Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100001
Funder
Australian Research Council
Funding Amount
$345,475.00
Summary
Pushing the limits of fluorescence microscopy with adaptive optics. This project aims to establish an adaptive optics, super-resolution optical microscopy facility to image cellular events with the highest possible spatial resolution, in a whole cell or tissue context. Sophisticated computer-controlled deformable mirrors will be used to correct the way light is distorted as it passes through specimens, thereby overcoming aberrations found in thick and complex samples. This adaptive optics system ....Pushing the limits of fluorescence microscopy with adaptive optics. This project aims to establish an adaptive optics, super-resolution optical microscopy facility to image cellular events with the highest possible spatial resolution, in a whole cell or tissue context. Sophisticated computer-controlled deformable mirrors will be used to correct the way light is distorted as it passes through specimens, thereby overcoming aberrations found in thick and complex samples. This adaptive optics system will enable researchers to study complex behaviour of biological specimens, at the optical resolution limit in plant and animal tissues, leading to basic biology and biotechnology outcomes in biofuels, biomaterials and biomedicines.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100133
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Expansion and Upgrade of the Newcastle Plant Growth Facility. Expansion and upgrade of the Newcastle plant growth facility: The project will upgrade and expand the Newcastle plant growth facility to ensure a continuous supply of high quality plant material required for competitively-funded research programs. This outcome will be achieved by replacing plant growth cabinets that have passed their built-in 15 year redundancy by many years, and the addition of specialist cabinets for Arabidopsis res ....Expansion and Upgrade of the Newcastle Plant Growth Facility. Expansion and upgrade of the Newcastle plant growth facility: The project will upgrade and expand the Newcastle plant growth facility to ensure a continuous supply of high quality plant material required for competitively-funded research programs. This outcome will be achieved by replacing plant growth cabinets that have passed their built-in 15 year redundancy by many years, and the addition of specialist cabinets for Arabidopsis research housed in a renovated PC2 space. Together, the infrastructure additions will enhance the productivity and excellence of core areas of plant biology research in plant development and nutrient transport, which are both areas of research that will be critical to address issues of food security in the future.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100015
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need ....An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need for advanced mass spectrometry-based lipid analysis capabilities across mammalian, plant, parasite, and microalgae research disciplines, as well as enabling fundamental studies of lipid separation, chemistry and reactivity. The instrumentation would be applicable to a diverse range of projects including studies of the role of lipid metabolism in mammalian biochemistry and cell biology, plant biology and parasitology, and micro algae biofuel production.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100770
Funder
Australian Research Council
Funding Amount
$325,375.00
Summary
Lignin in ionic liquids: electrochemical approaches towards delignification and depolymerisation. Wood contains a wealth of biomaterials, such as cellulose which can be used to make biofuel and lignin which can be used to make pharmaceuticals. Separating out the cellulose is essential yet difficult, plus lignin must be broken up into smaller fragments; this project will look at using electrochemistry to achieve these processes more efficiently.
Elucidating the genetic basis of newly evolved metabolic functions in yeast. Elucidating the genetic basis of newly evolved metabolic functions in yeast. This project intends to research how complex metabolic pathways originate and evolve. This project will use cutting edge genome sequencing and molecular techniques to elucidate the heritable genetic basis of Baker’s yeast, which has been the selectively evolved to use xylose as a sole carbon source: something vital for second generation biofuel ....Elucidating the genetic basis of newly evolved metabolic functions in yeast. Elucidating the genetic basis of newly evolved metabolic functions in yeast. This project intends to research how complex metabolic pathways originate and evolve. This project will use cutting edge genome sequencing and molecular techniques to elucidate the heritable genetic basis of Baker’s yeast, which has been the selectively evolved to use xylose as a sole carbon source: something vital for second generation biofuel production that wild yeast cannot do. This project will combine detailed molecular characterisation of highly adapted yeast strains with a novel "molecular palaeontology" approach to trace the evolutionary process and identify functionally significant loci under selection. Detailed characterisation of this trait will accelerate the development of future yeast strains and test fundamental evolutionary theories.Read moreRead less
Phase stability of biomass fast pyrolysis bio-oil: behaviour and control. This project aims to carry out a systematic investigation into the phase behaviour and control of biomass fast pyrolysis into bio-oil and its derived fuels. The project addresses the major problem of fuel phase separation during processing and handling that cause significant operational challenges, for example pumping difficulties and line clogging, during storage, transport and applications of these fuels. The outcomes in ....Phase stability of biomass fast pyrolysis bio-oil: behaviour and control. This project aims to carry out a systematic investigation into the phase behaviour and control of biomass fast pyrolysis into bio-oil and its derived fuels. The project addresses the major problem of fuel phase separation during processing and handling that cause significant operational challenges, for example pumping difficulties and line clogging, during storage, transport and applications of these fuels. The outcomes include the discovery of fundamental knowledge on the phase structure, stability and behaviour of the products of biomass fast pyrolysis bio-oil and its derived fuels and the development of essential engineering tools for predicting and controlling phase behaviour and stability of these fuels.Read moreRead less
Molecular Resolution 3D Atlas of the Photosynthetic Machinery. The project aims to produce an atomic-resolution 3-D atlas of the photosynthetic machinery of single-cell green algae to guide the targeted engineering of high efficiency algae production cell lines and bio-inspired artificial solar fuel systems. Photosynthesis drives the first step of all algae production processes by capturing solar energy and converting it to chemical energy (for example sustainable fuels, food and high value prod ....Molecular Resolution 3D Atlas of the Photosynthetic Machinery. The project aims to produce an atomic-resolution 3-D atlas of the photosynthetic machinery of single-cell green algae to guide the targeted engineering of high efficiency algae production cell lines and bio-inspired artificial solar fuel systems. Photosynthesis drives the first step of all algae production processes by capturing solar energy and converting it to chemical energy (for example sustainable fuels, food and high value products), but excess light can cause photodamage. Microalgae have evolved intricate photo-protection mechanisms that can dissipate up to 90 per cent of the captured light energy. Fine-tuning the light harvesting complexes could considerably increase efficiency.Read moreRead less
Atomic scale information for the design of nanomaterials. This project aims to develop a new tool to measure the 3-D distribution of atoms within nanoparticles. For the rational design of nanoparticles, it is necessary to compare the atomic scale structure to the resulting performance. But this information is hard to access. This projects aims to develop new methods so that atom probe microscopy can be applied to experimentally measure the precise 3-D location and identity of the individual atom ....Atomic scale information for the design of nanomaterials. This project aims to develop a new tool to measure the 3-D distribution of atoms within nanoparticles. For the rational design of nanoparticles, it is necessary to compare the atomic scale structure to the resulting performance. But this information is hard to access. This projects aims to develop new methods so that atom probe microscopy can be applied to experimentally measure the precise 3-D location and identity of the individual atoms within nanoparticles, and apply them in the development of alloy catalyst nanoparticles that could make the sustainable production of liquid fuels from biomass commercially viable. These new tools would be useful across the wide range of engineering applications for which nanomaterials are currently being developed.Read moreRead less
In-situ catalytic upgrading of bio-oil using scrap tyre char. This project aims to develop advanced, cost-competitive catalysts based on scrap tyre char, an otherwise low-value by-product. These catalysts will be optimised for use in upgrading bio-oil derived from the pyrolysis of woody eucalyptus, an abundant biomass resource across Australia. The project is expected to promote the commercialisation of bio-oil production and enhance the valorisation of scrap tyre char. This is expected to reduc ....In-situ catalytic upgrading of bio-oil using scrap tyre char. This project aims to develop advanced, cost-competitive catalysts based on scrap tyre char, an otherwise low-value by-product. These catalysts will be optimised for use in upgrading bio-oil derived from the pyrolysis of woody eucalyptus, an abundant biomass resource across Australia. The project is expected to promote the commercialisation of bio-oil production and enhance the valorisation of scrap tyre char. This is expected to reduce the carbon footprint from Australian industry, and promote the recycling and reuse of waste scrap tyres.Read moreRead less
Yeast cell-cell communication of overcrowding and nutrient limitation: novel signalling systems and their impact on fermentation. The project will investigate known and novel signalling molecules that allow communication between yeast cells and impact on fermentation dynamics, specifically in a nutrient-depleted environment. The mechanisms by which these molecules exert their effect will be defined using a systems biology approach that integrates many analyses and data sets.