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Investigating A Potential New Treatment For Stroke
Funder
National Health and Medical Research Council
Funding Amount
$878,522.00
Summary
Blood clots blocking blood flow to the brain (stroke) are a major cause of death and disability. Safety concerns limit approved therapies to a small subset of patients, highlighting an urgent need for safer, more effective drugs. Our studies show that inhibitors of the enzyme PI3Kbeta increase blood clot permeability, increasing clot ‘dissolvability’, without increased bleeding. This raises the possibility that PI3Kbeta inhibitors may represent a safe and effective adjuvant therapy for stroke.
Investigating The Mechanisms And Preventative Strategies To Alleviate The Burden Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$640,210.00
Summary
My research seeks to examine (i) the role of lifestyle, diet, physical activity, alcohol consumption and psychosocial factors, on risk factors for heart disease and stroke; (ii) elucidate the underlying mechanisms; and (iii) examine the developmental origins of heart disease and stroke within the Western Australian Pregnancy Cohort (Raine) Study, which is one of the largest longest running longitudinal pregnancy studies in the world.
Prof Trevor Mori has held an NH&MRC Research Fellowship during 2008-2012. This grant will enable him to continue his research program into 2013-2017. Prof Mori is a biomedical research scientist. His research examines the role of diet and lifestyle on risk factors for cardiovascular disease. He also leads the cardiometabolic team examining risk factors in the Western Australian Pregnancy (Raine) Study.