Sustaining Australia's sheep industry under climate change: modelling Australia's sheep flock response to climatic and economic constraints. This project aims to provide a quantitative assessment of the impact of climate change and economic conditions on the Australian sheep industry. This will be achieved by constructing a robust dynamic model of the Australian sheep flock capable of integrating biophysical and economic constraints across regional and national scales. Using historical and proje ....Sustaining Australia's sheep industry under climate change: modelling Australia's sheep flock response to climatic and economic constraints. This project aims to provide a quantitative assessment of the impact of climate change and economic conditions on the Australian sheep industry. This will be achieved by constructing a robust dynamic model of the Australian sheep flock capable of integrating biophysical and economic constraints across regional and national scales. Using historical and projected biophysical and economic inputs it will enhance the capacity of the Australian sheep industry for strategic planning in the face of projected climate change. This capacity is being actively sought by the peak sheep industry bodies in conjunction with our industry partner the Bureau of Rural Sciences.Read moreRead less
Conservation management of seed-eating birds in the tropical savannas. Biodiversity loss in the savannas indicates unsustainable management. This research will enhance our abilities to effectively manage Australia's tropical savannas, as well as contributing to several State and Territory, Commonwealth and international obligations to maintain biodiversity. Understanding the processes underlying current declines will also make the effects of future management or environment changes easier to pre ....Conservation management of seed-eating birds in the tropical savannas. Biodiversity loss in the savannas indicates unsustainable management. This research will enhance our abilities to effectively manage Australia's tropical savannas, as well as contributing to several State and Territory, Commonwealth and international obligations to maintain biodiversity. Understanding the processes underlying current declines will also make the effects of future management or environment changes easier to predict. Retaining threatened species can benefit remote and regional communities through tourism, and also through the extra employment required to implement the management prescriptions that will be developed from this research.Read moreRead less
Molecular Interactions of Chemical Agents with Ion-Channel Proteins. With a minimal number of functional units (proteins) viruses are able to replicate. All of these proteins are possible antiviral targets. In this project we wil1 focus on a short protein called Vpu found in membranes of the HIV-1 virus and aim to analyse the interaction of potential pore blocking compounds. It is essential to know exactly where they sit and how the overall structure of Vpu is affected. For this enterprise we wi ....Molecular Interactions of Chemical Agents with Ion-Channel Proteins. With a minimal number of functional units (proteins) viruses are able to replicate. All of these proteins are possible antiviral targets. In this project we wil1 focus on a short protein called Vpu found in membranes of the HIV-1 virus and aim to analyse the interaction of potential pore blocking compounds. It is essential to know exactly where they sit and how the overall structure of Vpu is affected. For this enterprise we will use nuclear magnetic resonance (NMR) spectroscopy. This information will serve as a springboard for future investigations of virus membrane proteins.
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Nutrient generation from rural land and delivery to streams in the Sydney Drinking Water Catchments. The Sydney Catchment Authority must manage pollution arising from land within its catchments. There have been few local studies of nutrient losses from rural land, the major land use, and the understanding of some important processes involved in nutrient generation and delivery is weak. Therefore model predictions are uncertain. This project will quantify nutrient losses from key land uses, ev ....Nutrient generation from rural land and delivery to streams in the Sydney Drinking Water Catchments. The Sydney Catchment Authority must manage pollution arising from land within its catchments. There have been few local studies of nutrient losses from rural land, the major land use, and the understanding of some important processes involved in nutrient generation and delivery is weak. Therefore model predictions are uncertain. This project will quantify nutrient losses from key land uses, evaluate alternative loss pathways, and provide insight into the effects of scale, providing a foundation for improved modelling of nutrient sources and transport. The outcome will be the capacity to prioritise land uses and parts catchments for remedial action, whilst providing a modelling approach relevant to the SCA and other catchment managers.Read moreRead less
Synthetic compounds to specifically activate or inhibit ryanodine receptor calcium ion channels. The aim of the project is develop synthetic compounds that specifically and reversibly activate or inhibit ryanodine receptor calcium release channels, and will thus increase or reduce the force developed by skeletal muscle and the heart. The compounds will be useful in biomedical and veterinary sciences and in the livestock industry. Some of the compounds that are not effective on mammalian ryan ....Synthetic compounds to specifically activate or inhibit ryanodine receptor calcium ion channels. The aim of the project is develop synthetic compounds that specifically and reversibly activate or inhibit ryanodine receptor calcium release channels, and will thus increase or reduce the force developed by skeletal muscle and the heart. The compounds will be useful in biomedical and veterinary sciences and in the livestock industry. Some of the compounds that are not effective on mammalian ryandine receptor isoforms might interact with insect channels and provide a template for a new class of insecticides. The compounds will be based on naturally occurring peptides which specifically and reversibly modulate mammalian calcium channels.Read moreRead less