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Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vesse ....Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vessels influence the function of the kidney. This will lead to predictive models to aid the design and interpretation of physiological studies and the combat of hypertension. It will also help in the ongoing development of bioartificial kidneys to replace present dialysis systems. Read moreRead less
FLOW STUDIES OF CELL CULTURE BIOREACTORS. The proposed research program consists of a number of stages, amongst which is the study of flows within mixed flasks, the study of a small-scale Taylor-Couette vessel, and the development of a three-dimensional Holographic Particle Image Velocimetry flow measurement system. A successful project will be a valuable contribution to the development of cell and tissue scale up systems. In the long term, such systems will potentially provide the means of grow ....FLOW STUDIES OF CELL CULTURE BIOREACTORS. The proposed research program consists of a number of stages, amongst which is the study of flows within mixed flasks, the study of a small-scale Taylor-Couette vessel, and the development of a three-dimensional Holographic Particle Image Velocimetry flow measurement system. A successful project will be a valuable contribution to the development of cell and tissue scale up systems. In the long term, such systems will potentially provide the means of growing cell and tissue in quantities suitable for implantation or use in other therapeutic applications that are currently deemed impossible.Read moreRead less
Discovery Indigenous Researchers Development - Grant ID: DI0989521
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A Qualitative Study of Barriers to Effective Infectious and Parasitic Disease Interventions in Aboriginal Communities. This project is significant and innovative as it will enhance current understandings of the experience Indigenous communities have with infectious diseases. To date there have been no significant qualitative studies that examine the perceptions Indigenous communities have about infectious disease treatment interventions that draw on their current knowledge, experiences and on he ....A Qualitative Study of Barriers to Effective Infectious and Parasitic Disease Interventions in Aboriginal Communities. This project is significant and innovative as it will enhance current understandings of the experience Indigenous communities have with infectious diseases. To date there have been no significant qualitative studies that examine the perceptions Indigenous communities have about infectious disease treatment interventions that draw on their current knowledge, experiences and on health, functionality and well-being. This study will develop a model that Indigenous communities, clinicians, policy makers and researchers can use to guide the implementation of sustainable infectious disease interventions. The outcomes of this project will help guide, inform and improve future infectious disease intervention strategies and programs.Read moreRead less
Planning and Building Healthy Communities: A multidisciplinary longitudinal study of the relationship between the built environment and human health. This project examines how urban environments support health. Tracking residents’ behaviours over a long time, the study fills a gap in current knowledge about how urban environments manage and promote good health (a national research priority area). It will identify the design features, social interventions and locational qualities in selected sit ....Planning and Building Healthy Communities: A multidisciplinary longitudinal study of the relationship between the built environment and human health. This project examines how urban environments support health. Tracking residents’ behaviours over a long time, the study fills a gap in current knowledge about how urban environments manage and promote good health (a national research priority area). It will identify the design features, social interventions and locational qualities in selected sites which positively benefit human health. The research will describe the likely health outcomes for future Australians living in areas with similar characteristics. It will also strengthen multidisciplinary approaches and policy development in this area by bringing together a team from urban planning, development and health.Read moreRead less
Examining organisational complexity and clinical risk to improve hospital patients' safety. Improving communicative practices will reduce the massive rate and cost of medication errors and hospital-acquired infections. Current costs of hospital-caused incidents are around AU$2 billion per year. These costs are likely to rise further because hospitals are becoming busier, more culturally and linguistically diverse, less generously resourced per patient, and more technologically capable of keeping ....Examining organisational complexity and clinical risk to improve hospital patients' safety. Improving communicative practices will reduce the massive rate and cost of medication errors and hospital-acquired infections. Current costs of hospital-caused incidents are around AU$2 billion per year. These costs are likely to rise further because hospitals are becoming busier, more culturally and linguistically diverse, less generously resourced per patient, and more technologically capable of keeping sicker patients alive for longer, leading to increased clinical risk and more incidents. This project could save around 20% of the total cost of hospital operations by reducing lengths of stay, lowering re-admission rates and ensuring better deployment of clinical resources.Read moreRead less
Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities ....Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities to address current limitations in understanding the stability of magnetic nanoparticles in biological fluids. The Australian partners will play a leading role in commercializing new applications for functionalized magnetic nanoparticles. The project will provide an excellent multidisciplinary research environment and training for early career researchers.Read moreRead less
Development of improved technologies for high throughput screening of potential disease susceptibility genes. This research is aimed at developing more efficient strategies to identify genes involved in common, human disorders. We aim to develop cost-effective, high throughput approaches for DNA extraction and preparation, accurately determining DNA concentration and quality and for undertaking extensive polymorphism genotyping and analysis. The suitability of equipment, analysis packages and so ....Development of improved technologies for high throughput screening of potential disease susceptibility genes. This research is aimed at developing more efficient strategies to identify genes involved in common, human disorders. We aim to develop cost-effective, high throughput approaches for DNA extraction and preparation, accurately determining DNA concentration and quality and for undertaking extensive polymorphism genotyping and analysis. The suitability of equipment, analysis packages and software, will be assessed and better technologies and packages developed. The study involves collaboration between a research centre with considerable expertise in molecular genetics and Corbett Research, a leader in the field of molecular equipment production. The development of better gene screening technologies has both molecular and commercial significance.Read moreRead less
The Effects of Nano and Ultrafine Particles from Traffic Emissions on Children's Health. The socio-economic benefits to Australia will include (i) quantitative knowledge of the exposure to nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates and (ii) a breakthrough in the scientific understanding of the specific particle properties, which have impacts on health effects. The ultimate economic benefit will be improved urban design to lower, in pa ....The Effects of Nano and Ultrafine Particles from Traffic Emissions on Children's Health. The socio-economic benefits to Australia will include (i) quantitative knowledge of the exposure to nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates and (ii) a breakthrough in the scientific understanding of the specific particle properties, which have impacts on health effects. The ultimate economic benefit will be improved urban design to lower, in particular, children's exposure to ultrafine particles, thus reducing life long impacts, health care cost and productivity losses. The research will also place Australia at the forefront of international progress towards better methods for achieving environmental and public health sustainability.Read moreRead less
Establishing Guidelines for Coronial Best Practice Use of Internal Autopsy. Last year in Queensland 2700 Coronial internal autopsies were conducted at a cost of $5.3 million. In addition to the economic cost, other relevant concerns include few qualified personnel, public health risks, and cultural and religious sensitivities associated with internal autopsy. Anecdotal evidence suggests that for a number of these deaths, the internal autopsy was not necessary to establish cause or circumstance ....Establishing Guidelines for Coronial Best Practice Use of Internal Autopsy. Last year in Queensland 2700 Coronial internal autopsies were conducted at a cost of $5.3 million. In addition to the economic cost, other relevant concerns include few qualified personnel, public health risks, and cultural and religious sensitivities associated with internal autopsy. Anecdotal evidence suggests that for a number of these deaths, the internal autopsy was not necessary to establish cause or circumstance of death. The purpose of this research is to create guidelines to enable coroners to weight all sources of evidence before ordering internal autopsies The purpose is to decrease the number (and associated costs, risks and distress to families) of unnecessary internal autopsies being performed without compromising the finding as to cause and circumstance of death.Read moreRead less
Emergency Health Services: Demand and service delivery models. Congestion of emergency health services is causing considerable community concern regarding Australia's capacity to manage daily health emergencies and to respond to major incidents and disasters. The service models developed in this project will provide the basis for policy and service initiatives which will address the growing demand for emergency health services more efficiently and effectively and thus meet community expectations ....Emergency Health Services: Demand and service delivery models. Congestion of emergency health services is causing considerable community concern regarding Australia's capacity to manage daily health emergencies and to respond to major incidents and disasters. The service models developed in this project will provide the basis for policy and service initiatives which will address the growing demand for emergency health services more efficiently and effectively and thus meet community expectations. Improved services will result in improved community health and wellbeing. This project will also develop the research capacity of Australia through training of key individuals who will lead future research and development of emergency health services in Australia.Read moreRead less