Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision system ....ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision systems with applications in industry and national security. Other knowledge will develop novel diagnostic technologies, for application in health delivery.Read moreRead less
Hybrid Sensor-based Physiological Control of an Implantable Rotary Blood Pump. With over 11 million people needing heart transplants worldwide and only 3000 donor hearts, an effective alternative therapy is needed. The Ventracor Ltd. rotary blood pump is one possible approach whereby a fully implantable mechanical device assists the failing heart. The innovative steps in this research proposal will be a means to robustly and safely control the speed of the pump to meet the metabolic needs of the ....Hybrid Sensor-based Physiological Control of an Implantable Rotary Blood Pump. With over 11 million people needing heart transplants worldwide and only 3000 donor hearts, an effective alternative therapy is needed. The Ventracor Ltd. rotary blood pump is one possible approach whereby a fully implantable mechanical device assists the failing heart. The innovative steps in this research proposal will be a means to robustly and safely control the speed of the pump to meet the metabolic needs of the body. Apart from the obvious health benefits for patients, this will provide the company with a huge market advantage that will also help to bolster the Australian medical device industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347024
Funder
Australian Research Council
Funding Amount
$140,000.00
Summary
Research facility in micromanipulation. The aim of the program is to establish a unique joint facility between Monash and Deakin for micromanipulation research. The proposed facility will consist of complex/intelligent micromanipulation systems capable of motion accuracy of 0.01-0.1 micrometer (10-100 nm). This will be the only facility of its kind in Australia and will provide a key enabling technology in the research and development of advanced micromanipulation systems, robotic-assisted mic ....Research facility in micromanipulation. The aim of the program is to establish a unique joint facility between Monash and Deakin for micromanipulation research. The proposed facility will consist of complex/intelligent micromanipulation systems capable of motion accuracy of 0.01-0.1 micrometer (10-100 nm). This will be the only facility of its kind in Australia and will provide a key enabling technology in the research and development of advanced micromanipulation systems, robotic-assisted microsurgery, sensory-based and intelligent control of complex systems, micro assembly/manufacturing, telerobotics/telesurgery, kinematics and dynamics of micromanipulators, laser-based control, and biotechnology. The facility will support and enhance a number of high-quality, current and future research projects with recognised potential.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775692
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Micro/nano optomechatronics sensing, measurement, and control research facility. This project aims to establish a facility that enhances the capabilities for sensing, positioning, and manipulating of micro/nano scale objects and environment, and as such constitutes the building block for many frontier technologies such as nanotechnology, bio/nano medicine, microsurgery and neurosurgery, biotechnology, microbiology, microfluidics, and micro/nano manufacturing, all of which are still in their infa ....Micro/nano optomechatronics sensing, measurement, and control research facility. This project aims to establish a facility that enhances the capabilities for sensing, positioning, and manipulating of micro/nano scale objects and environment, and as such constitutes the building block for many frontier technologies such as nanotechnology, bio/nano medicine, microsurgery and neurosurgery, biotechnology, microbiology, microfluidics, and micro/nano manufacturing, all of which are still in their infancy and promise to be the challenging areas of research for the next two decades. The outcomes will strengthen Australia's position in world-class innovative scientific research. It also strengthens collaboration between major engineering institutions and medical experts for innovative research and training of researchers.Read moreRead less
Micromanipulation system. Many frontier areas such as micromanufacturing, microsurgery, biotechnology, and nanotechnology require high precision micromanipulation systems. This project aims to investigate fundamental issues in micromanipulation systems using an ARC-LIEF funded research facility, and establish methodologies for modelling and analysis, together with their experimental verification to evaluate the influence of various parameters in such systems. The findings will be utilised to e ....Micromanipulation system. Many frontier areas such as micromanufacturing, microsurgery, biotechnology, and nanotechnology require high precision micromanipulation systems. This project aims to investigate fundamental issues in micromanipulation systems using an ARC-LIEF funded research facility, and establish methodologies for modelling and analysis, together with their experimental verification to evaluate the influence of various parameters in such systems. The findings will be utilised to establish sensory-based control techniques to solve problems associated with predictability, control, and efficiency for future advancement of such novel systems. The outcomes will include acquiring new knowledge in micromanipulation systems for potential utilization of the innovative concepts in the frontier areas.Read moreRead less
Haptic exploration and manipulation of micro/nano scale environment. The proposed research is novel and innovative in character and it has potential benefits in many frontier areas utilising micro/nano manipulation systems. These include micromanufacturing and instrumentation, microbiology, microsurgery and nanotechnology. The outcomes of this project will add to the growth of world-class Australian engineering science, and consolidate Australia's position in innovative technologies and internat ....Haptic exploration and manipulation of micro/nano scale environment. The proposed research is novel and innovative in character and it has potential benefits in many frontier areas utilising micro/nano manipulation systems. These include micromanufacturing and instrumentation, microbiology, microsurgery and nanotechnology. The outcomes of this project will add to the growth of world-class Australian engineering science, and consolidate Australia's position in innovative technologies and international R&D. This highly challenging project will provide training for postdoctorate researchers, postgraduate and honours students. These researchers will gain expertise in many areas including micro/nano manipulation, sensing and control, system design and analysis, virtual reality and experimental techniques.Read moreRead less
New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray s ....New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray scientists of tomorrow, whose expertise will allow Australia to capitalize on its investment in the Australian Synchrotron.Read moreRead less
High-Fidelity Modelling for Robotic-Assisted Minimally Invasive Needle Insertion. This project will develop robotic-assisted needle insertion and greatly improve minimally invasive surgery. It will also enhance the establishment of intellectual property for Australian medicine and produce important benefits to the healthcare sector. The proposed symbiotic integration of the systems will advance modelling technologies, and further create new capabilities for a wide range of science and engineerin ....High-Fidelity Modelling for Robotic-Assisted Minimally Invasive Needle Insertion. This project will develop robotic-assisted needle insertion and greatly improve minimally invasive surgery. It will also enhance the establishment of intellectual property for Australian medicine and produce important benefits to the healthcare sector. The proposed symbiotic integration of the systems will advance modelling technologies, and further create new capabilities for a wide range of science and engineering applications. The established methodologies and systems will also provide great potential benefits in many other areas, including microbiology, life sciences and bio/nano-technology. The project's outcomes will further consolidate Australia's position in innovative technologies and international research and development.Read moreRead less
Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less