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Topography Optimisation of Implants for Enhancing Osseointegration. With recent increased life expectancy, the ratio of implant recipients to total population has dramatically increased. The project will address a critical issue in ensuring long-term success of prosthetic treatment. The proposed computational multiscale modelling will provide a sound scientific alternative means to optimisation of overall implant design including surface topography. The anticipated outcomes of this research will ....Topography Optimisation of Implants for Enhancing Osseointegration. With recent increased life expectancy, the ratio of implant recipients to total population has dramatically increased. The project will address a critical issue in ensuring long-term success of prosthetic treatment. The proposed computational multiscale modelling will provide a sound scientific alternative means to optimisation of overall implant design including surface topography. The anticipated outcomes of this research will help improve the quality of prosthetic therapy, and benefit our prosthodontic and orthopaedic professionals and their patients. The study clearly aligns with the national research goals of frontier technologies and maintaining good health.Read moreRead less
Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical pr ....Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical properties of this tissue will be of great benefit for the design of bio-inspired materials and be important for the development of advanced materials for which Australia already has an enviable reputation.Read moreRead less
Failure of Complex Biomechanical Structures. Layer structures are replete in biological systems, both natural and artificial. Issues concerning the lifetime of such systems are paramount to the quality of life and economic well being of our aging society. Our project will analyse damage in brittle layer systems that simulate dental crown structures. We are now at a critical point in the understanding of how these structures fail, and are beginning to make substantive predictions to improve des ....Failure of Complex Biomechanical Structures. Layer structures are replete in biological systems, both natural and artificial. Issues concerning the lifetime of such systems are paramount to the quality of life and economic well being of our aging society. Our project will analyse damage in brittle layer systems that simulate dental crown structures. We are now at a critical point in the understanding of how these structures fail, and are beginning to make substantive predictions to improve designs for prolonged life. The project is connected to the dental community and international crown material manufacturers through a broader NIH project in the USA. The improved materials and crown designs resulting from this project will have impact worldwide, including Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989859
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation. X-ray microtomography platforms are applicable to a wide diversity of research across many of the national research priority areas. The research outlined will provide insights into bone cancer and osteoporosis, promote breakthroughs in the understanding of tumour biology and drive new developments in novel biomaterials, all of which have significant national health benefits. In dentistr ....A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation. X-ray microtomography platforms are applicable to a wide diversity of research across many of the national research priority areas. The research outlined will provide insights into bone cancer and osteoporosis, promote breakthroughs in the understanding of tumour biology and drive new developments in novel biomaterials, all of which have significant national health benefits. In dentistry, research supported by this instrumentation will provide Australians with improvements to their dental health. Furthermore applications to industrial materials are providing Australian industries with better characterisation of their products that is leading to improved export performance and consequent improvement in Australia's balance of trade.Read moreRead less
Teeth tales: A culturally competent community intervention for child oral health in low SES area of urban Melbourne. Dental caries represent the highest burden of disease for pre-school children. Disadvantaged, refugee and migrant communities face an estimated increased prevalence of 60%. Community-based health solutions that are evidence based and cross-sectoral are urgently needed. The potential impact of improved child oral health on social, emotional and learning outcomes is compelling. The ....Teeth tales: A culturally competent community intervention for child oral health in low SES area of urban Melbourne. Dental caries represent the highest burden of disease for pre-school children. Disadvantaged, refugee and migrant communities face an estimated increased prevalence of 60%. Community-based health solutions that are evidence based and cross-sectoral are urgently needed. The potential impact of improved child oral health on social, emotional and learning outcomes is compelling. The child health and service change outcomes of this study will be of direct benefit to the community and will have clear applications for other culturally diverse local government areas in Australia and other developed countries. The findings will directly inform policy/funding decision making by Dental Health Services Victoria for Victorian families and services.Read moreRead less
Quantification of the Remineralisation of Enamel. This project has three specific aims:
1. To quantify the ultrastructure and mechanisms of remineralisation of enamel using scanning and transmission electron microscopy.
2. To determine the mechanical properties of remineralised tissue and compare with those of sound enamel.
3. To develop an in-vivo optical fibre probe for monitoring and quantifying the changes of mineralised carious tissue during remineralisation.
This project will enable ....Quantification of the Remineralisation of Enamel. This project has three specific aims:
1. To quantify the ultrastructure and mechanisms of remineralisation of enamel using scanning and transmission electron microscopy.
2. To determine the mechanical properties of remineralised tissue and compare with those of sound enamel.
3. To develop an in-vivo optical fibre probe for monitoring and quantifying the changes of mineralised carious tissue during remineralisation.
This project will enable patients prone to orthodontic induced root resorption to be identified and also to assist with validating repair of enamel tooth structure in a non-surgical manner. It is anticipated to result in the development of a novel fibre optic instrument with applications beyond dentistry.
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Failure modes in ceramic-based layer structures: Relevance to failure of dental crowns. With the aging of our population, issues concerning the lifetime of biological system are paramount to the quality of life and economic well being of our society. This project is closely linked to the development of prosthetic materials and structures that will improve performance and life of biomechanical devices, by providing better understanding to the mechanics of failure and failure origins of ceramic-ba ....Failure modes in ceramic-based layer structures: Relevance to failure of dental crowns. With the aging of our population, issues concerning the lifetime of biological system are paramount to the quality of life and economic well being of our society. This project is closely linked to the development of prosthetic materials and structures that will improve performance and life of biomechanical devices, by providing better understanding to the mechanics of failure and failure origins of ceramic-based dental crowns and restorations, and to develop materials that will withstand exacting conditions - in body fluids - over extended lifetimes. Crown replacement is by far the most widespread of all prosthetic procedures. This project promises to help bridge the gap between physical and medical science in Australia. Read moreRead less
Optimising transgene expression and stability for enhanced sugar yield and high-value sugar production in sugarcane. 'SugarBooster' technology has the potential to underpin a value-added sugarcane industry. Higher sucrose yield is a key to sustainable export profitability, and it makes the development of renewable biofuels from sugarcane more feasible. Isomaltulose has established health benefits for consumers and it is also attractive as a renewable starting material for industry. But it must c ....Optimising transgene expression and stability for enhanced sugar yield and high-value sugar production in sugarcane. 'SugarBooster' technology has the potential to underpin a value-added sugarcane industry. Higher sucrose yield is a key to sustainable export profitability, and it makes the development of renewable biofuels from sugarcane more feasible. Isomaltulose has established health benefits for consumers and it is also attractive as a renewable starting material for industry. But it must currently be produced by expensive fermentation. Efficient production in plants will open an increasing world market. This collaborative project is vital to bring these breakthrough technologies to reliable commercial implementation, in time to capture the economic benefits of the protected IP for Australia.Read moreRead less
Targeting and stabilizing proteins in sugar storage vacuoles for metabolic engineering in sugarcane. We have isolated a novel gene for an enzyme that efficiently converts sucrose into a product of much higher value. We have shown that the enzyme functions in sugarcane, a first example of the potential for new biosynthetic capacities in this highly productive crop. Because 90% of stored sucrose is in specialized vacuoles, the enzyme needs to be directed into these vacuoles, and made stable and ac ....Targeting and stabilizing proteins in sugar storage vacuoles for metabolic engineering in sugarcane. We have isolated a novel gene for an enzyme that efficiently converts sucrose into a product of much higher value. We have shown that the enzyme functions in sugarcane, a first example of the potential for new biosynthetic capacities in this highly productive crop. Because 90% of stored sucrose is in specialized vacuoles, the enzyme needs to be directed into these vacuoles, and made stable and active there. This is feasible by building on recent discoveries about vacuolar targeting in plants. The outputs include scientific understanding to underpin metabolic engineering in plants, and a profitable high-technology export industry for Australia.Read moreRead less
Effects of prosthesis design on bone remodelling and longevity of dental restorations. The project targets both the 'Promoting and Maintaining Good Health' and 'Advanced Materials' designated research priority areas. The research will underpin Australia's leading role on some emerging interdisciplinary frontiers of biomechanics, biomaterials, health sciences and biomedical software. The development of computer aided clinical plan will help optimise dental restorations for 'long-term success'. Th ....Effects of prosthesis design on bone remodelling and longevity of dental restorations. The project targets both the 'Promoting and Maintaining Good Health' and 'Advanced Materials' designated research priority areas. The research will underpin Australia's leading role on some emerging interdisciplinary frontiers of biomechanics, biomaterials, health sciences and biomedical software. The development of computer aided clinical plan will help optimise dental restorations for 'long-term success'. The benefit will be to improve the ongoing performance and longevity of dental restoration, which complies with the highly demanding national goal of 'ageing well'. The study will also provide a new means to improve the therapy effect for many young Australians' effort towards a 'healthy start to their life'.Read moreRead less