Stuctural analysis of RNA polymerase elongation complexes. RNA polymerase (RNAP) is an essential enzyme in all living cells. Its role is to convert the genetic information stored in genes into a message that can be converted into protein. Many additional factors are required to ensure that this enzyme functions correctly in the cell. The aim of this project is to obtain structural information on a bacterial RNAP complexed with an essential transcription factor called NusA. Using this information ....Stuctural analysis of RNA polymerase elongation complexes. RNA polymerase (RNAP) is an essential enzyme in all living cells. Its role is to convert the genetic information stored in genes into a message that can be converted into protein. Many additional factors are required to ensure that this enzyme functions correctly in the cell. The aim of this project is to obtain structural information on a bacterial RNAP complexed with an essential transcription factor called NusA. Using this information, plus data already obtained on the structure of this enzyme complexed with another essential factor called sigma, we will design small molecules to inhibit the interaction of these essential factors with polymerase. These molecules will serve as leads for the development of new antibiotics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668439
Funder
Australian Research Council
Funding Amount
$730,000.00
Summary
Elemental and Structural Analysis Facility Comprising a FTICR Mass Spectrometer and a CHNS Analyser. The determination of molecular structure is important in many fields of chemistry, biochemistry and material science. Without such determinations much chemical research would be viewed as incomplete and rendered unpatentable as well as unpublishable. The two state-of-the-art instruments to be purchased will improve the ability of a wide cross-section of researchers to rapidly characterize compoun ....Elemental and Structural Analysis Facility Comprising a FTICR Mass Spectrometer and a CHNS Analyser. The determination of molecular structure is important in many fields of chemistry, biochemistry and material science. Without such determinations much chemical research would be viewed as incomplete and rendered unpatentable as well as unpublishable. The two state-of-the-art instruments to be purchased will improve the ability of a wide cross-section of researchers to rapidly characterize compounds important in fields as varied as medicinal chemistry, material science and geosciences. All types of chemical research, from fundamental to applied, will benefit from these instruments with clear and positive implications regarding societal impact.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237664
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT- ....High Resolution Mass Spectrometer for (MS)n Chemical Characterisation. A Fourier transform ion cyclotron resonance ("FT-ICR") mass spectrometer equipped with electrospray ionisation (ESI) plus a "benchtop" matrix assisted laser desorption ionisation time of flight (MALDI-TOF) mass spectrometer are required to support the research of ca 28 research groups, including 44 postdoctoral fellows, and 138 honours and postgraduate students. By means of its high resolution and (MS)n capabilities, the FT-ICR-MS will provide key structural information on a wide range of synthetic and natural chemical substances, including sequence (e.g. peptides) and fragmentation patterns, while the MALDI-TOF instrument will be used primarily for high through-put proteomic analyses.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882977
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Enhanced NMR Research, Characterisation and Analysis Facility. Studying molecular species is at the heart of chemistry and biochemistry and fundamental to improving our understanding of molecular mechanisms and interactions. This becomes important for elucidating aspects of biological function, medicinal and pharmaceutical chemistry, materials science and synthetic methodology, which all underpin health and technology advances in Australia. The infrastructure will support projects involving fun ....Enhanced NMR Research, Characterisation and Analysis Facility. Studying molecular species is at the heart of chemistry and biochemistry and fundamental to improving our understanding of molecular mechanisms and interactions. This becomes important for elucidating aspects of biological function, medicinal and pharmaceutical chemistry, materials science and synthetic methodology, which all underpin health and technology advances in Australia. The infrastructure will support projects involving fundamental and strategic research spanning nanotechnology and the biological and materials sciences to industry-oriented projects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453426
Funder
Australian Research Council
Funding Amount
$235,000.00
Summary
Access for Australian Researchers to Advanced Neutron Beam Techniques. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Australi ....Access for Australian Researchers to Advanced Neutron Beam Techniques. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Australia's partnership with the world's most intense neutron source, ISIS in the UK, in order to sustain the considerable Australian scientific momentum which now relies on ISIS.
The outcomes will be new science that cannot be generated solely within Australia.
Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882725
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
Access for Australian Researchers to Advanced Neutron Beam Techniques. The major national benefit will be access, by peer review, to the 35 specialised instruments at the world's leading pulsed Neutron and Muon source, ISIS. This complements the access to the eight neutron instruments that will operate at the Australian Reactor OPAL. This will support (or enable) high quality research into areas as diverse as materials development, mineral processing and aspects of biological and medical scien ....Access for Australian Researchers to Advanced Neutron Beam Techniques. The major national benefit will be access, by peer review, to the 35 specialised instruments at the world's leading pulsed Neutron and Muon source, ISIS. This complements the access to the eight neutron instruments that will operate at the Australian Reactor OPAL. This will support (or enable) high quality research into areas as diverse as materials development, mineral processing and aspects of biological and medical science. It will facilitate international collaborations that are important for both research and post-graduate student training.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668044
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
Access for Australian Researchers to Advanced Neutron Beam Techniques. The access to ISIS is of strategic benefit to Australia. In the 'run up' to the Replacement Research Reactor that benefit will be increased because of the current upgrade to ISIS and the imminent construction of a second target station to provide the world's best 'cold neutron' facilities.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346812
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
Access for Australian Researchers to Advanced Neutron-Beam Techniques. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Australi ....Access for Australian Researchers to Advanced Neutron-Beam Techniques. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Australia's partnership with the world's most intense neutron source, ISIS in the UK, in order to sustain the considerable Australian scientific momentum which now relies on ISIS.
The outcomes will be new science that cannot be generated solely within Australia.
Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560721
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
Access for Australian Researchers to Advanced Neutron Beam Techniques. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Australi ....Access for Australian Researchers to Advanced Neutron Beam Techniques. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Australia's partnership with the world's most intense neutron source, ISIS in the UK, in order to sustain the considerable Australian scientific momentum which now relies on ISIS.
The outcomes will be new science that cannot be generated solely within Australia.
Read moreRead less