Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four ne ....Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four neuronal cell cultures established with gene-based selection criteria. These cultures will be characterised by gene expression, immunocytochemistry, radiolabelled neurotransmitter release, electrophysiology and Ca2+ imaging studies. This study will highlight the functional effects of gene selection procedures upon stem cell-derived neurons.Read moreRead less
Special Research Initiatives - Grant ID: SR0566602
Funder
Australian Research Council
Funding Amount
$87,933.00
Summary
Development of a collaborative online environment and workbench for the investigation of protein folding. The investigation of protein folding – one the most important unsolved biological problems, is generating large amounts of complex data. This proposal aims to develop a highly collaborative content management system and interactive data mining tools that will allow the open exchange and analysis of protein folding data. A chief goal of this proposal is, by creating a rich informatics envir ....Development of a collaborative online environment and workbench for the investigation of protein folding. The investigation of protein folding – one the most important unsolved biological problems, is generating large amounts of complex data. This proposal aims to develop a highly collaborative content management system and interactive data mining tools that will allow the open exchange and analysis of protein folding data. A chief goal of this proposal is, by creating a rich informatics environment, to foster the exchange of ideas and rapid dissemination of new data across the international array of groups working in parallel on various aspects of the folding problem.Read moreRead less
Characterization and optimisation of Myomatrix: A novel extracellular matrix hydrogel from muscle. This project would have several sources of benefit for the community. Foremost we will have produced a product that will have a strong commercial application in several fields including basic science and bioengineering. If its full potential were achieved, the development of this innovative new hydrogel would strengthen Australia's standing in the biotechnology field and also enrich specific applic ....Characterization and optimisation of Myomatrix: A novel extracellular matrix hydrogel from muscle. This project would have several sources of benefit for the community. Foremost we will have produced a product that will have a strong commercial application in several fields including basic science and bioengineering. If its full potential were achieved, the development of this innovative new hydrogel would strengthen Australia's standing in the biotechnology field and also enrich specific applications. The knowledge gained from the characterization of this product could also be of benefit to several areas including chemical engineering, tissue engineering, tissue repair, polymer chemistry and food manufacture. The expertise generated and the possibility of collaboration, both academic and with industry would also benefit the community. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100125
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Oxidative stress bioanalytical facility. The primary national benefit of this application is that it will provide a currently unavailable, state-of-the-art facility for Australian scientists to define precisely how changes in cellular redox state contribute to biological processes relevant to health and diseases. The facility will uniquely complement, and in many cases integrate with existing facilities in this area of research in Australia. It will act as a platform for major national and inter ....Oxidative stress bioanalytical facility. The primary national benefit of this application is that it will provide a currently unavailable, state-of-the-art facility for Australian scientists to define precisely how changes in cellular redox state contribute to biological processes relevant to health and diseases. The facility will uniquely complement, and in many cases integrate with existing facilities in this area of research in Australia. It will act as a platform for major national and international research collaborations, develop cutting-edge technology and unique local skills, and contribute to Australia maintaining a leading position in redox-related research in biology and medicine. In doing so, the facility will increase the likelihood of gaining future, value-adding funding.Read moreRead less
Special Research Initiatives - Grant ID: SR0567460
Funder
Australian Research Council
Funding Amount
$85,000.00
Summary
Development of a collaborative environment for high throughput biology discovery pipelines. Modern biological science involves the parallel high-throughput investigation of many hundreds of different experimental targets. Traditional approaches for recording, analysing, mining and cross comparing experimental data are inadequate for conducting high throughput experiments. This proposal aims to develop new algorithms in the high throughput arena that will revolutionize biological discovery.
The cost of a meal: life-history consequences of foraging mode in fur seals and sea lions. Australia's two fur seal species are currently experiencing population increases throughout their range as they recover from the over-exploitation of the commercial sealing era (18-19th centuries) whereas the Australian sea lion population is decreasing (or stable but low) throughout its range and is considered vulnerable. Understanding the mechanisms which determine foraging efficiency in fur seals and s ....The cost of a meal: life-history consequences of foraging mode in fur seals and sea lions. Australia's two fur seal species are currently experiencing population increases throughout their range as they recover from the over-exploitation of the commercial sealing era (18-19th centuries) whereas the Australian sea lion population is decreasing (or stable but low) throughout its range and is considered vulnerable. Understanding the mechanisms which determine foraging efficiency in fur seals and sea lions will have implications for the management of these species, which are likely to experience increasing interactions with fisheries activities. The results of this research will assist in the development of policies to ensure the environmentally sustainable use of marine resources. Read moreRead less
DNA Dynamics is Shear and Extensional Flows: Simulation and Single Molecule Experiments. The proposal seeks to establish a collaboration between Monash University and Stanford University in order to combine several recent experimental and theoretical advances that have been made by the individual groups in single molecule experimental techniques, extensional rheometry, and molecular rheology, to obtain new insights into the structure and dynamics of biopolymers. The central aim is to make a sign ....DNA Dynamics is Shear and Extensional Flows: Simulation and Single Molecule Experiments. The proposal seeks to establish a collaboration between Monash University and Stanford University in order to combine several recent experimental and theoretical advances that have been made by the individual groups in single molecule experimental techniques, extensional rheometry, and molecular rheology, to obtain new insights into the structure and dynamics of biopolymers. The central aim is to make a significant contribution towards bringing state-of-the-art techniques used for the characterization of polymeric systems to bear on the nature and origin of the elastic properties of biopolymers.Read moreRead less
Effects of global climate change on marine phytoplankton: interactions between UV radiation and elevated atmospheric carbon dioxide levels. Global climate change is one of the most significant ecological challenges for the 21st Century. Phytoplankton contribute over 45% of the planet's annual net primary production and form the basis of most aquatic food chains. Conversely, some phytoplankton are toxic and cause problems in marine and fresh waters. Climate change can potentially disrupt aquatic ....Effects of global climate change on marine phytoplankton: interactions between UV radiation and elevated atmospheric carbon dioxide levels. Global climate change is one of the most significant ecological challenges for the 21st Century. Phytoplankton contribute over 45% of the planet's annual net primary production and form the basis of most aquatic food chains. Conversely, some phytoplankton are toxic and cause problems in marine and fresh waters. Climate change can potentially disrupt aquatic foodchains by its impact on primary production by phytoplankton or stimulating growth of potentially toxic forms. Our project will investigate the combined impact of increasing carbon dioxide and ultraviolet light on phytoplankton and thereby help climate modellers assess the impact of climate change on aquatic ecosystems and particularly on the nation's and the world's fisheries.Read moreRead less
The flow properties of proteins and other biopolymers. The living cell is an extraordinary organization with a vast variety of biomacromolecules carrying out myriads of functions with great specificity and accuracy. The key issue in cell biology is to unravel the structures of biopolymers and the deep connection that exists between structure and function. This interdisciplinary research program combines recent advances in experimental and theoretical rheology, with advances in protein science, t ....The flow properties of proteins and other biopolymers. The living cell is an extraordinary organization with a vast variety of biomacromolecules carrying out myriads of functions with great specificity and accuracy. The key issue in cell biology is to unravel the structures of biopolymers and the deep connection that exists between structure and function. This interdisciplinary research program combines recent advances in experimental and theoretical rheology, with advances in protein science, to investigate the response of biopolymers to deformation. This approach will lead to insights into the problem of protein folding, the interaction of biopolymers with surfaces, and the physical basis for the mechanical properties of biopolymers.Read moreRead less
ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand add ....ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand addresses issues about methodology, modelling toolkits, and management and control. Practical applications are advanced via collaborative projects that address key issues in biology, environment, and socio-economics.Read moreRead less