In vivo molecular imaging using engineered affinity reagents and fluorescent laser scanning confocal endomicroscopy. The goal of this project is to develop laser scanning confocal endomicroscopy as a tool for basic scientific discovery and rapid detection of disease biomarkers. The cutting-edge instrument and associated technologies will provide scientists with unprecedented access to dynamic biological processes as they occur in real-time. In addition, it will enable the development of virtual ....In vivo molecular imaging using engineered affinity reagents and fluorescent laser scanning confocal endomicroscopy. The goal of this project is to develop laser scanning confocal endomicroscopy as a tool for basic scientific discovery and rapid detection of disease biomarkers. The cutting-edge instrument and associated technologies will provide scientists with unprecedented access to dynamic biological processes as they occur in real-time. In addition, it will enable the development of virtual biopsies and instant diagnosis without the need for costly and time-consuming histopathological reports. Thus, it will not only drive transformative research but also transform health care delivery. It will also be a major boost to the Australian biotechnology industry with potential for enormous economic benefits.Read moreRead less
Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible ....Insight from Darkness: Nanophotonics for real-time phase imaging. This project aims to develop ultrathin surfaces patterned on the nanoscale for extracting information from optical wavefields. These devices can be designed to provide real-time phase contrast imaging of transparent objects. This capability would open up the possibility of live-cell imaging with no expensive optical components and no, or minimal, computational post-processing. The planar configuration is designed to be compatible with next-generation lab-on-a-chip technologies and permit rapid throughput diagnostics with potential applications in biomedicine and materials science. Expected project outcomes may also underpin fundamental advances in understanding the interaction of light with nanostructures.Read moreRead less