Salmonella in poultry: improving vaccine efficacy . The central aim of this project is to increase the antigenicity of aroA mutant Salmonella Typhimurium vaccines, in particular Bioproperties’ Vaxsafe® ST. Increased antigenicity will affect the gut microbiota and stimulate a stronger host immune response improving vaccine efficacy and the duration of protection against S. Typhimurium in poultry. This will ultimately reduce bacterial loads in the farm environment, mitigate downstream contaminatio ....Salmonella in poultry: improving vaccine efficacy . The central aim of this project is to increase the antigenicity of aroA mutant Salmonella Typhimurium vaccines, in particular Bioproperties’ Vaxsafe® ST. Increased antigenicity will affect the gut microbiota and stimulate a stronger host immune response improving vaccine efficacy and the duration of protection against S. Typhimurium in poultry. This will ultimately reduce bacterial loads in the farm environment, mitigate downstream contamination of the food supply chain, and reduce the number of human salmonellosis cases.Read moreRead less
Reducing the health & economic burden of Campylobacter using a live vaccine. The aim of the project is to develop a vaccine to reduce Campylobacter bacteria in chickens. Campylobacters cause disease in both poultry and humans. Poultry products are the most common source of human infections. By reducing Campylobacter in poultry, the transfer to humans will be reduced. The expected outcomes arising from this work will be a reduction of the economic burden of poultry losses, in an Australian indust ....Reducing the health & economic burden of Campylobacter using a live vaccine. The aim of the project is to develop a vaccine to reduce Campylobacter bacteria in chickens. Campylobacters cause disease in both poultry and humans. Poultry products are the most common source of human infections. By reducing Campylobacter in poultry, the transfer to humans will be reduced. The expected outcomes arising from this work will be a reduction of the economic burden of poultry losses, in an Australian industry valued at $2.8 billion/year, and an improvement in food safety, thus helping to reduce the burden of foodborne illness, estimated to be $1.2 billion dollars/year. This project is, therefore, poised to benefit the Australian economy, specifically primary producers and the general public, by targeted vaccination of poultry.Read moreRead less
Vaccination of poultry infected with multiple Salmonella serovars. Salmonella is a zoonotic, foodborne pathogen found on eggs and poultry meat. It is the second largest cause of human gastrointestinal disease, thus, reduction of Salmonella on poultry farms is paramount to public health. This project aims to evaluate the long-term efficacy of a commercial Salmonella Typhimurium vaccine against multiple serotypes, including the emerging Salmonella Enteritidis. This project will generate new knowle ....Vaccination of poultry infected with multiple Salmonella serovars. Salmonella is a zoonotic, foodborne pathogen found on eggs and poultry meat. It is the second largest cause of human gastrointestinal disease, thus, reduction of Salmonella on poultry farms is paramount to public health. This project aims to evaluate the long-term efficacy of a commercial Salmonella Typhimurium vaccine against multiple serotypes, including the emerging Salmonella Enteritidis. This project will generate new knowledge in avian immunology using an innovative approach to evaluate the host response to multi-serovar infection. Outcomes of this project will future proof the Australian poultry industry against exotic Salmonella serotypes benefitting the industry by significantly reducing risks of future outbreaks and economic loss.Read moreRead less