Plasmon nanobiosensor for whole blood analysis. The new method will be able to detect specific disease markers or to identify subtle differences in protein content in complex dense analytes such as blood and other body fluids, of practical utility in diagnostic and clinical situations. It will also be relevant in other areas such as medical diagnostics of viral diseases, and for unsolved environmental monitoring problems such as the presence of specific microorganisms in industrial waste. Owing ....Plasmon nanobiosensor for whole blood analysis. The new method will be able to detect specific disease markers or to identify subtle differences in protein content in complex dense analytes such as blood and other body fluids, of practical utility in diagnostic and clinical situations. It will also be relevant in other areas such as medical diagnostics of viral diseases, and for unsolved environmental monitoring problems such as the presence of specific microorganisms in industrial waste. Owing to their design simplicity and low cost of components, the devices developed in this program will lend themselves well to the development of new commercial technologies for Australia.Read moreRead less
Special Research Initiatives - Grant ID: SR0354517
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Adaptive Optics for Australian Astronomy, Medicine, Industry, and Defence. Adaptive optics is a technique for correcting wavefront distortions in light beams to improve optical imaging performance. The Research Network for Adaptive Optics aims to draw together isolated Australian and New Zealand research groups working on adaptive optics applications in disparate areas to achieve a critical mass of researchers in this burgeoning field. Adaptive optics has wide application in areas as diverse as ....Adaptive Optics for Australian Astronomy, Medicine, Industry, and Defence. Adaptive optics is a technique for correcting wavefront distortions in light beams to improve optical imaging performance. The Research Network for Adaptive Optics aims to draw together isolated Australian and New Zealand research groups working on adaptive optics applications in disparate areas to achieve a critical mass of researchers in this burgeoning field. Adaptive optics has wide application in areas as diverse as astronomy, vision science, ophthalmology, microscopy, optical communications, laser radar, and laser beam shaping. The Research Network will coordinate and expand Australian involvement in these areas and inform industry, as have similar networks in the USA and Europe.Read moreRead less
Optically-driven micromachines and microtools. The use of optical forces to trap and manipulate microscopic particles has developed from a novelty into a widely used versatile research tool - optical tweezers. New advances, such as the application and optical measurement of optical torque, have been brought to the brink of practical application. We will apply these methods to the development and production of micromachines of unprecedently small size, and the development of new medical diagnosti ....Optically-driven micromachines and microtools. The use of optical forces to trap and manipulate microscopic particles has developed from a novelty into a widely used versatile research tool - optical tweezers. New advances, such as the application and optical measurement of optical torque, have been brought to the brink of practical application. We will apply these methods to the development and production of micromachines of unprecedently small size, and the development of new medical diagnostic techniques, and industrial and research tools.Read moreRead less
Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical ....Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical science, imaging and sensing. Important applications include the early detection of debilitating diseases and the advancement of understanding of cellular biology. This research will raise Australia's profile as a world leader in science and technology, building on our emerging presence in the biophysical sciences.Read moreRead less
Quantitative polarisation phase microscopy: A new tool for advances in structural analysis and biophotonics. Innovation in biomedical research is driven by technology in optical imaging. Optical imaging methods including polarisation microscopy are widely accepted and are at the forefront of biomedical scientific discoveries. This project undertakes fundamental and applied research innovatively combining polarisation imaging and quantitative phase imaging microscopy to uniquely quantify the phys ....Quantitative polarisation phase microscopy: A new tool for advances in structural analysis and biophotonics. Innovation in biomedical research is driven by technology in optical imaging. Optical imaging methods including polarisation microscopy are widely accepted and are at the forefront of biomedical scientific discoveries. This project undertakes fundamental and applied research innovatively combining polarisation imaging and quantitative phase imaging microscopy to uniquely quantify the physical thickness and morphology of birefringent specimens such as the cardiac muscle cell. This project, while of substantial intellectual merit in its own right, could also have the potential to lead to the detection of the mechanisms related to heart failure. Read moreRead less
Scaling-up microstructured fibres for terahertz radiation. Terahertz radiation is the last region of the electromagnetic spectrum to be fully utilised. Many applications have been identified but their practicality has been limited by a lack of low-loss flexible waveguides. The waveguides to be developed in this project will build on Australia's existing international lead and investments in photonics as well as extend the dynamic field of microstructured optical fibres, indentified as the 'futur ....Scaling-up microstructured fibres for terahertz radiation. Terahertz radiation is the last region of the electromagnetic spectrum to be fully utilised. Many applications have been identified but their practicality has been limited by a lack of low-loss flexible waveguides. The waveguides to be developed in this project will build on Australia's existing international lead and investments in photonics as well as extend the dynamic field of microstructured optical fibres, indentified as the 'future' of optical fibres. Low-loss flexible waveguides will enable imaging and spectroscopy applications that can reveal and object's internal structure and composition. This will have immediate applications in security, quality control, medical imaging and other safety or industrial applications.Read moreRead less
New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray s ....New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray scientists of tomorrow, whose expertise will allow Australia to capitalize on its investment in the Australian Synchrotron.Read moreRead less
A wavelength-versatile visible laser for ophthalmic instrumentation. Treatment of a wide range of retinal disorders can be enhanced by a range of treatment modalities using laser beams of different colours. The outcome of this project will be a new laser technology for ophthalmic applications which is unique in its versatility while reducing size and cost. This will allow our partner, Opto Global, to gain a unique market position for its ophthalmic products with flow-on benefits to the Austral ....A wavelength-versatile visible laser for ophthalmic instrumentation. Treatment of a wide range of retinal disorders can be enhanced by a range of treatment modalities using laser beams of different colours. The outcome of this project will be a new laser technology for ophthalmic applications which is unique in its versatility while reducing size and cost. This will allow our partner, Opto Global, to gain a unique market position for its ophthalmic products with flow-on benefits to the Australian economy and ultimately benefits to the community through improved clinical efficacy and patient outcomes. The frontier technology represented by these new laser devices is also applicable to other industries including medical aesthetics, colour projection and display, and defence systems.Read moreRead less
Optical supercontinuum generation from high pulse-energy optical sources. The aim of this project is to develop a broadband and high brightness optical fibre source based on optical supercontinuum generation (i.e. low-coherence optical signals with octave or more bandwidth). Unlike similar sources demonstrated recently which rely on expensive bulk femtosecond pump lasers, this source will be pumped by a large pulse-energy optical fibre laser and use stimulated Raman scattering to seed the contin ....Optical supercontinuum generation from high pulse-energy optical sources. The aim of this project is to develop a broadband and high brightness optical fibre source based on optical supercontinuum generation (i.e. low-coherence optical signals with octave or more bandwidth). Unlike similar sources demonstrated recently which rely on expensive bulk femtosecond pump lasers, this source will be pumped by a large pulse-energy optical fibre laser and use stimulated Raman scattering to seed the continuum generation. The primary outcome will be a compact low-cost all-fibre supercontinuum source with a wide range of applications in areas such as optical metrology, optical coherence tomography, and high resolution non-contact position and motion sensing.Read moreRead less
Optical Fibre Touch Sensor for Cochlear Implants. The touch sensor will be part of a cochlear implant, which is surgically implanted to provide a sense of hearing for people who are profoundly or severely deaf. Approximately 100,000 people worldwide have received cochlear implants so far. However, the delicate internal structures of the ear can easily be damaged when the implant is inserted. By helping surgeons to preserve the inner ear, this sensor will help to further improve the hearing abili ....Optical Fibre Touch Sensor for Cochlear Implants. The touch sensor will be part of a cochlear implant, which is surgically implanted to provide a sense of hearing for people who are profoundly or severely deaf. Approximately 100,000 people worldwide have received cochlear implants so far. However, the delicate internal structures of the ear can easily be damaged when the implant is inserted. By helping surgeons to preserve the inner ear, this sensor will help to further improve the hearing ability of future patients. The 'bionic ear' was invented in Australia and this project will help to ensure the continued success of Australia's world leading implant industry.Read moreRead less