The discovery and validation of novel drug classes against parasites with the potential for major economic impacts. This project will develop a quality scientific and technological program in national priority areas, leading to a strong basic research, new concepts and the enhanced international collaborative links; strengthen links between basic and applied research, and academia and industry; develop excellence via pan-Australian collaborations, resulting in a more efficient use of resources i ....The discovery and validation of novel drug classes against parasites with the potential for major economic impacts. This project will develop a quality scientific and technological program in national priority areas, leading to a strong basic research, new concepts and the enhanced international collaborative links; strengthen links between basic and applied research, and academia and industry; develop excellence via pan-Australian collaborations, resulting in a more efficient use of resources in a national and international context; enhance the skills-base in biology, biotechnology and chemistry; increase global visibility with increased investment in Australian science; improve animal welfare and production via improved control of infectious diseases; producing commercial products with benefits to agricultural producers in regional & rural communities.Read moreRead less
Sustaining Australia's sheep industry under climate change: modelling Australia's sheep flock response to climatic and economic constraints. This project aims to provide a quantitative assessment of the impact of climate change and economic conditions on the Australian sheep industry. This will be achieved by constructing a robust dynamic model of the Australian sheep flock capable of integrating biophysical and economic constraints across regional and national scales. Using historical and proje ....Sustaining Australia's sheep industry under climate change: modelling Australia's sheep flock response to climatic and economic constraints. This project aims to provide a quantitative assessment of the impact of climate change and economic conditions on the Australian sheep industry. This will be achieved by constructing a robust dynamic model of the Australian sheep flock capable of integrating biophysical and economic constraints across regional and national scales. Using historical and projected biophysical and economic inputs it will enhance the capacity of the Australian sheep industry for strategic planning in the face of projected climate change. This capacity is being actively sought by the peak sheep industry bodies in conjunction with our industry partner the Bureau of Rural Sciences.Read moreRead less
Better bees for tomorrow: A proteomic and physiological characterization of male fertility in managed versus feral honeybees in Western Australia. The importance of honeybees for food production is often undervalued as they pollinate more than 80 crops of economic interest. However, honeybee populations are on a worldwide decline and the beekeepers struggle to survive economically. Australia has so far been spared of major collapses but this seems merely a question of time. The work proposed ini ....Better bees for tomorrow: A proteomic and physiological characterization of male fertility in managed versus feral honeybees in Western Australia. The importance of honeybees for food production is often undervalued as they pollinate more than 80 crops of economic interest. However, honeybee populations are on a worldwide decline and the beekeepers struggle to survive economically. Australia has so far been spared of major collapses but this seems merely a question of time. The work proposed initiates a close collaboration between the only honeybee-breeding organization in Western Australia and the University of Western Australia. Scientific research to ensure a future supply of managed and healthy honeybees is initiated to understand honeybee reproduction, diseases and immunity in more detail. The results are expected to be of interest for the entire Australian honeybee industry.Read moreRead less
Novel, Cost-Effective Methods for Measuring Methane Emissions from Grazing Livestock. Agriculture is second only to energy generation as a source of greenhouse gas emissions in Australia. Methane from cattle and sheep constitute 60% of these agricultural emissions. Their abatement is a win-win goal for the agricultural industry, reducing greenhouse emissions while increasing food efficiency. This project will develop a novel, cost- and-labour efficient method for on-farm measurements of the emis ....Novel, Cost-Effective Methods for Measuring Methane Emissions from Grazing Livestock. Agriculture is second only to energy generation as a source of greenhouse gas emissions in Australia. Methane from cattle and sheep constitute 60% of these agricultural emissions. Their abatement is a win-win goal for the agricultural industry, reducing greenhouse emissions while increasing food efficiency. This project will develop a novel, cost- and-labour efficient method for on-farm measurements of the emissions of methane from free-grazing cattle and sheep in their undisturbed environment. The method will be used to assess the dependence of methane emissions on factors such as diet and the efficacy of proposed methods for abatement of methane emissions, as well as providing improved data to the National Greenhouse Gas Inventory.Read moreRead less
Molecular approaches to solving current and emerging problems in the epidemiology and diagnosis of Marek's disease in Australia. Marek's disease (MD) is a ubiquitous viral disease of chickens that is currently controlled in meat chickens by blanket vaccination of all chickens. However, as has happened overseas, the efficacy of the HVT vaccine being used in Australia is breaking down resulting in subclinical and clinical losses due to MD. To assist industry deal with this situation we propose to ....Molecular approaches to solving current and emerging problems in the epidemiology and diagnosis of Marek's disease in Australia. Marek's disease (MD) is a ubiquitous viral disease of chickens that is currently controlled in meat chickens by blanket vaccination of all chickens. However, as has happened overseas, the efficacy of the HVT vaccine being used in Australia is breaking down resulting in subclinical and clinical losses due to MD. To assist industry deal with this situation we propose to develop novel molecular methods for the quantification of Marek's disease viruses (MDV) in the host and the environment, to use these methods to design effective early monitoring systems for MD in broilers that predict disease and performance outcomes, and to develop an epidemiological model that will predict the spread and severity of MD as failure of vaccinal protection progresses.Read moreRead less
Conservation management of seed-eating birds in the tropical savannas. Biodiversity loss in the savannas indicates unsustainable management. This research will enhance our abilities to effectively manage Australia's tropical savannas, as well as contributing to several State and Territory, Commonwealth and international obligations to maintain biodiversity. Understanding the processes underlying current declines will also make the effects of future management or environment changes easier to pre ....Conservation management of seed-eating birds in the tropical savannas. Biodiversity loss in the savannas indicates unsustainable management. This research will enhance our abilities to effectively manage Australia's tropical savannas, as well as contributing to several State and Territory, Commonwealth and international obligations to maintain biodiversity. Understanding the processes underlying current declines will also make the effects of future management or environment changes easier to predict. Retaining threatened species can benefit remote and regional communities through tourism, and also through the extra employment required to implement the management prescriptions that will be developed from this research.Read moreRead less
Molecular Interactions of Chemical Agents with Ion-Channel Proteins. With a minimal number of functional units (proteins) viruses are able to replicate. All of these proteins are possible antiviral targets. In this project we wil1 focus on a short protein called Vpu found in membranes of the HIV-1 virus and aim to analyse the interaction of potential pore blocking compounds. It is essential to know exactly where they sit and how the overall structure of Vpu is affected. For this enterprise we wi ....Molecular Interactions of Chemical Agents with Ion-Channel Proteins. With a minimal number of functional units (proteins) viruses are able to replicate. All of these proteins are possible antiviral targets. In this project we wil1 focus on a short protein called Vpu found in membranes of the HIV-1 virus and aim to analyse the interaction of potential pore blocking compounds. It is essential to know exactly where they sit and how the overall structure of Vpu is affected. For this enterprise we will use nuclear magnetic resonance (NMR) spectroscopy. This information will serve as a springboard for future investigations of virus membrane proteins.
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Individual animal management for grazing beef cattle. This research will significantly improve the ability of the Australian beef pastoral industry to stay competitive in the world market whilst improving animal welfare standards for the industry. Labour shortages in rural and regional areas of Australia are a major problem to the grazing industry. This research will not only help address the shortfall in unskilled labour but will provide the tools for addressing many human and animal welfare ....Individual animal management for grazing beef cattle. This research will significantly improve the ability of the Australian beef pastoral industry to stay competitive in the world market whilst improving animal welfare standards for the industry. Labour shortages in rural and regional areas of Australia are a major problem to the grazing industry. This research will not only help address the shortfall in unskilled labour but will provide the tools for addressing many human and animal welfare issues associated with cattle handling. Read moreRead less
Development of an Attenuated Infectious Laryngotracheitis Virus Vaccine. This project will develop novel methods for identification of genes involved in virulence of the important avian pathogen Infectious Laryngotracheitis Virus and produce an attenuated, antigenically marked infectious laryngotracheitis virus vaccine strain by specific disruption and deletion of two or more genes in the virusÕs genome.
Infectious laryngotracheitis is a major disease of chickens throughout the world, but curre ....Development of an Attenuated Infectious Laryngotracheitis Virus Vaccine. This project will develop novel methods for identification of genes involved in virulence of the important avian pathogen Infectious Laryngotracheitis Virus and produce an attenuated, antigenically marked infectious laryngotracheitis virus vaccine strain by specific disruption and deletion of two or more genes in the virusÕs genome.
Infectious laryngotracheitis is a major disease of chickens throughout the world, but current vaccines retain some capacity to cause disease. The development of novel attenuated vaccines will thus enhance control of this important disease of poultry.Read moreRead less
Evaluating Research Policy in Australian Broadacre Agriculture - Accounting for Interactions between the Beef, Sheep Meat, Wool, and Grains Industries. This project studies the returns from R&D investments in Australia's broadacre agricultural industries and equity in the funding of these investments. The contribution is to explicitly recognise the interaction across cattle, sheep and cropping enterprises, while past analyses have been single industry approach. Econometric models of multi-output ....Evaluating Research Policy in Australian Broadacre Agriculture - Accounting for Interactions between the Beef, Sheep Meat, Wool, and Grains Industries. This project studies the returns from R&D investments in Australia's broadacre agricultural industries and equity in the funding of these investments. The contribution is to explicitly recognise the interaction across cattle, sheep and cropping enterprises, while past analyses have been single industry approach. Econometric models of multi-output profit function for Australian broadacre agriculture and demand systems involving these products are estimated. A multi-industry equilibrium displacement model is developed to simulate the incidence of both costs and returns of agricultural R&D, with cross-industry interaction recognised. The project is likely to contribute to the way agricultural research is administered and funded in Australia.Read moreRead less