The discovery and validation of novel drug classes against parasites with the potential for major economic impacts. This project will develop a quality scientific and technological program in national priority areas, leading to a strong basic research, new concepts and the enhanced international collaborative links; strengthen links between basic and applied research, and academia and industry; develop excellence via pan-Australian collaborations, resulting in a more efficient use of resources i ....The discovery and validation of novel drug classes against parasites with the potential for major economic impacts. This project will develop a quality scientific and technological program in national priority areas, leading to a strong basic research, new concepts and the enhanced international collaborative links; strengthen links between basic and applied research, and academia and industry; develop excellence via pan-Australian collaborations, resulting in a more efficient use of resources in a national and international context; enhance the skills-base in biology, biotechnology and chemistry; increase global visibility with increased investment in Australian science; improve animal welfare and production via improved control of infectious diseases; producing commercial products with benefits to agricultural producers in regional & rural communities.Read moreRead less
Novel, Cost-Effective Methods for Measuring Methane Emissions from Grazing Livestock. Agriculture is second only to energy generation as a source of greenhouse gas emissions in Australia. Methane from cattle and sheep constitute 60% of these agricultural emissions. Their abatement is a win-win goal for the agricultural industry, reducing greenhouse emissions while increasing food efficiency. This project will develop a novel, cost- and-labour efficient method for on-farm measurements of the emis ....Novel, Cost-Effective Methods for Measuring Methane Emissions from Grazing Livestock. Agriculture is second only to energy generation as a source of greenhouse gas emissions in Australia. Methane from cattle and sheep constitute 60% of these agricultural emissions. Their abatement is a win-win goal for the agricultural industry, reducing greenhouse emissions while increasing food efficiency. This project will develop a novel, cost- and-labour efficient method for on-farm measurements of the emissions of methane from free-grazing cattle and sheep in their undisturbed environment. The method will be used to assess the dependence of methane emissions on factors such as diet and the efficacy of proposed methods for abatement of methane emissions, as well as providing improved data to the National Greenhouse Gas Inventory.Read moreRead less
Molecular approaches to solving current and emerging problems in the epidemiology and diagnosis of Marek's disease in Australia. Marek's disease (MD) is a ubiquitous viral disease of chickens that is currently controlled in meat chickens by blanket vaccination of all chickens. However, as has happened overseas, the efficacy of the HVT vaccine being used in Australia is breaking down resulting in subclinical and clinical losses due to MD. To assist industry deal with this situation we propose to ....Molecular approaches to solving current and emerging problems in the epidemiology and diagnosis of Marek's disease in Australia. Marek's disease (MD) is a ubiquitous viral disease of chickens that is currently controlled in meat chickens by blanket vaccination of all chickens. However, as has happened overseas, the efficacy of the HVT vaccine being used in Australia is breaking down resulting in subclinical and clinical losses due to MD. To assist industry deal with this situation we propose to develop novel molecular methods for the quantification of Marek's disease viruses (MDV) in the host and the environment, to use these methods to design effective early monitoring systems for MD in broilers that predict disease and performance outcomes, and to develop an epidemiological model that will predict the spread and severity of MD as failure of vaccinal protection progresses.Read moreRead less
Evolutionary models and bioinformatic analyses of genetic variation in pathogens. The benefits of this project are better preparedness for the ever-present threat of infectious disease spread and the stimulation of bioinformatic research in Australia. Epidemics such as the Influenza Pandemic of 1918, which killed over 20 million people, highlight the need to understand and track pathogens that can potentially cause such devastation. Along with the development of molecular technologies, it is imp ....Evolutionary models and bioinformatic analyses of genetic variation in pathogens. The benefits of this project are better preparedness for the ever-present threat of infectious disease spread and the stimulation of bioinformatic research in Australia. Epidemics such as the Influenza Pandemic of 1918, which killed over 20 million people, highlight the need to understand and track pathogens that can potentially cause such devastation. Along with the development of molecular technologies, it is important to maintain active creation of analytical methods that appropriately apply to growing databases. These include methods to understand genetic variation in pathogens. This project will help to keep Australia at the forefront of research in theoretical biology.Read moreRead less
The importance of phenotypic plasticity in maintaining and introducing variation. This research is a synthesis of behaviour, natural and sexual selection, physiology, and natural and breeding ecology-important interactions that are rarely considered simultaneously in biology. It will contribute to our understanding of life-history decisions, and a long-neglected source of the variation that is the raw material for adaptation and for economically-important breeding programs . These results will h ....The importance of phenotypic plasticity in maintaining and introducing variation. This research is a synthesis of behaviour, natural and sexual selection, physiology, and natural and breeding ecology-important interactions that are rarely considered simultaneously in biology. It will contribute to our understanding of life-history decisions, and a long-neglected source of the variation that is the raw material for adaptation and for economically-important breeding programs . These results will have far-reaching implications for economically-important improvements to medicine, conservation, and crop and livestock production. This work will strengthen Australia's strong research profile in evolutionary genetics, physiology and ecology.Read moreRead less
Nutrient generation from rural land and delivery to streams in the Sydney Drinking Water Catchments. The Sydney Catchment Authority must manage pollution arising from land within its catchments. There have been few local studies of nutrient losses from rural land, the major land use, and the understanding of some important processes involved in nutrient generation and delivery is weak. Therefore model predictions are uncertain. This project will quantify nutrient losses from key land uses, ev ....Nutrient generation from rural land and delivery to streams in the Sydney Drinking Water Catchments. The Sydney Catchment Authority must manage pollution arising from land within its catchments. There have been few local studies of nutrient losses from rural land, the major land use, and the understanding of some important processes involved in nutrient generation and delivery is weak. Therefore model predictions are uncertain. This project will quantify nutrient losses from key land uses, evaluate alternative loss pathways, and provide insight into the effects of scale, providing a foundation for improved modelling of nutrient sources and transport. The outcome will be the capacity to prioritise land uses and parts catchments for remedial action, whilst providing a modelling approach relevant to the SCA and other catchment managers.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992270
Funder
Australian Research Council
Funding Amount
$3,080,000.00
Summary
Nutritional Dynamics: from Genes to Individuals to Ecosystems. Understanding how ecosystems function from the perspective of nutritional interactions between individual organisms will contribute to an environmentally sustainable Australia, with particular benefits to rural communities in arid/semi-arid regions. Research on human and animal nutrition, obesity and ageing will provide essential knowledge for promoting and maintaining good health and designing novel treatments for metabolic disorder ....Nutritional Dynamics: from Genes to Individuals to Ecosystems. Understanding how ecosystems function from the perspective of nutritional interactions between individual organisms will contribute to an environmentally sustainable Australia, with particular benefits to rural communities in arid/semi-arid regions. Research on human and animal nutrition, obesity and ageing will provide essential knowledge for promoting and maintaining good health and designing novel treatments for metabolic disorders. New ways of controlling locusts and other pest insects will arise and contribute to safeguarding Australia. New diet optimisation technologies will help transform Australian food production industries. The project will foster creative, innovative science that spans molecular biology to ecosystem dynamics.Read moreRead less
The development of a two-colour flow cytometric assay for the detection of whole cell biosensors in environmental samples. Macquarie University and the University of Copenhagen have expertise in fluorescence detection and whole cell biosensors respectively. The project will take advantage of these skills and develop a sensitive assay for monitoring biosensor bacteria in soil. The technology will be significant as it will enable real time analysis of antibiotic production in situ through the de ....The development of a two-colour flow cytometric assay for the detection of whole cell biosensors in environmental samples. Macquarie University and the University of Copenhagen have expertise in fluorescence detection and whole cell biosensors respectively. The project will take advantage of these skills and develop a sensitive assay for monitoring biosensor bacteria in soil. The technology will be significant as it will enable real time analysis of antibiotic production in situ through the detection of GFP expression. This work will then be used to isolate new antibiotic produces and will be extended to research into the bioavailability of toxic compounds and stress. An existing collaboration between the two institutions will be extended enabling the transfer and application of biosensor technology to Australia.Read moreRead less
Measurement of paddock scale pasture biomass using synthetic aperture radar remote sensing. To maintain the long-term viability of livestock production, producers and land managers need access to regular, timely and accurate estimates of pasture biomass. Radar remote sensing has the capacity to consistently provide this information at the paddock, farm and catchment scale in a timely manner to assist in tactical and strategic decision making for sustainable pasture and livestock management. Econ ....Measurement of paddock scale pasture biomass using synthetic aperture radar remote sensing. To maintain the long-term viability of livestock production, producers and land managers need access to regular, timely and accurate estimates of pasture biomass. Radar remote sensing has the capacity to consistently provide this information at the paddock, farm and catchment scale in a timely manner to assist in tactical and strategic decision making for sustainable pasture and livestock management. Economic analyses undertaken at the farm level have revealed the potential to double farm profit by increasing the utilization of pasture grown. In addition to the socio-economic benefits, the environmental benefits of sustainable land management are paramount in light of the current drought in Australia and the global climate change.Read moreRead less
Avoiding Environmental Bankruptcy: the grazing impacts of red kangaroos and sheep. Overgrazing is one of the most serious environmental and economic problems in Australia. By mitigating overgrazing, our project has three major benefits. Firstly, quantification of the foraging requirements for free-ranging sheep and kangaroos will, for the first time, allow us to identify sustainable practices that prevent overgrazing and contribute to significant land recovery. Secondly, a new mechanistic model ....Avoiding Environmental Bankruptcy: the grazing impacts of red kangaroos and sheep. Overgrazing is one of the most serious environmental and economic problems in Australia. By mitigating overgrazing, our project has three major benefits. Firstly, quantification of the foraging requirements for free-ranging sheep and kangaroos will, for the first time, allow us to identify sustainable practices that prevent overgrazing and contribute to significant land recovery. Secondly, a new mechanistic model for predicting herbivore dynamics will allow us to evaluate potential impacts of climate change on future grazing pressures. Thirdly, our results will inform management plans to sustain Australia's arid rangelands as productive, bio-diverse environments, which currently provide economic returns in excess of $20 billion p.a.Read moreRead less