Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision system ....ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision systems with applications in industry and national security. Other knowledge will develop novel diagnostic technologies, for application in health delivery.Read moreRead less
Hybrid Sensor-based Physiological Control of an Implantable Rotary Blood Pump. With over 11 million people needing heart transplants worldwide and only 3000 donor hearts, an effective alternative therapy is needed. The Ventracor Ltd. rotary blood pump is one possible approach whereby a fully implantable mechanical device assists the failing heart. The innovative steps in this research proposal will be a means to robustly and safely control the speed of the pump to meet the metabolic needs of the ....Hybrid Sensor-based Physiological Control of an Implantable Rotary Blood Pump. With over 11 million people needing heart transplants worldwide and only 3000 donor hearts, an effective alternative therapy is needed. The Ventracor Ltd. rotary blood pump is one possible approach whereby a fully implantable mechanical device assists the failing heart. The innovative steps in this research proposal will be a means to robustly and safely control the speed of the pump to meet the metabolic needs of the body. Apart from the obvious health benefits for patients, this will provide the company with a huge market advantage that will also help to bolster the Australian medical device industry.Read moreRead less
Design of an electronic guideline-driven decision support framework for home and community telehealth settings. With rapid advancements in the use of telecare-based health support in several emerging clinical areas, integrating these services within a stable guideline-driven decision support framework will support evidence-best practice in this setting, as well as improving efficiencies in clinical work practice and error minimisation through automation. The result could have a profound socio-ec ....Design of an electronic guideline-driven decision support framework for home and community telehealth settings. With rapid advancements in the use of telecare-based health support in several emerging clinical areas, integrating these services within a stable guideline-driven decision support framework will support evidence-best practice in this setting, as well as improving efficiencies in clinical work practice and error minimisation through automation. The result could have a profound socio-economic impact on the community and a sizable impact on healthcare outcomes; notwithstanding the substantial contribution it has to advancing the knowledge of medical decision support systems, supporting the national technology focus on health technology interoperability, and raising the profile of Australia as the foremost leader in the telecare area. Read moreRead less
Special Research Initiatives - Grant ID: SR0354734
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving h ....The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving health care and reducing health care costs. To be successful, a device must include all relevant disciplines in the research, development and testing phases. This network will bring together these groups, promoting knowledge sharing and cross-disciplinary investigations that illuminate current device limitations and potential solutions.Read moreRead less
Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of profi ....Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of proficiency testing and continuing education vital for a vibrant, well regulated discipline. In addition, the project will contribute to our knowledge of the pathology assessed in the screening and diagnosis of cancers such as cervical, lung and bladder cancers.Read moreRead less
Cytorefractometry - a new technique for refractive index tomography of living cells. An ultrahigh-resolution bifocal optical coherence refractometry is proposed, and will result to micron-scale-resolution refractive index tomography of living cells, termed cytorefractometry. This technique represents an extension from bifocal optical coherence refractometry that has recently shown a remarkable promise for direct, several-frames-per-second, motion-artifact-free determination of refractive index ....Cytorefractometry - a new technique for refractive index tomography of living cells. An ultrahigh-resolution bifocal optical coherence refractometry is proposed, and will result to micron-scale-resolution refractive index tomography of living cells, termed cytorefractometry. This technique represents an extension from bifocal optical coherence refractometry that has recently shown a remarkable promise for direct, several-frames-per-second, motion-artifact-free determination of refractive index in turbid media, including biological tissue in vivo. We propose to apply our novel technique to study tissue calcification, a serious problem in cardiology, by making use of the refractive index contrast mechanism. Calcification of smooth muscle cells and aorta subdermal implant models will be studied aiming for prevention of calcification-associated pathologies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560716
Funder
Australian Research Council
Funding Amount
$864,610.00
Summary
A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The o ....A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The outcome will be a strategically important Australian T-ray facility that will provide immediate and transparent nationwide access. Historically, industry is transformed every time a new part of the electromagnetic spectrum becomes accessible - T-rays are the next frontier.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775649
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
An Integrated Multi-Node Microfluidics Facility. The establishment of the proposed facility will enhance Australia's position in microfluidics research, thus contributing to all National Priority areas, particularly the National Priority area 3 through advancement in breakthrough science and frontier technologies. In addition to researchers from participating institutions, the Facility will be made available to other Australian researchers from non-participating organisations at minimum cost. Th ....An Integrated Multi-Node Microfluidics Facility. The establishment of the proposed facility will enhance Australia's position in microfluidics research, thus contributing to all National Priority areas, particularly the National Priority area 3 through advancement in breakthrough science and frontier technologies. In addition to researchers from participating institutions, the Facility will be made available to other Australian researchers from non-participating organisations at minimum cost. The socio-economic potentials of the research carried out using the proposed facility are significant and include: R&D development, small scale high technology manufacture, exports, and improved methods of biochemical processing and medical diagnostics.Read moreRead less