Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100043
Funder
Australian Research Council
Funding Amount
$435,279.00
Summary
High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super ....High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super-solution imaging of single molecules in live cells. This facility will provide capability for researchers pursuing industry transformation and other initiatives in the development of advanced materials, biomolecular sciences, nanotechnology, photonics and device engineering.Read moreRead less
Novel concepts to engineer low cost blood diagnostics. Novel concepts to engineer low cost blood diagnostics. This project aims to deliver the next generation of on-paper blood diagnostics: cheap, fast, easy to use, reliable, specific and robust. Transformational methods in on-paper and thread-based diagnostics could make indirect and weak blood typing possible. This project expects on-paper testing for fibrinogen to assess clotting capability could revolutionise treatment of massive blood loss. ....Novel concepts to engineer low cost blood diagnostics. Novel concepts to engineer low cost blood diagnostics. This project aims to deliver the next generation of on-paper blood diagnostics: cheap, fast, easy to use, reliable, specific and robust. Transformational methods in on-paper and thread-based diagnostics could make indirect and weak blood typing possible. This project expects on-paper testing for fibrinogen to assess clotting capability could revolutionise treatment of massive blood loss. Expected results of this project are a new class of on-paper and thread-based diagnostic tests with enhanced sensitivity, readability and lower cost, which could significantly affect trauma, rural medicine and developing nations.Read moreRead less
Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk ass ....Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk assessment. This is intended to be achieved by developing and validating high-throughput in vitro toxicity screening platforms for manufactured nanoparticles. The approach is based on advanced lab-on-a-chip microfluidic technologies. The predictive power of the platform will be refined and optimised via ex-vivo and in-vivo models.Read moreRead less
Early-Stage Medical Diagnostics by Plasmon-Mediated Gas Sensing. This project will investigate the use plasmonic absorption of light in metal nanostructures to activate the selective oxidation/reduction of a gas molecule on a semiconductor nanoparticle. This concept will be used with the aim of developing a sensing technique capable of measuring ultra-low concentrations (ppb) of breath markers for lung cancer detection. It is expected that porous sensing films of semiconductor and metal nanopart ....Early-Stage Medical Diagnostics by Plasmon-Mediated Gas Sensing. This project will investigate the use plasmonic absorption of light in metal nanostructures to activate the selective oxidation/reduction of a gas molecule on a semiconductor nanoparticle. This concept will be used with the aim of developing a sensing technique capable of measuring ultra-low concentrations (ppb) of breath markers for lung cancer detection. It is expected that porous sensing films of semiconductor and metal nanoparticles with well-defined light absorption properties will be fabricated. Superior selectivity will be achieved by matching the wavelength of the absorbed light with the required activation energy for oxidation/reduction. Successful outcomes will enable multi-analyte fingerprint identification by on-chip devices with applications ranging from portable medical diagnostics to national security.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100035
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Hyperpolarised gas functional lung and molecular imaging. This project will produce a polariser to generate magnetised gas for research with magnetic resonance imaging (MRI). This allows imaging of normal and abnormal lung ventilation and circulation in animal and humans. The use of these hyperpolarised gases can also be used to tag specific molecules and increase understanding of lung metabolism.
Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic erro ....Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic errors affecting thousands. This research tests a new method of assessing diagnostic skills based on how skilled operators respond to cues. This project will test how employees’ diagnostic skills change and whether this change corresponds to measures of organisational performance. This research is expected to provide organisations with a tool to pre-empt diagnostic errors that could minimise costs to the economy.Read moreRead less
Using the eye as a window to the central nervous system for improved drug testing. The annual cost of treating brain illnesses is US$250 billion. Each new drug costs about US$900 million to develop. This research will give Pfizer Pty Ltd, the project’s industry partner, a more efficient and direct way of testing whether drugs can get into and affect the brain. This will reduce the cost of drug development, which ultimately means cheaper drugs. The project will develop new technologies to put Aus ....Using the eye as a window to the central nervous system for improved drug testing. The annual cost of treating brain illnesses is US$250 billion. Each new drug costs about US$900 million to develop. This research will give Pfizer Pty Ltd, the project’s industry partner, a more efficient and direct way of testing whether drugs can get into and affect the brain. This will reduce the cost of drug development, which ultimately means cheaper drugs. The project will develop new technologies to put Australia at the forefront of neuropharmaceutical and neuroscience research. A new research platform will foster collaborations with the pharmaceutical industry both within Australia and overseas. This industrial link will promote a unique post-graduate experience by providing exposure to academic and industrial environments for Australian scientists.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC140100023
Funder
Australian Research Council
Funding Amount
$1,800,000.00
Summary
ARC Training Centre in Biodevices. ARC Training Centre in Biodevices. The Training Centre aims to assist Australian biodevice and diagnostics companies to develop the next generation of innovative and profitable products that address important healthcare needs in our communities. This will be achieved by addressing industry-specific challenges relating to the multidisciplinary nature of design and development in the biodevices and diagnostics sector; technology uptake and transfer to manufacturi ....ARC Training Centre in Biodevices. ARC Training Centre in Biodevices. The Training Centre aims to assist Australian biodevice and diagnostics companies to develop the next generation of innovative and profitable products that address important healthcare needs in our communities. This will be achieved by addressing industry-specific challenges relating to the multidisciplinary nature of design and development in the biodevices and diagnostics sector; technology uptake and transfer to manufacturing; the composition, maturity and size of local firms in the sector; and the development of high-level entrepreneurial skills for innovative industry researchers. The Training Centre will remove barriers to collaboration between universities and industry by delivering exceptional return on research investment.Read moreRead less
Nanodiamond in glass: a new approach to nanosensing. This work will develop optical materials enriched with diamond nanoparticles. This will enable the magnetic field sensitivity of diamond nanoparticles to be combined with the capacity of micro/nanostructured optical fibres to enhance the interaction of light with matter. The outcome will be tools for probing biological processes on the nanoscale.
Understanding progressive vision loss in the eye disease glaucoma. Glaucoma is the second leading cause of irreversible vision loss in elderly Australians, although determining treatment failure is currently very dif?cult. This project will radically improve the measurement of glaucoma progression and treatment failure. We will also address fundamental questions regarding how glaucoma destroys vision.