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Advancing x-ray imaging into new dimensions using interferometry and phase-space tomography. Synchrotron science and nanofabrication technologies are priority investment areas for most industrial countries including Australia. This research program takes advantages of recent progress in these fields and aims to advance x-ray imaging techniques of high sensitivity and low radiation dose and retrieve all extractable information of an object encoded in a wavefield. The development of these techniqu ....Advancing x-ray imaging into new dimensions using interferometry and phase-space tomography. Synchrotron science and nanofabrication technologies are priority investment areas for most industrial countries including Australia. This research program takes advantages of recent progress in these fields and aims to advance x-ray imaging techniques of high sensitivity and low radiation dose and retrieve all extractable information of an object encoded in a wavefield. The development of these techniques is critical to future opportunities of frontier discoveries of the biological, nano and atomic world. Its application includes structural biology, medical diagnosis, biomedicine, material sciences and many other fields.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100010
Funder
Australian Research Council
Funding Amount
$720,000.00
Summary
A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the ....A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the nation's research priorities. It will enable: fundamental studies of cancer, neural diseases and immune disorders; the development of frontier technologies, such as smart nanomaterials, biosensors and targeted drug delivery; and applied research to help plants and soils adapt to climate variability, and to increase sustainable use of water.Read moreRead less
In-situ Scanning Probe Microscopy of biological redox processes: nanoscale structure and morphology. The science behind this project underpins the development of nanobiotechnology. Immediate applications foreseen, are the development of biosensors and diagnostic devices based on our intimate knowledge of the nature of the protein attachment to a surface. Use of synthetic membranes to create biomimetic surfaces will impact significantly on our understanding of the role and contribution membranes ....In-situ Scanning Probe Microscopy of biological redox processes: nanoscale structure and morphology. The science behind this project underpins the development of nanobiotechnology. Immediate applications foreseen, are the development of biosensors and diagnostic devices based on our intimate knowledge of the nature of the protein attachment to a surface. Use of synthetic membranes to create biomimetic surfaces will impact significantly on our understanding of the role and contribution membranes have on protein structure, function hence disease.Read moreRead less
Correlation between surface force and morphology of self-assembled monolayer. As a most potential solid support for biological molecules without denaturing their functions, gold thiol self-assembled monolayers (SAMs) have been studied extensively for surface fabrication. In this project we will prepare functional monolayers using newly synthesized thiol derivatives, evaluate correlation between surface force and surface morphology of the SAMs using the surface forces apparatus, and optimize the ....Correlation between surface force and morphology of self-assembled monolayer. As a most potential solid support for biological molecules without denaturing their functions, gold thiol self-assembled monolayers (SAMs) have been studied extensively for surface fabrication. In this project we will prepare functional monolayers using newly synthesized thiol derivatives, evaluate correlation between surface force and surface morphology of the SAMs using the surface forces apparatus, and optimize the condition to fabricate biological devices such as immune sensors.Read moreRead less
Opto-Microfluidics: A Rapid and Sensitive Platform for Biological Diagnostics. One in four people above 25 years suffer from diabetes-related diseases in Australia, with an associated economic cost exceeding $3 billion a year. A microdevice for continuous glucose monitoring would help patients to manage the disease, leading to huge individual, clinical and societal benefits. Life expectancy is expected to increase along with quality of life. Integration of the microdevice with insulin delivery w ....Opto-Microfluidics: A Rapid and Sensitive Platform for Biological Diagnostics. One in four people above 25 years suffer from diabetes-related diseases in Australia, with an associated economic cost exceeding $3 billion a year. A microdevice for continuous glucose monitoring would help patients to manage the disease, leading to huge individual, clinical and societal benefits. Life expectancy is expected to increase along with quality of life. Integration of the microdevice with insulin delivery would realise an 'artificial pancreas', revolutionising the management and treatment of the disease. The technology will also provide a platform for other point-of-care medical diagnostic devices, which will allow early participation in this emerging market and cement Australia's position in bionanotechnology.Read moreRead less