Bacterial Proteomics: From Cell Division to Novel Antibiotic Targets. When a cell divides it is essential that each newborn cell gets a complete copy of the DNA. To ensure that this happens, cell division must be tightly controlled. It is not known how this occurs in bacteria. However, if we knew what molecules were involved in this control, we could target them to kill harmful bacteria. This project aims to identify such regulatory molecules as candidate targets for antimicrobial agents, with a ....Bacterial Proteomics: From Cell Division to Novel Antibiotic Targets. When a cell divides it is essential that each newborn cell gets a complete copy of the DNA. To ensure that this happens, cell division must be tightly controlled. It is not known how this occurs in bacteria. However, if we knew what molecules were involved in this control, we could target them to kill harmful bacteria. This project aims to identify such regulatory molecules as candidate targets for antimicrobial agents, with a view to developing powerful, novel antibiotics to protect us from the imminent threat of bioterrorism and antibiotic-resistant bacteria.
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Tertiary education and social capital in Victoria: the effects of the new economy courses in Business and IT. Over one third of tertiary students are enrolled in the fast-growing new economy disciplines in business studies and IT. In partnership with the Victorian government, this project studies the contribution of business and IT courses to social capital, the collaborative networks that underpin economic innovation and sustainable community. The research will survey and interview Victorian 15 ....Tertiary education and social capital in Victoria: the effects of the new economy courses in Business and IT. Over one third of tertiary students are enrolled in the fast-growing new economy disciplines in business studies and IT. In partnership with the Victorian government, this project studies the contribution of business and IT courses to social capital, the collaborative networks that underpin economic innovation and sustainable community. The research will survey and interview Victorian 1500 graduates from 12 higher education and VET institutions (6 rural); and survey and interview employers and community leaders. The research will inform Victoria's education policy and Growing Victoria Together strategy, and encourage tertiary institutions throughout Australia to strengthen their contribution to social capital.Read moreRead less
Bacterial Cell Division: Discovering how it begins and the network of protein interactions it requires. All cells must coordinate cell division with chromosome replication to ensure that the DNA is partitioned equally into newborn cells. We will establish the defect of a novel mutant blocked in the earliest stage of cell division in bacteria to obtain unique information about this vital regulatory step. We will use our newly discovered protein interaction network to establish what role protein i ....Bacterial Cell Division: Discovering how it begins and the network of protein interactions it requires. All cells must coordinate cell division with chromosome replication to ensure that the DNA is partitioned equally into newborn cells. We will establish the defect of a novel mutant blocked in the earliest stage of cell division in bacteria to obtain unique information about this vital regulatory step. We will use our newly discovered protein interaction network to establish what role protein interactions play in integrating cell division with other biological pathways in the cell to ensure its tight regulation. Our discoveries will facilitate the design of new antibiotics that target cell division to fight antibiotic-resistant bacteria and bioterrorism organisms.Read moreRead less
Recruit to Retain: From Medical School to Rural Practitioner. In order to make use of assets and resources the Government is providing for medical training and to address the problem of inequitable distribution of GPs in Australia this project aims to develop a theoretical yet practical understanding of the personal attributes of medical students, residents, registrars and general practitioners that are directly applicable to their recruitment and retention into rural practice. Application of th ....Recruit to Retain: From Medical School to Rural Practitioner. In order to make use of assets and resources the Government is providing for medical training and to address the problem of inequitable distribution of GPs in Australia this project aims to develop a theoretical yet practical understanding of the personal attributes of medical students, residents, registrars and general practitioners that are directly applicable to their recruitment and retention into rural practice. Application of this theoretical perspective will inform and help modify existing training for medical professionals at all levels who have opted for a rural pathway in order to better equip and retain them for life in rural practice.Read moreRead less
E-Learning Advocacy : Understanding Students' Experience of New Learning Environments to Promote Quality Sustainable Developments. Increasing investment in new learning environments (NLEs) including e-learning is guided by limited empirical research. Learning in NLEs involves more than a set of skills - it requires a new mindset. This project will delineate the different opportunities and demands, the nature and development of undergraduate students' experiences of NLEs and compare those with eq ....E-Learning Advocacy : Understanding Students' Experience of New Learning Environments to Promote Quality Sustainable Developments. Increasing investment in new learning environments (NLEs) including e-learning is guided by limited empirical research. Learning in NLEs involves more than a set of skills - it requires a new mindset. This project will delineate the different opportunities and demands, the nature and development of undergraduate students' experiences of NLEs and compare those with equivalent programs taught in more traditional ways. Major outcomes involve understanding learners' experiences when engaging in ICT settings, and an understanding of the mutual constructions of the experience. Such understanding will inform development of e-learning programs and the nature of support necessary for optimising learning.Read moreRead less
Virtual Reality Training Kit for Arc Welders. The aim of this research is to develop a virtual reality training package that enables welders to obtain basic manipulative skills in a safe environment before they are exposed to additional welding hazards. The research addresses the problem of welder training in a novel manner by utilizing a virtual reality simulator to allow the welding trainee to develop his manipulative and functional skills prior to attempting real welding tasks. An additional ....Virtual Reality Training Kit for Arc Welders. The aim of this research is to develop a virtual reality training package that enables welders to obtain basic manipulative skills in a safe environment before they are exposed to additional welding hazards. The research addresses the problem of welder training in a novel manner by utilizing a virtual reality simulator to allow the welding trainee to develop his manipulative and functional skills prior to attempting real welding tasks. An additional feature of the package is the internetworking facility that will allow monitoring and feedback of results to trainers. This is an advantage especially for remote communitiesRead moreRead less
Theory and applications of Bayesian and likelihood analyses for finite mixture, random effect and multinomial models. The expected outcomes of the project are: to establish the scientific
value of modern Bayesian methods for statistical inference in a wider
range of applications than previously available, to contribute to the greater unification of the current theories of statistical inference which are to some extent in conflict, and to provide a set of Bayesian analytic tools implemented in ....Theory and applications of Bayesian and likelihood analyses for finite mixture, random effect and multinomial models. The expected outcomes of the project are: to establish the scientific
value of modern Bayesian methods for statistical inference in a wider
range of applications than previously available, to contribute to the greater unification of the current theories of statistical inference which are to some extent in conflict, and to provide a set of Bayesian analytic tools implemented in widely available, free and open-source statistical software.
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Establishing how bacterial cells position the division site. Cell division is essential for life. It is required for bacterial infections and, if uncontrolled, causes diseases such as cancer. We will establish how bacterial cells position the division site precisely to ensure faithful production of newborn cells. We will use the latest technology in bacterial cell biology to provide novel, clear-cut information to maintain Australia at the leading edge of this important area of research. There i ....Establishing how bacterial cells position the division site. Cell division is essential for life. It is required for bacterial infections and, if uncontrolled, causes diseases such as cancer. We will establish how bacterial cells position the division site precisely to ensure faithful production of newborn cells. We will use the latest technology in bacterial cell biology to provide novel, clear-cut information to maintain Australia at the leading edge of this important area of research. There is an alarming increase in antibiotic resistant bacteria and an imminent threat of bioterrorism. This research allows the opportunity for the development of new antibiotics to protect Australia protected from these dangerous bacteria. Read moreRead less
One coordinate carbon and boron: Universal progenitor ligands. Compounds with bonds between metals and carbon (organometallic chemistry) underpin innumerable important industrial processes from fine chemicals to bulk agrochemical and polymer synthesis. Yet the simplest example, a single atom of carbon bound to a metal has only recently been discovered and is poorly understood. Australia's fledgling boron fine chemicals industry similarly benefits from metal-based processes. However, compounds wi ....One coordinate carbon and boron: Universal progenitor ligands. Compounds with bonds between metals and carbon (organometallic chemistry) underpin innumerable important industrial processes from fine chemicals to bulk agrochemical and polymer synthesis. Yet the simplest example, a single atom of carbon bound to a metal has only recently been discovered and is poorly understood. Australia's fledgling boron fine chemicals industry similarly benefits from metal-based processes. However, compounds with a single boron atom bound to a metal remain unknown. This proposal addresses metal-carbon and metal-boron chemistry from the most basic perspective, that of a single atom of boron or carbon, including the development of novel synthetic approaches and skills for the characterisation of such curious species.Read moreRead less
Regulating the earliest step in bacterial cell division: Z ring assembly. Cell division is essential for survival. What are the cues that signal cells to divide at the right place and at the right time? How do cells ensure that when division occurs to produce two newborn cells, each one receives the correct amount of DNA? The answers to these questions are essential to understand how organisms reproduce and grow. But they remain unknown. This research addresses these questions in bacteria. Our d ....Regulating the earliest step in bacterial cell division: Z ring assembly. Cell division is essential for survival. What are the cues that signal cells to divide at the right place and at the right time? How do cells ensure that when division occurs to produce two newborn cells, each one receives the correct amount of DNA? The answers to these questions are essential to understand how organisms reproduce and grow. But they remain unknown. This research addresses these questions in bacteria. Our discoveries will have a significant impact on our understanding of the regulation of this vital process and will facilitate the design of novel antibiotics that target it.Read moreRead less