New biosensing strategies based on bipolar electrochemiluminescence. Chemical analysis is a vital activity in our society, which is to a large extent confined to scientific laboratories and carried out with complex instrumentation. The breakthrough technology envisioned in this proposal will pave the way for simple, low-cost tests which can be used by non-scientists. The development of small, portable sensors for applications ranging from pollution monitoring to health testing, will enable ordi ....New biosensing strategies based on bipolar electrochemiluminescence. Chemical analysis is a vital activity in our society, which is to a large extent confined to scientific laboratories and carried out with complex instrumentation. The breakthrough technology envisioned in this proposal will pave the way for simple, low-cost tests which can be used by non-scientists. The development of small, portable sensors for applications ranging from pollution monitoring to health testing, will enable ordinary people to gain knowledge about the concentrations of molecular compounds in their environments and in themselves. This will stimulate economic and social benefits related to environmental testing and early disease diagnosis and generate new commercial opportunities for the Australian biotechnology industry.Read moreRead less
Development of ozone-induced dissociation for lipidomics workflows. An Australian invention (ozone induced dissociation) will be developed in collaboration with a major instrument manufacturer. This project will provide Australian researchers with unique capabilities to investigate the role of lipids (fats) in human disease and will place them at the forefront of lipid research internationally.
Discovery Early Career Researcher Award - Grant ID: DE120100467
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Unravelling the intrinsic structure and stability of multiply charged anions in the gas-phase using photoelectron spectroscopy and mass spectrometry. Molecules possessing multiple negative charges are common constituents in chemistry, influencing a range of processes ranging from photochemical smog formation to protein structure in vivo. This project will develop new technologies to probe their molecular structure in the gas-phase, leading to a more rigorous understanding of these species.
New laser and mass spectrometry-based tools for comprehensive structural elucidation of lipids and their biomolecular interactions. Lipid-related disorders such as obesity, diabetes and heart disease are reaching epidemic proportions. We propose the development of specialised instrumentation to identify and quantify lipids (fats) in tissue and culture samples thus providing Australian scientists with unique capabilities to investigate the mechanisms of disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100059
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
Multiplexed capabilities for surface analysis and imaging by mass spectrometry. This facility will support research aimed at developing rapid and reliable analytical methods for the detection of chemicals directly from biological and man-made materials. The mass spectroscopy methods used at the facility will reveal molecular-level changes in systems ranging from the lens of the human eye to Colorbond steel® and have applications in the detection of chemical and biological hazards.
Integration of DNA switches into wearables for smart chemical monitoring. This project addresses the scientific challenge of real-time monitoring of dynamic biological changes in the secretions found in sweat. By creating a wearable wireless device to monitor chemicals which interests Nutromics, using a novel electronic skin technology platform, the work aims to generate new knowledge of physiological changes in sweat secretions. Lying at the interface of analytical chemistry, functional materia ....Integration of DNA switches into wearables for smart chemical monitoring. This project addresses the scientific challenge of real-time monitoring of dynamic biological changes in the secretions found in sweat. By creating a wearable wireless device to monitor chemicals which interests Nutromics, using a novel electronic skin technology platform, the work aims to generate new knowledge of physiological changes in sweat secretions. Lying at the interface of analytical chemistry, functional materials and biomedical engineering, the project will contribute to the training of young researchers in these emerging technologies which interest Nutromics Pty Ltd. The project will improve Australia's standing in technology around wearable devices, improving our global competitive edge with economic and scientific impact.Read moreRead less
New hyphenated chromatographic and spectroscopic methods for oil analysis. This project aims to use novel chemical separation methods combined with spectroscopy to identify useful markers in olive oil and essential oil to ensure purity, quality and authenticity, which are all ongoing issues in these industries in Australia and overseas. The project plans to compare and integrate results of multidimensional gas chromatography combined with mass spectrometry and Fourier transform infrared analyses ....New hyphenated chromatographic and spectroscopic methods for oil analysis. This project aims to use novel chemical separation methods combined with spectroscopy to identify useful markers in olive oil and essential oil to ensure purity, quality and authenticity, which are all ongoing issues in these industries in Australia and overseas. The project plans to compare and integrate results of multidimensional gas chromatography combined with mass spectrometry and Fourier transform infrared analyses with data libraries to generate precise molecular identification. The outcome is expected to help monitor adulteration of oils and maintain the high quality standards of Australian produce.Read moreRead less
3D printed microchemical devices and systems. This project aims to address the barriers faced by 3D printing in chemistry. 3D printing can create bespoke 3D structures within a fraction of time and cost compared to traditional fabrication. However, its scope in chemistry has been limited by the poor chemical robustness, biotoxicity and low resolution of the 3D printed components. Hence, this project will develop novel gold coating techniques and explore high-resolution 3D printing to overcome th ....3D printed microchemical devices and systems. This project aims to address the barriers faced by 3D printing in chemistry. 3D printing can create bespoke 3D structures within a fraction of time and cost compared to traditional fabrication. However, its scope in chemistry has been limited by the poor chemical robustness, biotoxicity and low resolution of the 3D printed components. Hence, this project will develop novel gold coating techniques and explore high-resolution 3D printing to overcome these challenges. The project should generate commercially significant products (analytical platforms), technology (gold coating) and patents. The developed systems and technologies will address Australian research challenges in advanced manufacturing and enable on-site environmental monitoring.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100213
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Advanced fluorescence characterisation facility. Fluorescence is the emission of light by a substance that has absorbed light of a different wavelength. Fluorescence techniques and fluorescent molecules have enabled a great many of the most important advances in biology, chemistry and medicine in recent decades. This facility will support a wide range of research projects using or exploring fluorescence and luminescence. The research supported will underpin advances in diverse scientific fields.
Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagn ....Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagnostics, forensic sample determination and industrial process monitoring through decreased analysis time with an increase in the chemical information gained. By performing chemical separations on a microfluidic scale a reduction in both the cost of analysis and impact of solvent waste on the environment will be achieved.Read moreRead less