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Fluid mechanics and physiology of blockages in vascular systems. Vascular disease is a major health problem both in Australia and worldwide. In particular, cardiovascular disease is a major killer of adult Australians. Engineers and mathematicians working with biologists will gain a greater understanding of vascular diseases, a major health problem, including cardiovascular disease, which is one of the biggest killers worldwide, as well as tackling renal circulation problems, which are a signifi ....Fluid mechanics and physiology of blockages in vascular systems. Vascular disease is a major health problem both in Australia and worldwide. In particular, cardiovascular disease is a major killer of adult Australians. Engineers and mathematicians working with biologists will gain a greater understanding of vascular diseases, a major health problem, including cardiovascular disease, which is one of the biggest killers worldwide, as well as tackling renal circulation problems, which are a significant problem and may contribute to hypertension. Detailed measurement and prediction will be undertaken of the mechanical loading and response of cells to their microenvironment, an important first step to controlling pathological responses which lead to a variety of autoimmune problems.Read moreRead less
Engineering Imaging and Supercomputer Prediction of Biofluid Flows. The potential of the information gained from the lung imaging for improving the diagnosis and monitoring of adult respiratory diseases, such as emphysema, pulmonary fibrosis and asthma, is enormous. Abnormalities in the structure and function of the kidney circulation are likely key factors causing hypertension, so a detailed understanding of the kidney circulation is required before we can cure or prevent hypertension. The rese ....Engineering Imaging and Supercomputer Prediction of Biofluid Flows. The potential of the information gained from the lung imaging for improving the diagnosis and monitoring of adult respiratory diseases, such as emphysema, pulmonary fibrosis and asthma, is enormous. Abnormalities in the structure and function of the kidney circulation are likely key factors causing hypertension, so a detailed understanding of the kidney circulation is required before we can cure or prevent hypertension. The research underpinning cardiovascular and renal flows will assist in the understanding of hypertension, a major risk factor for cardiovascular disease, which accounts for approximately 40% of all deaths in Australia and particularly high for dialysis patients. Read moreRead less
Gene therapy for islet transplantation. Improved understanding of aetiology of type I diabetes. Development of islet transplantation as a clinical therapeutic for type I diabetes. Improved efficacy of islet transplantation. Improved health for subjects with type I diabetes. Decreased diabetic complications. Improved quality of life for subjects with type I diabetes. Reduced burden on health system for management of diabetic complications for subjects with type I diabetes
Development of improved technologies for high throughput screening of potential disease susceptibility genes. This research is aimed at developing more efficient strategies to identify genes involved in common, human disorders. We aim to develop cost-effective, high throughput approaches for DNA extraction and preparation, accurately determining DNA concentration and quality and for undertaking extensive polymorphism genotyping and analysis. The suitability of equipment, analysis packages and so ....Development of improved technologies for high throughput screening of potential disease susceptibility genes. This research is aimed at developing more efficient strategies to identify genes involved in common, human disorders. We aim to develop cost-effective, high throughput approaches for DNA extraction and preparation, accurately determining DNA concentration and quality and for undertaking extensive polymorphism genotyping and analysis. The suitability of equipment, analysis packages and software, will be assessed and better technologies and packages developed. The study involves collaboration between a research centre with considerable expertise in molecular genetics and Corbett Research, a leader in the field of molecular equipment production. The development of better gene screening technologies has both molecular and commercial significance.Read moreRead less
Cellular uptake of glutathione transferases and their development as cell transfection agents. The function and survival of all cells requires the importation of a vast array of biochemical agents. In order for this to occur, these agents must be transported across the cell membrane wall. We are investigating a novel delivery system involving the enzyme glutathione transferase (GST). By investigating how GSTs cross membranes, we will be able to develop a new technology for the delivery of bio ....Cellular uptake of glutathione transferases and their development as cell transfection agents. The function and survival of all cells requires the importation of a vast array of biochemical agents. In order for this to occur, these agents must be transported across the cell membrane wall. We are investigating a novel delivery system involving the enzyme glutathione transferase (GST). By investigating how GSTs cross membranes, we will be able to develop a new technology for the delivery of biologically active molecules into cells. This exciting new technique will have applications in research and in the delivery of therapeutic drugs for the treatment of a range of diseases. Read moreRead less
Advanced microelectronic transistor structures for novel biosensor technology. This international, interdisciplinary team aims to develop an electronic biosensor technology that will significantly advance biomedical research to combat human disease. This is likely to have a major social impact on the community, improve health outcomes and generate substantial economic potential for the pharmaceutical industry. The principal benefit of this research will be the fabrication of electronic devices b ....Advanced microelectronic transistor structures for novel biosensor technology. This international, interdisciplinary team aims to develop an electronic biosensor technology that will significantly advance biomedical research to combat human disease. This is likely to have a major social impact on the community, improve health outcomes and generate substantial economic potential for the pharmaceutical industry. The principal benefit of this research will be the fabrication of electronic devices based on advanced materials, significantly reducing the time, the biological material used and the complexity of assessing human cell function. In addition to improving health through novel biosensor techniques, this technology is expected to lead to the creation of commercially important intellectual property.Read moreRead less
Preventing mental health problems in children: a population-based cluster controlled trial. The National Mental Health Survey (2000) found 1 in 7 children have externalising (aggression) and internalising (anxiety, depression) problems. Early mental health problems beget later problems with high costs to society, including clinical, remedial education and criminal justice services. Hence, early prevention is vital for national well-being and productivity. The few preventive early childhood progr ....Preventing mental health problems in children: a population-based cluster controlled trial. The National Mental Health Survey (2000) found 1 in 7 children have externalising (aggression) and internalising (anxiety, depression) problems. Early mental health problems beget later problems with high costs to society, including clinical, remedial education and criminal justice services. Hence, early prevention is vital for national well-being and productivity. The few preventive early childhood programs to date are limited in effectiveness and not truly population-based. The proposed parenting / family support trial aims to overcome these obstacles, by comparing and costing two approaches that can be implemented within whole communities. The trial will help clarify optimal primary care to prevent mental health problems early in life.Read moreRead less
After the questions: outcomes of routine screening for domestic violence in NSW Health services. Recent research indicates that domestic violence is the leading contributor to death, disability and illness in women aged 15-44 in Australia and leads to health costs of $314 m annually (VicHealth 2004, Access Economics 2004). Routine screening is a low cost measure aimed at prevention and early intervention for domestic violence, which has been successfully introduced for women entering antenatal, ....After the questions: outcomes of routine screening for domestic violence in NSW Health services. Recent research indicates that domestic violence is the leading contributor to death, disability and illness in women aged 15-44 in Australia and leads to health costs of $314 m annually (VicHealth 2004, Access Economics 2004). Routine screening is a low cost measure aimed at prevention and early intervention for domestic violence, which has been successfully introduced for women entering antenatal, early childhood, mental health and drug and alcohol services operated by NSW Health. The research will be the first study of its size to consider the outcomes of routine screening for domestic violence in public health settings in the Australian context.Read moreRead less
Citizen engagement: Listening to citizens' views about Australia's health system and prevention. This project will yield new and important perspectives from citizens on preventive health and health promotion, which can be used to develop better targeted and more effective prevention and promotion policies and strategies. Citizens views will be investigated in relation to vexed issues such as: new approaches to financing and program delivery, reorienting the health insurance sector, reorienting ....Citizen engagement: Listening to citizens' views about Australia's health system and prevention. This project will yield new and important perspectives from citizens on preventive health and health promotion, which can be used to develop better targeted and more effective prevention and promotion policies and strategies. Citizens views will be investigated in relation to vexed issues such as: new approaches to financing and program delivery, reorienting the health insurance sector, reorienting the health system to focus more on prevention and health promotion, improving current approaches of consumer participation in prevention and chronic disease management, tackling broader issues in public policy trade-offs between health and non-health, diversifying workforce roles and involving health professionals in prevention and promotion.Read moreRead less
Changing the media diet - Investigating the power of the news media to prevent obesity. Australia has 3.7 million obese people - twice as many are overweight. Australian experts say this epidemic, which costs Australia $58 billion a year, requires novel solutions at individual and societal levels. The news media are powerful shapers of public and policymakers' understandings of health issues. This project investigates competing arguments in news media and reality TV and how these frames influenc ....Changing the media diet - Investigating the power of the news media to prevent obesity. Australia has 3.7 million obese people - twice as many are overweight. Australian experts say this epidemic, which costs Australia $58 billion a year, requires novel solutions at individual and societal levels. The news media are powerful shapers of public and policymakers' understandings of health issues. This project investigates competing arguments in news media and reality TV and how these frames influence consumer understandings to discover what role the media are playing in the obesity epidemic. The goal is to relate the findings to scientific evidence and design novel strategic communication interventions to promote health through individual and societal interventions.Read moreRead less