Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100043
Funder
Australian Research Council
Funding Amount
$435,279.00
Summary
High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super ....High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super-solution imaging of single molecules in live cells. This facility will provide capability for researchers pursuing industry transformation and other initiatives in the development of advanced materials, biomolecular sciences, nanotechnology, photonics and device engineering.Read moreRead less
Smart Bungs for wine monitoring. 'Smart Bung' sensors will use optical fibres to monitor wine production using only nano- to microlitre-scale volumes, significantly reducing wastage and improving quality. They will serve as 'early warning devices' and will ensure that Australia's wine industry maintains its outstanding international reputation for excellence and innovation.
Discovery Early Career Researcher Award - Grant ID: DE150101196
Funder
Australian Research Council
Funding Amount
$403,536.00
Summary
Elucidation and characterisation of the misfolded protein interactome. Correct expression, folding, and clearance of proteins are critical for all cell functions. However, cell stresses and aging can cause protein balance mechanisms to become overloaded, resulting in the misfolding and aggregation of proteins. Understanding the mechanisms by which protein aggregation occurs and how to prevent the process have become major scientific challenges. This project aims to gain unprecedented insights in ....Elucidation and characterisation of the misfolded protein interactome. Correct expression, folding, and clearance of proteins are critical for all cell functions. However, cell stresses and aging can cause protein balance mechanisms to become overloaded, resulting in the misfolding and aggregation of proteins. Understanding the mechanisms by which protein aggregation occurs and how to prevent the process have become major scientific challenges. This project aims to gain unprecedented insights into the interactors, effectors and fate of misfolded protein aggregates within cells, using new, cutting-edge, catalytic-tagging biochemical tools. Critical interactions will be investigated for their roles in protein aggregation cell death, and in whether modulation of the interaction can also mitigate or reverse the process.Read moreRead less
Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk ass ....Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk assessment. This is intended to be achieved by developing and validating high-throughput in vitro toxicity screening platforms for manufactured nanoparticles. The approach is based on advanced lab-on-a-chip microfluidic technologies. The predictive power of the platform will be refined and optimised via ex-vivo and in-vivo models.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100614
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Terahertz metamaterial waveguides: a platform to create the next generation of compact THz devices. This project will make terahertz waveguide-based devices by exploiting metamaterials, man-made composite materials capable of controlling light in new ways. This project will build hollow-core metamaterial waveguides, where the large dimension (a few millimetres) of current rigid waveguides will be reduced to a few tens of microns. This project will demonstrate tuneable spectral filtering using th ....Terahertz metamaterial waveguides: a platform to create the next generation of compact THz devices. This project will make terahertz waveguide-based devices by exploiting metamaterials, man-made composite materials capable of controlling light in new ways. This project will build hollow-core metamaterial waveguides, where the large dimension (a few millimetres) of current rigid waveguides will be reduced to a few tens of microns. This project will demonstrate tuneable spectral filtering using these novel waveguides, leading to realisation of the world's first hollow-core waveguide-based metamaterial device. The outcome will have a profound impact on the next generation of terahertz devices, high resolution imaging and high sensitivity biosensors, which are indispensable tools for many disciplines including biology, medicine, forensic and public safety.Read moreRead less
Molecular insights into bacterial metal ion homeostasis and toxicity. This project aims to measure bacterial cellular metal concentrations, elucidate mechanisms cells use to adapt to changing extracellular metal concentrations, and reveal the molecular targets of metal toxicity. Metal ions are essential to all forms of life, and half of all proteins use metal ions for cellular chemical processes. However, how cells precisely balance sufficient metal ions for essential cellular chemistry without ....Molecular insights into bacterial metal ion homeostasis and toxicity. This project aims to measure bacterial cellular metal concentrations, elucidate mechanisms cells use to adapt to changing extracellular metal concentrations, and reveal the molecular targets of metal toxicity. Metal ions are essential to all forms of life, and half of all proteins use metal ions for cellular chemical processes. However, how cells precisely balance sufficient metal ions for essential cellular chemistry without accumulating a toxic excess (metal homeostasis) is poorly understood. Discovering the roles of metal ions in bacterial cells will be key to defining the chemical biology of living systems and will provide information essential to understanding how microbes adapt to changing environments.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100736
Funder
Australian Research Council
Funding Amount
$362,446.00
Summary
High performing multifunctional silicon nanomaterials for bio-applications. This project aims to develop high-performance, multifunctional silicon nanomaterials, and to understand their physicochemical properties for bio-imaging. A range of high-quality multifunctional silicon-based bio-probes with novel fluorescent and magnetic properties will be developed for enhancing bio-imaging. The outcomes of the project will further strengthen Australia’s leading position in the targeted areas of Advance ....High performing multifunctional silicon nanomaterials for bio-applications. This project aims to develop high-performance, multifunctional silicon nanomaterials, and to understand their physicochemical properties for bio-imaging. A range of high-quality multifunctional silicon-based bio-probes with novel fluorescent and magnetic properties will be developed for enhancing bio-imaging. The outcomes of the project will further strengthen Australia’s leading position in the targeted areas of Advanced Materials and Nanotechnology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100250
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Opto-acoustic metasurfaces. This project aims to develop efficient nanoscale light and sound sources and merge them on an extra-thin surface. Interactions between light and sound waves at the macroscopic scale are used every day, such as in non-destructive testing and contact-less imaging. However, research into nanoscale light-sound interactions is new and has not realised its full potential. This project intends to develop ultra-compact sources of light and sound, tune them effectively, harnes ....Opto-acoustic metasurfaces. This project aims to develop efficient nanoscale light and sound sources and merge them on an extra-thin surface. Interactions between light and sound waves at the macroscopic scale are used every day, such as in non-destructive testing and contact-less imaging. However, research into nanoscale light-sound interactions is new and has not realised its full potential. This project intends to develop ultra-compact sources of light and sound, tune them effectively, harness them simultaneously, and convert one to another efficiently, all crucial for real-world applications. This research is expected to improve technologies that use light and sound, including microscopy and spectroscopy.Read moreRead less