Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100036
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
A customised triple-beam microscope for precise fabricating/characterising . This project aims to establish a customised triple-beam microscope to enable precise fabrication and polishing (using ion beams) and characterisation (using electron beam) of a wide range of advanced materials. It will provide solutions to prepare ultra-high quality and artefact-free specimens for transmission electron microscopy studies, and allow fabrication of unique nanostructures and nanostructured templates for hi ....A customised triple-beam microscope for precise fabricating/characterising . This project aims to establish a customised triple-beam microscope to enable precise fabrication and polishing (using ion beams) and characterisation (using electron beam) of a wide range of advanced materials. It will provide solutions to prepare ultra-high quality and artefact-free specimens for transmission electron microscopy studies, and allow fabrication of unique nanostructures and nanostructured templates for high-performance applications. The customised features of the proposed instrument are the first of its kind in Australia. The new knowledge developed through this project will significantly impact on scientific insights and practical applications of new materials related to physics, chemistry, biology, geology and engineering.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100035
Funder
Australian Research Council
Funding Amount
$4,958,927.00
Summary
ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, ....ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, providing the materials and inspiration for young researchers to apply novel hyphenated methods to complex environmental and industrial systems. This Centre will deliver fundamental developments in hyphenated technologies, new analytical capability, and applied outcomes across multiple end-user groups and interests. Read moreRead less
A New Nano Tip Fabrication Technique for Atomic Force Microscopy. This project aims to develop a new fabrication technique for high-aspect-ratio (long and sharp) tips for atomic force microscopy. The technique is expected to overcome the current fabrication limitation, that is fabricating one tip at a time which is unsuitable for batch fabrication. The proposed technique can be scaled up to mass produce nano tips. The technique is expected to create new commercial products and intellectual prope ....A New Nano Tip Fabrication Technique for Atomic Force Microscopy. This project aims to develop a new fabrication technique for high-aspect-ratio (long and sharp) tips for atomic force microscopy. The technique is expected to overcome the current fabrication limitation, that is fabricating one tip at a time which is unsuitable for batch fabrication. The proposed technique can be scaled up to mass produce nano tips. The technique is expected to create new commercial products and intellectual property. This innovation will lead to the emergence of breakthrough technologies in nanofabrication and nanomaterials synthesis. The benefits to Australia include new job opportunities and the development of local expertise in the field.Read moreRead less
Role of water in earth and planetary evolution. This project aims to understand the role of water in the building of our solar system, Mars and Earth. Surprisingly little is known about key issues surrounding the origin of water and its subsequent recycling on Earth. This project will use new techniques for measuring low abundances of water along with oxygen isotopes, to measure water abundances and oxygen isotopes in meteorites and terrestrial rocks to establish how water was delivered to Earth ....Role of water in earth and planetary evolution. This project aims to understand the role of water in the building of our solar system, Mars and Earth. Surprisingly little is known about key issues surrounding the origin of water and its subsequent recycling on Earth. This project will use new techniques for measuring low abundances of water along with oxygen isotopes, to measure water abundances and oxygen isotopes in meteorites and terrestrial rocks to establish how water was delivered to Earth and to understand how water is geologically recycled. This is expected to have direct bearing on where and how Earth's water originated, how water is retained in mantle and crustal minerals and it will have broad implications for understanding volcanic hazards and formation of ore deposits. This will lead to a new capability for combined water and oxygen isotope analysis in Australian geoscience leading to technological development and commercialisation of instrumentation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100060
Funder
Australian Research Council
Funding Amount
$638,853.00
Summary
High speed multi modal in-situ Transmission Electron Microscopy platform. This project aims to establish an in situ transmission electron microscope that will allow the atomic scale imaging of materials, while simultaneously measuring physical, chemical, electrical and optical properties, using a novel combination of cutting edge in-situ sample holders and an instrument mounted laser system. The instrument will be optimised for imaging of dynamic phenomena and the combination of spatial resoluti ....High speed multi modal in-situ Transmission Electron Microscopy platform. This project aims to establish an in situ transmission electron microscope that will allow the atomic scale imaging of materials, while simultaneously measuring physical, chemical, electrical and optical properties, using a novel combination of cutting edge in-situ sample holders and an instrument mounted laser system. The instrument will be optimised for imaging of dynamic phenomena and the combination of spatial resolution in the picometre scale, with microsecond level temporal resolution will be unique. The instrument will accelerate research into hydrogen production and carbon dioxide transformation, and thus support Australia's move to a more sustainable economy. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100010
Funder
Australian Research Council
Funding Amount
$928,291.00
Summary
Single-molecule Manipulation and Interaction Facility (SMIF). This LIEF project aims to establish Australia's first Single-molecule Manipulation and Interaction Facility (SMIF), providing multidisciplinary researchers with a platform to explore cellular processes and reveal molecular mechanisms at the nanoscale. The SMIF facility incorporates cutting-edge technologies for bio-manipulation, real-time visualisation, and characterisation of single-molecule interactions, overcoming the technical com ....Single-molecule Manipulation and Interaction Facility (SMIF). This LIEF project aims to establish Australia's first Single-molecule Manipulation and Interaction Facility (SMIF), providing multidisciplinary researchers with a platform to explore cellular processes and reveal molecular mechanisms at the nanoscale. The SMIF facility incorporates cutting-edge technologies for bio-manipulation, real-time visualisation, and characterisation of single-molecule interactions, overcoming the technical complexity of traditional tools requiring highly specialised personnel. By offering accessible, easy-to-use advanced systems, this project will significantly boost scientific discovery across physics, chemistry, and biology, fostering collaboration and innovation to better understand life at the molecular level.Read moreRead less
ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reac ....ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reactions and how higher brain function emerges from networks of neurons. By building a diverse, multidisciplinary, and industry-engaged ecosystem, the Centre means to develop our future leaders at the interface of quantum science and biology and drive Australian innovation across manufacturing, energy, agriculture, health, and national security.Read moreRead less
Noise-free Cryogenic Wavefront Sensing. This project aims to optimise the prototype adaptive optics technology for the Giant Magellan Telescope (GMT) by leveraging past investment in adaptive optics instrumentation and shortwave infrared detector systems. This project expects to generate significant improvements in GMT performance, with ten times greater image resolution than the Hubble Space Telescope and current estimates of >90% sky coverage, compared with ~50% coverage for current technology ....Noise-free Cryogenic Wavefront Sensing. This project aims to optimise the prototype adaptive optics technology for the Giant Magellan Telescope (GMT) by leveraging past investment in adaptive optics instrumentation and shortwave infrared detector systems. This project expects to generate significant improvements in GMT performance, with ten times greater image resolution than the Hubble Space Telescope and current estimates of >90% sky coverage, compared with ~50% coverage for current technology. Expected outcomes of this project include the development of a highly trained workforce and continued international collaboration in the field of high-technology sensor systems. This contribution to the GMT will provide significant benefits—it will change the way we view the Universe.Read moreRead less