Microbial infestation of pre-painted steel building materials: chemical and microbial characterization, model development and control strategies. Coated steel building materials are a multi-billion dollar Australian industry. Microorganisms form slime layers on those materials, which are unsightly and reduce their energy benefits. The project will identify the problem organisms, the factors that facilitate their growth and will develop novel biofilm resistant, functional building materials.
Investigating a new way in which diet impacts animal biology. This project aims to investigate the importance of a new way in which diet can alter animal biology. High fat or high sugar diets increase the binding of products of metabolism to chromosomes, which can completely alter the way that DNA is packaged and read. This project will use cell culture, rodent and fly models to identify the regions of the genome that are most affected by the new process. The project will also determine whether ....Investigating a new way in which diet impacts animal biology. This project aims to investigate the importance of a new way in which diet can alter animal biology. High fat or high sugar diets increase the binding of products of metabolism to chromosomes, which can completely alter the way that DNA is packaged and read. This project will use cell culture, rodent and fly models to identify the regions of the genome that are most affected by the new process. The project will also determine whether the cell is harmed, or in fact harnesses the process to control development or metabolism. This project has implications for our understanding of the ways in which genes interact with the environment especially in times of change.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100122
Funder
Australian Research Council
Funding Amount
$620,000.00
Summary
Returning WA Rapid Acquisition Fluorescent Microscopy to the cutting edge. The equipment proposal aims to establish West Australia's only super-rapid-speed, high throughput confocal microscopy facility. The technology will provide researchers in biotechnology, medicine, environmental biology and agriculture with contemporary state-of-art opportunities to analyse living cells and/or large-area tissue specimens in three-dimensions with the highest possible speed and high-resolution. West Australia ....Returning WA Rapid Acquisition Fluorescent Microscopy to the cutting edge. The equipment proposal aims to establish West Australia's only super-rapid-speed, high throughput confocal microscopy facility. The technology will provide researchers in biotechnology, medicine, environmental biology and agriculture with contemporary state-of-art opportunities to analyse living cells and/or large-area tissue specimens in three-dimensions with the highest possible speed and high-resolution. West Australia hosts 1 twelve-year old historic rapid-acquisition confocal microscope that is heavily subscribed, no longer manufactured and prone to regular, prolonged, costly breakdowns. Accessing high-speed confocal systems in other states is not a viable option putting WA-based researchers at a significant disadvantage.Read moreRead less
Creating evidence-based public open space standards for apartment residents. This project aims to examine how to create public open space for apartment residents. It will (1) identify how apartment dwellers use public open space, including which spaces are used and why; and (2) test whether public open space use compensates for reduced apartment/building space. With less private space, apartment residents are assumed to rely on public spaces for physical, social and recreational activities. Yet ....Creating evidence-based public open space standards for apartment residents. This project aims to examine how to create public open space for apartment residents. It will (1) identify how apartment dwellers use public open space, including which spaces are used and why; and (2) test whether public open space use compensates for reduced apartment/building space. With less private space, apartment residents are assumed to rely on public spaces for physical, social and recreational activities. Yet little is known about which spaces they use and why, and what they would prefer. Expected outcomes include tailored, equitable evidence-based recommendations for public open space planning and apartment design guidelines. Benefits include the delivery of sustainable high-density precincts that cater to community needs.Read moreRead less
The importance of DNA methylation in response to environmental changes. This project aims to investigate the importance of DNA methylation, a process whereby gene expression can be altered without changes in the DNA code, in regulating our responses to environmental challenges. It plans to do so using well-validated models of adult exposure to high fat diet or psychological stress in mice and tissue-specific (liver and brain) deletion of the major methylation enzymes. It aims to compare function ....The importance of DNA methylation in response to environmental changes. This project aims to investigate the importance of DNA methylation, a process whereby gene expression can be altered without changes in the DNA code, in regulating our responses to environmental challenges. It plans to do so using well-validated models of adult exposure to high fat diet or psychological stress in mice and tissue-specific (liver and brain) deletion of the major methylation enzymes. It aims to compare functional, gene expression and methylation status after such challenges in intact and methylase deleted animals to determine how vital this process really is. This work has major implications for our understanding of epigenetics, and the ways in which genes interact with the environment especially in times of change.Read moreRead less
Mining voids and just transition: reimagining post-mining landscapes . This project aims to address the complex problem of how to deal with the long-term legacies of coal mining. Through a combination of ethnographic and Arts-Based Methods, the project will advance insight into how local communities in the Hunter Valley, NSW, experience socio-cultural impacts of environmental disturbance and mining legacies, particularly where final voids are present. It will generate new knowledge into potentia ....Mining voids and just transition: reimagining post-mining landscapes . This project aims to address the complex problem of how to deal with the long-term legacies of coal mining. Through a combination of ethnographic and Arts-Based Methods, the project will advance insight into how local communities in the Hunter Valley, NSW, experience socio-cultural impacts of environmental disturbance and mining legacies, particularly where final voids are present. It will generate new knowledge into potentials for reimagining post-mining landscapes and how such landscapes can support a just transition towards a post-mining future. Expected benefits include advancement of public discourses around mining legacies, research capacity building and theory development to support multi-stakeholder engagement and dialogue.Read moreRead less
Highly integrated miniaturised total analysis systems for pharmaceuticals in biological and environmental samples. This project will develop three unique chemical approaches that will each overcome a challenge to the creation of advanced miniaturised analytical devices with sample-in/answer-out capability. This will provide substantial improvements in speed, cost, portability, and operational simplicity and safety. New technology for analysing drugs in body fluids will be critical to enabling pe ....Highly integrated miniaturised total analysis systems for pharmaceuticals in biological and environmental samples. This project will develop three unique chemical approaches that will each overcome a challenge to the creation of advanced miniaturised analytical devices with sample-in/answer-out capability. This will provide substantial improvements in speed, cost, portability, and operational simplicity and safety. New technology for analysing drugs in body fluids will be critical to enabling people to closely match their pharmaceutical consumption with their individual requirements. The advance will have implications for all patients, particularly those in remote and rural Australian populations. The same technology is likely to find applications in environmental monitoring of emerging pharmaceutical pollutants. Read moreRead less
Health and sustainability: Australia in a global context. Sustainable population health in Australia is threatened by emerging global and domestic forces, including rising costs of energy and food, linked with climate change and migration. Domestic factors include a growing, ageing population. Better understanding of these forces will enhance national capacity to respond and adapt to these risks.
A landfill cover that generates electricity: a Microbial Fuel Cell application. Landfills account for over two per cent of Australia’s greenhouse emissions, dominating emissions from waste and wastewater. Methane emissions are inherent to landfills because waste cannot be permanently sealed until a landfill cell is full. In this project, a microbial fuel cell (MFC) landfill cover will be developed as a means of achieving full biogas capture, from the time that waste is placed. The MFC cover syst ....A landfill cover that generates electricity: a Microbial Fuel Cell application. Landfills account for over two per cent of Australia’s greenhouse emissions, dominating emissions from waste and wastewater. Methane emissions are inherent to landfills because waste cannot be permanently sealed until a landfill cell is full. In this project, a microbial fuel cell (MFC) landfill cover will be developed as a means of achieving full biogas capture, from the time that waste is placed. The MFC cover system would consist of a relatively thin and deformable granular graphite layer colonised by current generating methane oxidising microorganisms, overlain by a proton exchange membrane and steel mesh as the anode layer. The MFC cover will provide the benefit of power generation as well as more complete greenhouse gas mitigation. Read moreRead less
Development of new and high precision noble gas techniques for dating Quaternary volcanic rocks and surfaces: a Thermochronology and Noble Gas Geochronology and Geochemistry Organisation initiative. This project will calibrate noble gas dating methods, providing powerful tools for dating young volcanic rocks, eroded or buried surfaces and glacier/ice retreat. This research has considerable social, national and economic benefits for research training, volcanic hazard assessment, landscape evoluti ....Development of new and high precision noble gas techniques for dating Quaternary volcanic rocks and surfaces: a Thermochronology and Noble Gas Geochronology and Geochemistry Organisation initiative. This project will calibrate noble gas dating methods, providing powerful tools for dating young volcanic rocks, eroded or buried surfaces and glacier/ice retreat. This research has considerable social, national and economic benefits for research training, volcanic hazard assessment, landscape evolution, paleoclimate change and mineral exploration.Read moreRead less