Biophysics-informed deep learning framework for magnetic resonance imaging. This project aims to bring about a paradigm shift from the conventional non-quantitative magnetic resonance imaging to ultra-fast, quantitative, and artefact free imaging. This project integrates biophysics and artificial intelligence, and it is expected to bring new knowledge in both fields. The expected outcomes of this project include next generation magnetic resonance imaging methods with a fundamental shift in the ....Biophysics-informed deep learning framework for magnetic resonance imaging. This project aims to bring about a paradigm shift from the conventional non-quantitative magnetic resonance imaging to ultra-fast, quantitative, and artefact free imaging. This project integrates biophysics and artificial intelligence, and it is expected to bring new knowledge in both fields. The expected outcomes of this project include next generation magnetic resonance imaging methods with a fundamental shift in the approach to image artefacts and image quantification. This project is expected to advance both single subject and population level biomedical imaging with greater accuracy and cost-effectiveness. This project also promotes explainable and generalisable artificial intelligence in medical imaging.Read moreRead less
Bioinspired Flexible Haptic Memory Materials for Artificial Sensory Nerves. This project aims to develop next generation haptic memory materials for the applications of artificial sensory nerves, which can precisely detect, process and respond to mechanical stimuli. The project expects to achieve this aim by mimicking the functions of biological haptic memory system and integrating highly sensitive tactile sensors and synaptic devices into artificial sensory nerves. The anticipated outcomes wil ....Bioinspired Flexible Haptic Memory Materials for Artificial Sensory Nerves. This project aims to develop next generation haptic memory materials for the applications of artificial sensory nerves, which can precisely detect, process and respond to mechanical stimuli. The project expects to achieve this aim by mimicking the functions of biological haptic memory system and integrating highly sensitive tactile sensors and synaptic devices into artificial sensory nerves. The anticipated outcomes will be new electronic materials for a wide range of end uses in next-generation flexible sensor technologies including healthcare monitoring devices, intelligent soft robotic systems and neural prosthetics.Read moreRead less
A novel precision-engineered microfluidic chip for wear particle research. This project aims to develop 1- novel protocols to generate clinically-relevant wear particles from spinal implants in-vitro and 2- a technological framework for the fabrication of a novel microfluidic 3D spinal implant-on-a-chip with tailored mechanical, material and biological properties. This will provide a cost-effective tool, currently unavailable, that allows investigation into the impact of wear particles on health ....A novel precision-engineered microfluidic chip for wear particle research. This project aims to develop 1- novel protocols to generate clinically-relevant wear particles from spinal implants in-vitro and 2- a technological framework for the fabrication of a novel microfluidic 3D spinal implant-on-a-chip with tailored mechanical, material and biological properties. This will provide a cost-effective tool, currently unavailable, that allows investigation into the impact of wear particles on healthy spinal disc cells. We expect our technological framework to become an invaluable tool for biomedical engineers, biologists, and bio-engineers to work together and generate clinically relevant in-vitro data that supports optimisation for spinal implant design, fabrication, and safety. Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100035
Funder
Australian Research Council
Funding Amount
$4,743,710.00
Summary
ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to devel ....ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to develop ‘smart’ probes and ‘smart’ scanning, harnessing the digital revolution for better, cost effective diagnostic imaging and improved health outcomes.Read moreRead less
Breakthrough technologies in implantable bionics. This project aims to introduce revolutionary changes in implantable bionics via miniaturisation, automation and improved reliability and generating new knowledge by leveraging recent advances in laser processes. Expected outcomes include innovative hybrid thin-film/thick-film electrode arrays with more channels and charge-carrying capacity for neuromodulation; novel glass interfaces that facilitate deeply-miniaturised hermetic packages; and failu ....Breakthrough technologies in implantable bionics. This project aims to introduce revolutionary changes in implantable bionics via miniaturisation, automation and improved reliability and generating new knowledge by leveraging recent advances in laser processes. Expected outcomes include innovative hybrid thin-film/thick-film electrode arrays with more channels and charge-carrying capacity for neuromodulation; novel glass interfaces that facilitate deeply-miniaturised hermetic packages; and failure analysis to ensure study aims result in new processes that are as or more reliable than the current state-of-the-art. This work will create new and novel manufacturing processes, and trains the next generation of innovators equipped with the tools to advance implantable bionics into the future.Read moreRead less
Seeing the light: high-power visible-light generation using silicate fibre. Unlike their near-infrared counterparts, visible-light-emitting lasers are inefficient and complicated, impacting their broader deployment in industry, medicine, and telecommunications. To address this, we will create a new class of laser and amplifier based on an entirely new doped silicate glass fibre that will display low background loss and resilience to photodegradation from high-power visible light. This will solve ....Seeing the light: high-power visible-light generation using silicate fibre. Unlike their near-infrared counterparts, visible-light-emitting lasers are inefficient and complicated, impacting their broader deployment in industry, medicine, and telecommunications. To address this, we will create a new class of laser and amplifier based on an entirely new doped silicate glass fibre that will display low background loss and resilience to photodegradation from high-power visible light. This will solve one of the last important problems in fibre laser research. The primary outcome will be a series of high-power continuous-wave, ultrashort-pulse, all-fibre lasers emitting at yellow and red wavelengths, with significant benefits for space, defence, manufacturing, and human health.Read moreRead less
Diamond Microneedles for Minimally Invasive Blood Collection. Blood sampling is a routine procedure for medical purposes to determine the physiological and biochemical status of patients. The aim of this project is to develop a reliable microneedle array for a blood collection procedures. Micro-scale needles for low-volume perforated blood samples are highly desirable due to its minimal invasiveness and painlessness. The miniaturization of sampling platforms driven by microneedles has the poten ....Diamond Microneedles for Minimally Invasive Blood Collection. Blood sampling is a routine procedure for medical purposes to determine the physiological and biochemical status of patients. The aim of this project is to develop a reliable microneedle array for a blood collection procedures. Micro-scale needles for low-volume perforated blood samples are highly desirable due to its minimal invasiveness and painlessness. The miniaturization of sampling platforms driven by microneedles has the potential to shift disease diagnosis and monitoring closer to the point of care. Expected outcomes include the development of synthetic diamond-based microneedles for the potential to greatly benefit society through improved and affordable healthcare and the development of new high-tech industries.Read moreRead less
Characterization, modelling and control for robotic thermal ablation. This project aims to study the fundamental issues in robotic-assisted minimally invasive thermal ablation, an important therapy for patients with cancer. It aims to establish advanced characterisation and modelling methodologies for thermomechanical behaviours of soft tissues, together with automatic planning and precise manipulation control techniques for robotic thermal ablation therapies. The project will establish new know ....Characterization, modelling and control for robotic thermal ablation. This project aims to study the fundamental issues in robotic-assisted minimally invasive thermal ablation, an important therapy for patients with cancer. It aims to establish advanced characterisation and modelling methodologies for thermomechanical behaviours of soft tissues, together with automatic planning and precise manipulation control techniques for robotic thermal ablation therapies. The project will establish new knowledge and instrumentation for robotic-assisted thermal ablation and minimally invasive surgery. The outcomes of this project will produce important benefits to medicine, healthcare and medical technology industry, and further consolidate Australia’s position in innovative technologies and research and development of advanced healthcare systems and instruments.Read moreRead less
Next generation photonic waveguide sensors enabled by machine learning. This project aims to establish the next frontier in photonic waveguide sensing, by using machine learning to shift the complexity out of conventional photonic-waveguide/optical-fibre sensors and into smart detection algorithms. The complexity and instability of multimode photonic waveguides, traditionally a hinderance to sensing, will be advantageously employed to train deep learning models for sensing. Expected outcomes inc ....Next generation photonic waveguide sensors enabled by machine learning. This project aims to establish the next frontier in photonic waveguide sensing, by using machine learning to shift the complexity out of conventional photonic-waveguide/optical-fibre sensors and into smart detection algorithms. The complexity and instability of multimode photonic waveguides, traditionally a hinderance to sensing, will be advantageously employed to train deep learning models for sensing. Expected outcomes include the creation of intelligent photonic sensors that can, in principle, measure any environmental parameter using any optical waveguide material. It will create new critically needed measurement capabilities for challenging harsh environments, such as extreme temperature and in-vivo biochemical sensing.Read moreRead less
Laser emission at the limit of glass transparency using nanocrystal doping . We will create a new composite glass providing strong fluorescence which fully exploits the high transmission of glass in the mid-infrared. When combined with emerging rare earth ion transitions and precise excitation processes, this project will help solve an important problem in optics; that the overall efficiency and power produced from deep mid-infrared light sources is not sufficient for all industries. The primary ....Laser emission at the limit of glass transparency using nanocrystal doping . We will create a new composite glass providing strong fluorescence which fully exploits the high transmission of glass in the mid-infrared. When combined with emerging rare earth ion transitions and precise excitation processes, this project will help solve an important problem in optics; that the overall efficiency and power produced from deep mid-infrared light sources is not sufficient for all industries. The primary outcome will be a series of robust fibre-based gain modules suitable for high power and very short optical pulses in the mid-infrared. These light sources will beneficially impact medicine, defence, sensing and manufacturing providing excellent opportunities for increasing Australian productivity and global competitiveness. Read moreRead less