Australian Laureate Fellowships - Grant ID: FL0992270
Funder
Australian Research Council
Funding Amount
$3,080,000.00
Summary
Nutritional Dynamics: from Genes to Individuals to Ecosystems. Understanding how ecosystems function from the perspective of nutritional interactions between individual organisms will contribute to an environmentally sustainable Australia, with particular benefits to rural communities in arid/semi-arid regions. Research on human and animal nutrition, obesity and ageing will provide essential knowledge for promoting and maintaining good health and designing novel treatments for metabolic disorder ....Nutritional Dynamics: from Genes to Individuals to Ecosystems. Understanding how ecosystems function from the perspective of nutritional interactions between individual organisms will contribute to an environmentally sustainable Australia, with particular benefits to rural communities in arid/semi-arid regions. Research on human and animal nutrition, obesity and ageing will provide essential knowledge for promoting and maintaining good health and designing novel treatments for metabolic disorders. New ways of controlling locusts and other pest insects will arise and contribute to safeguarding Australia. New diet optimisation technologies will help transform Australian food production industries. The project will foster creative, innovative science that spans molecular biology to ecosystem dynamics.Read moreRead less
Early life overfeeding - mechanisms for programming obesity and long-term immune dysfunction. Early life overfeeding can lead to obesity and related changes in adulthood. With this study we will discover how overfeeding can permanently alter an animal's development so that its body weight and immune functions are dysregulated. The outcomes will facilitate appropriate design of animal experiments considering the impact of neonatal programming. They will also contribute to more efficient feeding p ....Early life overfeeding - mechanisms for programming obesity and long-term immune dysfunction. Early life overfeeding can lead to obesity and related changes in adulthood. With this study we will discover how overfeeding can permanently alter an animal's development so that its body weight and immune functions are dysregulated. The outcomes will facilitate appropriate design of animal experiments considering the impact of neonatal programming. They will also contribute to more efficient feeding protocols for meat production in agriculture and identify targets for risk management and for preventing and ameliorating early life overfeeding effects in humans. This investigation therefore has clear benefits to the social, economic, and health aspects of obesity and to basic science and agriculture.Read moreRead less
Programming of appetite and bodyweight by the interaction of maternal diet and angiotensin during peri-natal life. The project describes a phenotype for appetite and body weight that can be altered by maternal dietary omega-3 PUFA (environmental factors), at a critical period during peri-natal life (developmental phase) and that the effect on body weight is opposite when endogenous angiotensin is increased (hormonal factor). The project aims to discover how these different factors interact to p ....Programming of appetite and bodyweight by the interaction of maternal diet and angiotensin during peri-natal life. The project describes a phenotype for appetite and body weight that can be altered by maternal dietary omega-3 PUFA (environmental factors), at a critical period during peri-natal life (developmental phase) and that the effect on body weight is opposite when endogenous angiotensin is increased (hormonal factor). The project aims to discover how these different factors interact to produce the phenotype by defining the critical period and systematically identifying genes that are expressed during this period. The effect of manipulating maternal dietary omega-3 PUFA and the role of angiotensin will then be examined. The project will discover how genetic, hormonal and environmental factors interact during the perinatal period of life to program food intake and body weight in adult life. Read moreRead less