Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science an ....Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science and technology infrastructure within Australia, taking it into original and exciting directions, contribute to training young Australian scientists and students, as well as enhance Australia's competitive position in the field of nanobiotechnology.Read moreRead less
Bacterial Proteomics: From Cell Division to Novel Antibiotic Targets. When a cell divides it is essential that each newborn cell gets a complete copy of the DNA. To ensure that this happens, cell division must be tightly controlled. It is not known how this occurs in bacteria. However, if we knew what molecules were involved in this control, we could target them to kill harmful bacteria. This project aims to identify such regulatory molecules as candidate targets for antimicrobial agents, with a ....Bacterial Proteomics: From Cell Division to Novel Antibiotic Targets. When a cell divides it is essential that each newborn cell gets a complete copy of the DNA. To ensure that this happens, cell division must be tightly controlled. It is not known how this occurs in bacteria. However, if we knew what molecules were involved in this control, we could target them to kill harmful bacteria. This project aims to identify such regulatory molecules as candidate targets for antimicrobial agents, with a view to developing powerful, novel antibiotics to protect us from the imminent threat of bioterrorism and antibiotic-resistant bacteria.
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Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for l ....Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for liposomes. This provides a significant PhD training opportunity and brings an international focus to the development of planar patch-clamp electrophysiology in Australia. The project has significant commercial potential by developing both the planar patch-clamp electrophysiology techniques for liposomes and producing a novel biomimetic mechanosensitive biosensor.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775587
Funder
Australian Research Council
Funding Amount
$532,000.00
Summary
Correlating Genomics and Proteomics for Systems Biology: integrating the '-omics'. Acquisition of the infrastructure requested will maintain and extend the expertise developed by researchers in NSW and will allow retention and attraction of leading researchers who can contribute to understanding how genes and proteins interact in the development of the organism - the central focus of systems biology. The enhancement of the facility will allow a better understanding of biomolecular interactions ....Correlating Genomics and Proteomics for Systems Biology: integrating the '-omics'. Acquisition of the infrastructure requested will maintain and extend the expertise developed by researchers in NSW and will allow retention and attraction of leading researchers who can contribute to understanding how genes and proteins interact in the development of the organism - the central focus of systems biology. The enhancement of the facility will allow a better understanding of biomolecular interactions in health and disease, providing both community and national benefits. The focus of this LIEF application is to provide infrastructure platforms for the study of the systems biology of organisms and additional capacity by the facility for the expected increased demand for this technology in this new area. Read moreRead less
Special Research Initiatives - Grant ID: SR0354839
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Transforming Knowledge Spaces: Open Technologies for Research Collaboration and Research Communication
. Technology has the potential to transform the means for scholarly collaboration and communication. Our proposal will achieve this potential, by deploying open source infrastructures to create new communication platforms. The Initiative will itself use collaborative writing systems to construct and energise the Network, which will match researchers requiring these new technologies with thos ....Transforming Knowledge Spaces: Open Technologies for Research Collaboration and Research Communication
. Technology has the potential to transform the means for scholarly collaboration and communication. Our proposal will achieve this potential, by deploying open source infrastructures to create new communication platforms. The Initiative will itself use collaborative writing systems to construct and energise the Network, which will match researchers requiring these new technologies with those who have the skills to build them. The outcomes will be an increase in the efficiency of traditional research collaborations as well as new kinds of collaboration and communication, for researchers and consumers of research across a range of disciplines.Read moreRead less
Special Research Initiatives - Grant ID: SR0354538
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Enabling Sciences Education (EnSE) Research Network. The Network aims to ensure the long-term ability of Australians to excel in scientific and technological innovation at all levels of community activity. This will be achieved by establishing significant and ambitious research agendas for improving the teaching and learning of Mathematics, Science and Technology in primary, secondary and tertiary education sectors. Of significance will be the productive synergies flowing from uniting, across ....Enabling Sciences Education (EnSE) Research Network. The Network aims to ensure the long-term ability of Australians to excel in scientific and technological innovation at all levels of community activity. This will be achieved by establishing significant and ambitious research agendas for improving the teaching and learning of Mathematics, Science and Technology in primary, secondary and tertiary education sectors. Of significance will be the productive synergies flowing from uniting, across the three disciplines, Australia's most outstanding, experienced and dedicated researchers with new and mid-career colleagues. Expected outcomes include a diverse but cohesive and collaborative research community that provides international leadership in helping students achieve their full potential. Read moreRead less
Improving university teaching: Creating strategies and tools to support the design process. This project will create strategies and tools to help university teachers design effective online learning experiences. Excellence in online education is important to Australia, socially and economically. Social benefits come from greater participation and graduates better equipped to contribute to their communities. Economic benefits come from graduates with skills and knowledge to be flexible, adaptable ....Improving university teaching: Creating strategies and tools to support the design process. This project will create strategies and tools to help university teachers design effective online learning experiences. Excellence in online education is important to Australia, socially and economically. Social benefits come from greater participation and graduates better equipped to contribute to their communities. Economic benefits come from graduates with skills and knowledge to be flexible, adaptable and productive in a dynamic workplace. As high quality online education providers, Australian universities will be more competitive in the international education market. This project will raise the profile of Australian research and lead to new commercial ventures through the development of innovative technologies for online learning.Read moreRead less
The Fine Tuned Physiology of Microaerophilic Gastric Spirilla. The aim of the project is to understand the molecular basis of fundamental properties of the physiology of enterogastric spiral bacteria of the genera Campylobacter and Helicobacter. The characteristics of these obligate microaerophiles which will be investigated are their aerobic respiratory chains, the special metabolites and enzymes involved in thiol-disulphide redox balance, and their essential requirement for carbon dioxide. Mic ....The Fine Tuned Physiology of Microaerophilic Gastric Spirilla. The aim of the project is to understand the molecular basis of fundamental properties of the physiology of enterogastric spiral bacteria of the genera Campylobacter and Helicobacter. The characteristics of these obligate microaerophiles which will be investigated are their aerobic respiratory chains, the special metabolites and enzymes involved in thiol-disulphide redox balance, and their essential requirement for carbon dioxide. Microaerobes include some bacteria, archea and protozoa. Realisation of the widespread habitats and importance of microaerophiles, has led recently to a vigorous interest in understanding their physiology. Knowledge of the basic properties of microaerophily has potential applications to Environmental Microbiology, Agriculture, Industrial Microbiology, Veterinary Science and Medicine.Read moreRead less
Generating Science Content Knowledge through Digital Animation in a Knowledge-building Community of Preservice Teachers. Sustaining Australia's growth and prosperity is dependent on continuous innovation in the teaching of science. Yet science is one of the least taught subjects in the primary curriculum because teachers lack content knowledge and confidence. This research engages preservice primary teachers in using new technologies to develop their understanding of science content knowledge th ....Generating Science Content Knowledge through Digital Animation in a Knowledge-building Community of Preservice Teachers. Sustaining Australia's growth and prosperity is dependent on continuous innovation in the teaching of science. Yet science is one of the least taught subjects in the primary curriculum because teachers lack content knowledge and confidence. This research engages preservice primary teachers in using new technologies to develop their understanding of science content knowledge through digital animation and to collaborate with other preservice teachers interstate and internationally. The products and processes of digital animation will help maintain and expand Australia's base as a knowledge economy as well as provide a social benefit of improved science teaching in schools. Read moreRead less
Analyzing and supporting cooperation management in online learning communities. Australian companies, universities and other organizations are competing with other nations in the ?knowledge market?, and given the size of Australia's population compared to many of its competitors, keeping a position at the forefront of knowledge production and innovation has become an economic necessity. Communities of practice and other forms of collaborative teams are becoming important as producers and dissemi ....Analyzing and supporting cooperation management in online learning communities. Australian companies, universities and other organizations are competing with other nations in the ?knowledge market?, and given the size of Australia's population compared to many of its competitors, keeping a position at the forefront of knowledge production and innovation has become an economic necessity. Communities of practice and other forms of collaborative teams are becoming important as producers and disseminators of knowledge and social capital. Our research will help such knowledge producing entities to make optimal use of modern communication media, employing elements of 'smart? technologies. Research outcomes will contribute to the design and support of knowledge building communities in form of guidelines and software tools.Read moreRead less