Integrating dynamic and optimization models for efficient pipeline system operations in an evolving water and energy market. Developing an integrated dynamical and optimisation model for a piped water distribution system will advance Australia's capacity to deploy the most recent optimisation approaches to achieve the high level of efficiency required in the delivery of water to dryland regions. The outcomes of this project will be readily transferable to other regions and indeed other water d ....Integrating dynamic and optimization models for efficient pipeline system operations in an evolving water and energy market. Developing an integrated dynamical and optimisation model for a piped water distribution system will advance Australia's capacity to deploy the most recent optimisation approaches to achieve the high level of efficiency required in the delivery of water to dryland regions. The outcomes of this project will be readily transferable to other regions and indeed other water distribution systems. This will provide capability in securing Australia's water supplies and delivery systems. There may also be associated benefits to other pipeline operators in the oil and gas industries.Read moreRead less
Modelling patient flows through hospitals: optimizing effective use of resources. Hospitals are complex, dynamic systems confronted by increased demand in the face of shrinking real capacity. Managing such systems is currently undertaken with sub-optimal analytical support, particularly when demand and capacity are changing and resources must be manipulated to respond to such changes. In this project, the investigators will apply a mathematical modelling approach to the analysis of hospital pati ....Modelling patient flows through hospitals: optimizing effective use of resources. Hospitals are complex, dynamic systems confronted by increased demand in the face of shrinking real capacity. Managing such systems is currently undertaken with sub-optimal analytical support, particularly when demand and capacity are changing and resources must be manipulated to respond to such changes. In this project, the investigators will apply a mathematical modelling approach to the analysis of hospital patient flows. Furthermore, they will employ statistical process control methodologies to the problem of recognising and responding to changes in the flows, so that performance objectives are met. In doing this, they will give health service managers and clinicians a significant advantage in deciding how best to manage a constrained resource to maximize access, throughput and patient outcomes.Read moreRead less
Expenditure needs and drawdown of retirement savings during later life: how important are demographic factors and financial resources? Projections of expenditure patterns in retirement which allow for population heterogeneity will provide individuals with a better appreciation of their income needs and their savings requirements for a comfortable retirement. It will also enable financial institutions to develop products which better target retirees' needs over the course of retirement, and in ad ....Expenditure needs and drawdown of retirement savings during later life: how important are demographic factors and financial resources? Projections of expenditure patterns in retirement which allow for population heterogeneity will provide individuals with a better appreciation of their income needs and their savings requirements for a comfortable retirement. It will also enable financial institutions to develop products which better target retirees' needs over the course of retirement, and in addition it will enable improved assessment of aspects of Government income support policy. Specifically, understanding the complex interactions between private and public pensions, and concession card receipt upon expenditure behaviour, will enable more accurate costings of the public support of elderly families as Australia's population ages. Read moreRead less
Three dimensional computational models of geological basin and hinterland evolution incorporating lithospheric mantle and surface processes. Petroleum exploration in deepwater areas offshore Australia is becoming increasingly important as more accessible, shallow water oil reserves near exhaustion. Geological simulation is an important tool for understanding deep water basins where geophysical imaging techniques are less effective. This project will develop 3D computational models relevant to un ....Three dimensional computational models of geological basin and hinterland evolution incorporating lithospheric mantle and surface processes. Petroleum exploration in deepwater areas offshore Australia is becoming increasingly important as more accessible, shallow water oil reserves near exhaustion. Geological simulation is an important tool for understanding deep water basins where geophysical imaging techniques are less effective. This project will develop 3D computational models relevant to understanding the development and evolution of geological basins and the sediments that fill them. The models will be integrated with available offshore data for potentially prospective Australian basins in the Northwest Shelf and the Southern Australian margin.Read moreRead less
Patient-specific computational tools for evaluating functional performance of total knee replacements in vivo. Knee replacement surgery is the established treatment for end-stage osteoarthritis. This proposal addresses one of the most fundamental questions related to knee replacement surgery: Why do total knee replacements fail? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the functional performance and longevity o ....Patient-specific computational tools for evaluating functional performance of total knee replacements in vivo. Knee replacement surgery is the established treatment for end-stage osteoarthritis. This proposal addresses one of the most fundamental questions related to knee replacement surgery: Why do total knee replacements fail? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the functional performance and longevity of current knee implant designs. Realistic computer simulations of human movement also can play a pivotal role in healthcare through patient rehabilitation; in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of video games and animated films.Read moreRead less
Models for Australian Electricity Derivatives. Electricity derivatives, such as electricity futures and options are used to manage the risk associated with volatility in prices of electricity. This project aims to develop models for pricing electricity derivatives specifically suited for Australia. Because of the non-storable nature of electricity the standard option pricing principle of "no-arbitrage" does not apply to electricity options, such as caps and floors, but applies to options on elec ....Models for Australian Electricity Derivatives. Electricity derivatives, such as electricity futures and options are used to manage the risk associated with volatility in prices of electricity. This project aims to develop models for pricing electricity derivatives specifically suited for Australia. Because of the non-storable nature of electricity the standard option pricing principle of "no-arbitrage" does not apply to electricity options, such as caps and floors, but applies to options on electricity futures. Therefore a specific model is needed that takes into account the pricing principle of "no-arbitrage" and combines it with other factors that drive electricity prices. The novel element in this proposal is incorporation of the weather forecasts into the models for electricity options. As a result of this study appropriate models for electricity derivatives for various geographical regions in Australia will be developed.Read moreRead less
Using global optimization technique to determine the most efficient use of building/floor space to accommodate a given office design. The commercial property market is one of the largest business markets, both in Australia and globally. Businesses of all kinds use commercial office space, which represents many billions of investment dollars. A better understanding of what constitutes efficient and effective office space would produce enormous commercial benefits for this country. Historically, ....Using global optimization technique to determine the most efficient use of building/floor space to accommodate a given office design. The commercial property market is one of the largest business markets, both in Australia and globally. Businesses of all kinds use commercial office space, which represents many billions of investment dollars. A better understanding of what constitutes efficient and effective office space would produce enormous commercial benefits for this country. Historically, very little (if any) consideration has been given to the efficiency of office space design. The measurement of efficiency has now become an essential component of 'site selection'. To date, the application of optimization methodologies have not been applied to the architectural industry, making the development of tools to address this problem a significant and innovative move.Read moreRead less
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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Censored Regression Techniques for Credit Scoring. This project will apply censored regression techniques to a loans database from the industry partner, the ANZ bank. We will accurately estimate the actual time to loan repayment, rather than simply the risk of default. In a novel approach for credit scoring we will build a model using current, right-censored, rather than historic data, incorporating loans that are not yet repaid but are underway and clearly have a length of loan longer than obse ....Censored Regression Techniques for Credit Scoring. This project will apply censored regression techniques to a loans database from the industry partner, the ANZ bank. We will accurately estimate the actual time to loan repayment, rather than simply the risk of default. In a novel approach for credit scoring we will build a model using current, right-censored, rather than historic data, incorporating loans that are not yet repaid but are underway and clearly have a length of loan longer than observed. This approach has the immense advantage of being able to reflect contemporary borrowing patterns in the model, rather than relying on historic trends.
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