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Understanding how cells in the olfactory nerve prevent brain infection. The project hypothesis is that the phagocytic activity of olfactory ensheathing cells (OECs) is the key factor that prevents bacteria from accessing the brain via the olfactory nerve, and allows continuous regeneration of the olfactory nervous system. This project aims to investigate how OECs phagocytose bacteria and debris from degenerating axons in vivo, and determine key molecular mechanisms in the process. Thus, we will ....Understanding how cells in the olfactory nerve prevent brain infection. The project hypothesis is that the phagocytic activity of olfactory ensheathing cells (OECs) is the key factor that prevents bacteria from accessing the brain via the olfactory nerve, and allows continuous regeneration of the olfactory nervous system. This project aims to investigate how OECs phagocytose bacteria and debris from degenerating axons in vivo, and determine key molecular mechanisms in the process. Thus, we will characterise an unknown aspect of OEC biology that is neglected in the field. Intended outcomes include a paradigm shift that glial cells, and not circulatory immune cells, are the main defense against microbial invasion of the olfactory nerve. This is relevant for new therapies targeting neural infection/injury and antibiotic usage.Read moreRead less