into these areas. This fellowship builds on my work in vocational recovery to broaden knowledge about, and interventions for, functional recovery ....People with psychotic illness, even with good treatment, do not tend to make functional recovery. They are over represented among the unemployed, the homeless, and have poorer physical health and earlier death than the general population. Despite the significant personal, societal and economic cost of these poor outcomes there has been little research into these areas. This fellowship builds on my work in vocational recovery to broaden knowledge about, and interventions for, functional recovery in first episode psychosis.Read moreRead less
The Biophysical Basis Of HCN Channels In Human Peripheral Nerve
Funder
National Health and Medical Research Council
Funding Amount
$50,315.00
Summary
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important role as pacemakers in the cardiac and nervous systems. HCN channel dysfunction is implicated in a number of disorders including neuropathic pain and epilepsy. My aim is to determine the kinetics and voltage dependence of HCN channels in human peripheral nerve in vivo. Understanding these channels is a prerequisite to the development of safe targeted therapies against neuropathic pain.