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Towards early detection of upper airway obstruction in children: investigation of autonomic control. This project focuses on the investigation of new indicators for early detection of upper airway obstruction (UAO)-which is a common sleep disorder in children. Failure to treat UAO can result in serious adverse outcomes including failure to thrive, neurocognitive deficits, developmental delay, behavioural disorders and cardiovascular disease. Thus, early treatment of UAO will significantly improv ....Towards early detection of upper airway obstruction in children: investigation of autonomic control. This project focuses on the investigation of new indicators for early detection of upper airway obstruction (UAO)-which is a common sleep disorder in children. Failure to treat UAO can result in serious adverse outcomes including failure to thrive, neurocognitive deficits, developmental delay, behavioural disorders and cardiovascular disease. Thus, early treatment of UAO will significantly improve quality of life for the child. Direct benefits to community health via reduced costs for medical treatment will also be a key outcome. The establishment of new diagnostic indicators will form the basis of new tools for identifying child sleep disorders and contribute to advancing Australia's international leading position in health technology. Read moreRead less
Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery. The project aim is to develop a state of the art technology for the efficient, reliable and economical production of nanoparticles of drugs suitable for inhalation delivery to the lung. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. The project will focus on both the production process and the particle properties for aerosol a ....Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery. The project aim is to develop a state of the art technology for the efficient, reliable and economical production of nanoparticles of drugs suitable for inhalation delivery to the lung. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. The project will focus on both the production process and the particle properties for aerosol administration. Successful development of the technology will not only gain new knowledge in the key area of nanotechnology, but also lead to better inhalation therapy to benefit patients.Read moreRead less
Domestic air quality: towards the setting of guidelines. Air quality standards have been developed to protect human health. Although people spend most of their time indoors there are no standards and only a few guidelines for indoor air pollution (IAP). The aim of this study is to investigate the levels of IAP that may worsen asthma in children. Childhood asthma will be used as a health indicator due to its high prevalence, cost to the healthcare system and implications for respiratory morbidity ....Domestic air quality: towards the setting of guidelines. Air quality standards have been developed to protect human health. Although people spend most of their time indoors there are no standards and only a few guidelines for indoor air pollution (IAP). The aim of this study is to investigate the levels of IAP that may worsen asthma in children. Childhood asthma will be used as a health indicator due to its high prevalence, cost to the healthcare system and implications for respiratory morbidity in adult life. We expect to identify levels of IAP that will represent a health risk as well as the factors that may contribute to increased IAP in homes.Read moreRead less
Engineering of composite particles to enhance performance in respiratory drug delivery. Respiratory conditions such as asthma and chronic pulmonary disease affect in excess of 5.8 million Australians and the common method of treatment is via drug inhalation. Although a wide range of drugs are commercially available as dry powder inhalers the efficiency of these systems is poor, with most devices delivering less than 20% to the lung. This project will develop a new method of high-efficiency respi ....Engineering of composite particles to enhance performance in respiratory drug delivery. Respiratory conditions such as asthma and chronic pulmonary disease affect in excess of 5.8 million Australians and the common method of treatment is via drug inhalation. Although a wide range of drugs are commercially available as dry powder inhalers the efficiency of these systems is poor, with most devices delivering less than 20% to the lung. This project will develop a new method of high-efficiency respiratory drug delivery based on composite particles. The technology developed from this project will advance Australia’s Research & Innovation and Pharmaceutical industry sector, and improve healthcare outcomes in the government’s key priority area of Promoting and maintaining good health: ‘A healthy start to life’ and ‘Ageing well’Read moreRead less
The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery. This project provides a unique opportunity to develop an Australian-invented technology in particle engineering, enabling it to enter the international pharmaceutical market. This will enhance the growth of Australia's pharmaceutical research and development, and benefit the Australian pharmaceutical industry. The outcome will also contribute to improvements in the heal ....The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery. This project provides a unique opportunity to develop an Australian-invented technology in particle engineering, enabling it to enter the international pharmaceutical market. This will enhance the growth of Australia's pharmaceutical research and development, and benefit the Australian pharmaceutical industry. The outcome will also contribute to improvements in the health and well-being of Australians. The research falls within the Designated National Research Priority of Frontier Technologies for Building and Transforming Australian Industries.Read moreRead less
Dispersion of Pharmaceutical Powders as Aerosols for Inhalation. The detrimental environmental effects of chlorofluorocarbons (CFC) have led to an urgent need of a replacement for the existing CFC propellant driven medical inhalers. Generation of aerosols from dry powders has enormous potential as an alternative for delivery of drugs to the lung. The aims of the proposed research are to investigate specifically the powder surface properties and the orperating conditions on the dispersion of po ....Dispersion of Pharmaceutical Powders as Aerosols for Inhalation. The detrimental environmental effects of chlorofluorocarbons (CFC) have led to an urgent need of a replacement for the existing CFC propellant driven medical inhalers. Generation of aerosols from dry powders has enormous potential as an alternative for delivery of drugs to the lung. The aims of the proposed research are to investigate specifically the powder surface properties and the orperating conditions on the dispersion of powders as aerosols for inhalation. The knowledge gained will acclerate the design of better powder aerosols, thus benefiting patients suffering from respiratory and systemic diseases.Read moreRead less
Special Research Initiatives - Grant ID: SR0563610
Funder
Australian Research Council
Funding Amount
$111,115.00
Summary
Developing an E-Platform for Application of Clinical Management in the Human Respiratory and Vascular System. This project aims to develop an E-PLATFORM that will provide a simulation-based virtual reality environment for clinical management and therapy treatment in the human respiratory and vascular system. One significant feature of the expected outcomes is the ability for surgeon or physician to adequately plan their treatment or operation decision-making of respiratory or vascular disease, i ....Developing an E-Platform for Application of Clinical Management in the Human Respiratory and Vascular System. This project aims to develop an E-PLATFORM that will provide a simulation-based virtual reality environment for clinical management and therapy treatment in the human respiratory and vascular system. One significant feature of the expected outcomes is the ability for surgeon or physician to adequately plan their treatment or operation decision-making of respiratory or vascular disease, in particular, from the point of view of flow analysis using state-of-the-art computational fluid dynamics techniques. This research proposal aims to facilitate new medical research and development for treatment of respiratory and/or vascular diseases, which can have a great socioeconomic benefit to the Australian community.Read moreRead less
Cardiovascular and Respiratory Activity During Sleep Onset. Going to sleep requires that behavioural and physiological activities be modified. This is achieved by the integrated activity of sleep mechanisms and the circadian system. In this project we will investigate the nature of the regulatory control exerted by sleep mechanisms over respiration and cardiovascular activity at sleep onset, how sleep control interacts with circadian influence, and the nature of cardio-respiratory activity when ....Cardiovascular and Respiratory Activity During Sleep Onset. Going to sleep requires that behavioural and physiological activities be modified. This is achieved by the integrated activity of sleep mechanisms and the circadian system. In this project we will investigate the nature of the regulatory control exerted by sleep mechanisms over respiration and cardiovascular activity at sleep onset, how sleep control interacts with circadian influence, and the nature of cardio-respiratory activity when sleep control is removed at an arousal from sleep. It is anticipated that a better understanding of the regulatory control exerted by sleep over other systems will improve our understanding of sleep disorders.Read moreRead less
Improving asthma device use: Innovative models for inter-professional practice. This project falls within the goals of National Priority 2: promoting and maintaining good health. This project has the potential to affect every individual accessing health care in the Australia. Through its approach to and focus on improving the use of asthma medications this project will impact on: the quality use of medicines and health outcomes for patients. Through its focus on health professional relationships ....Improving asthma device use: Innovative models for inter-professional practice. This project falls within the goals of National Priority 2: promoting and maintaining good health. This project has the potential to affect every individual accessing health care in the Australia. Through its approach to and focus on improving the use of asthma medications this project will impact on: the quality use of medicines and health outcomes for patients. Through its focus on health professional relationships and interdisciplinary approach to community health care it will result in: improved interprofessional relationships and a model of collaboration which has the potential to be implemented on a broad scale in the community.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560661
Funder
Australian Research Council
Funding Amount
$245,300.00
Summary
Particulate Characterisation for Pharmaceutical and Engineering Applications. The aim of this proposal is to establish joint facilities between the University of Sydney, Monash University and UNSW for the characterization of surface properties and particle sizes of pharmaceutical aerosols and industrial powders. Such knowledge is important for controlling aerosol production and delivery of drug particles to the lungs. This will have a significant benefit to the pharmaceutical industry and patien ....Particulate Characterisation for Pharmaceutical and Engineering Applications. The aim of this proposal is to establish joint facilities between the University of Sydney, Monash University and UNSW for the characterization of surface properties and particle sizes of pharmaceutical aerosols and industrial powders. Such knowledge is important for controlling aerosol production and delivery of drug particles to the lungs. This will have a significant benefit to the pharmaceutical industry and patients requiring aerosol treatment. Further, the proposed facilities will enhance research in complex particulate processes and modelling, functional nanomaterials, and soft sensor development, thus keeping Australia at the forefront of powder research into various high value adding particulate areas.Read moreRead less