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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100026
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
VetCompass: Big Data and Real-time Surveillance for Veterinary Science. VetCompass: big data and real-time surveillance for veterinary science:
The VetCompass data service intends to collect real-time records from veterinary clinics and aggregate them for researchers to interrogate. It aims to provide Australian researchers with sustainable and cost-effective access to authoritative data from hundreds of practitioners in Australia and the United Kingdom. These data will be essential for researc ....VetCompass: Big Data and Real-time Surveillance for Veterinary Science. VetCompass: big data and real-time surveillance for veterinary science:
The VetCompass data service intends to collect real-time records from veterinary clinics and aggregate them for researchers to interrogate. It aims to provide Australian researchers with sustainable and cost-effective access to authoritative data from hundreds of practitioners in Australia and the United Kingdom. These data will be essential for research on disease distribution and determinants, and surveillance and diagnostics that underpin evidence-based practice. The expected outcomes include identification of the most prevalent disorders and their causes and optimal treatments. The data may also revolutionise clinical auditing in Australia, help the veterinary profession to rank research priorities, and inform companion animal and equine curricula in our universities.Read moreRead less
New targets for antiviral therapies. The ability of dangerous viruses to cause lethal disease depends on their capacity to evade the immune system of infected hosts. This project will uncover at the molecular level the strategies used by viruses to disable immune responses; this will identify new ways to treat incurable diseases, by disabling the virus' defences against the immune system.
The importance of DNA methylation in response to environmental changes. This project aims to investigate the importance of DNA methylation, a process whereby gene expression can be altered without changes in the DNA code, in regulating our responses to environmental challenges. It plans to do so using well-validated models of adult exposure to high fat diet or psychological stress in mice and tissue-specific (liver and brain) deletion of the major methylation enzymes. It aims to compare function ....The importance of DNA methylation in response to environmental changes. This project aims to investigate the importance of DNA methylation, a process whereby gene expression can be altered without changes in the DNA code, in regulating our responses to environmental challenges. It plans to do so using well-validated models of adult exposure to high fat diet or psychological stress in mice and tissue-specific (liver and brain) deletion of the major methylation enzymes. It aims to compare functional, gene expression and methylation status after such challenges in intact and methylase deleted animals to determine how vital this process really is. This work has major implications for our understanding of epigenetics, and the ways in which genes interact with the environment especially in times of change.Read moreRead less
Safeguarding honeybees: understanding host-parasite interactions at the level of proteins. Parasites are responsible for dramatic declines of honeybee populations resulting in a loss of pollination services and posing a threat to food production and ecosystem stability. This project will study the honeybee immune system and its interactions with bee parasites on the molecular scale, which will be important to guide future bee breeding.
Male to female sperm signalling – a new role for sperm in reproduction? Male seminal fluid is commonly thought simply to provide sperm for conception. This project aims to investigate a lesser known action of sperm: modifying the female immune response to increase the chances of reproductive success. The project aims to define the molecular pathway through which sperm interact with female cells, particularly how B-defensins on sperm bind to Toll-like receptors to stimulate female immune toleranc ....Male to female sperm signalling – a new role for sperm in reproduction? Male seminal fluid is commonly thought simply to provide sperm for conception. This project aims to investigate a lesser known action of sperm: modifying the female immune response to increase the chances of reproductive success. The project aims to define the molecular pathway through which sperm interact with female cells, particularly how B-defensins on sperm bind to Toll-like receptors to stimulate female immune tolerance. The project plans to use embryo transfer and genetic mouse models to determine the physiological benefit of sperm signalling. Evidence that seminal fluid signalling operates in mammals to ensure optimal female reproductive investment would advance knowledge of the male contribution to the reproductive process.Read moreRead less
The molecular basis of sperm competition. This project aims to unravel the molecular basis of reproductive conflicts. Males compete for paternity and this continues after mating if females copulate and receive semen from multiple males. In ants and bees, molecules in males’ ejaculates recognise and kill rival males’ sperm. Reproductive proteins in leaf cutter ants’ seminal fluid may be the molecular agents of sperm competition. This project will investigate reproductive proteins and their functi ....The molecular basis of sperm competition. This project aims to unravel the molecular basis of reproductive conflicts. Males compete for paternity and this continues after mating if females copulate and receive semen from multiple males. In ants and bees, molecules in males’ ejaculates recognise and kill rival males’ sperm. Reproductive proteins in leaf cutter ants’ seminal fluid may be the molecular agents of sperm competition. This project will investigate reproductive proteins and their functioning and effects on reproductive success. This project will show how reproductive conflicts over paternity operate on the protein level and may lead to novel avenues for future pest control.Read moreRead less
Linking evolutionary and molecular biology to safeguard Australian honeybees. Honeybee populations are declining globally but their pollination services are of central importance for food production. This project will study honeybee proteins that influence both fertility and immunity and their effects in vivo. This knowledge is of interest for the bee breeding industry to avoid or combat bee declines in managed Australian bees.
Safeguarding Honeybees: Increasing parasite treatment effectiveness using nanotechnology. There is increasing concern about the exposure of honeybees to pesticides used to control both agricultural pests and diseases. Emerging reports indicate that these chemicals substantially harm bees and therefore contribute to the dramatic declines reported. A widespread bee pathogen, Nosema, will be used to directly quantify the effectiveness of commercially used pesticides on both parasite and honeybee vi ....Safeguarding Honeybees: Increasing parasite treatment effectiveness using nanotechnology. There is increasing concern about the exposure of honeybees to pesticides used to control both agricultural pests and diseases. Emerging reports indicate that these chemicals substantially harm bees and therefore contribute to the dramatic declines reported. A widespread bee pathogen, Nosema, will be used to directly quantify the effectiveness of commercially used pesticides on both parasite and honeybee viability. Furthermore, state-of-the-art nanotechnology will be used to develop benign treatments with enhanced effectiveness and minimal dosage/exposure to the bees. Outcomes of this project can have major impact on future parasite management in commercial honeybees.Read moreRead less
Evolutionary proteomics of social insects. This project aims to understand the molecular mechanisms that affect fertility in honeybees and leaf-cutting ants by identifying the function of proteins in male and female secretions related to insemination and sperm storage. The understanding of these general principles will have important applications for honeybee breeding.
Cellular and molecular mechanisms for gut homeostasis in mammals. Certain molecules are responsible for gut homeostasis. This project aims to develop new tools to manipulate the cellular and molecular pathways around these molecules, which should provide benefit for human and animal health. This project will test whether the basis of many health conditions is disrupted gut homeostasis, through changes in diet and our gut bacteria.