Evolutionary genetics of bovid genomes over 60,000 years. This project will provide data critical for understanding the genetic background of modern cattle and bison, and how humans have shaped factors such as milk yield, growth rates and muscle mass. It will also reveal genes and genomic regions that were favoured in the domestication process, including those potentially linked to genes of commercial interest for future research. This pioneering ancient DNA approach will also be applicable to a ....Evolutionary genetics of bovid genomes over 60,000 years. This project will provide data critical for understanding the genetic background of modern cattle and bison, and how humans have shaped factors such as milk yield, growth rates and muscle mass. It will also reveal genes and genomic regions that were favoured in the domestication process, including those potentially linked to genes of commercial interest for future research. This pioneering ancient DNA approach will also be applicable to a variety of other domestic crops and animals. The unique temporal analysis of microevolution will provide crucial data for genetic research, and groundproof our attempts to analyse the timing and nature of human evolutionary history, major domestication events and inform conservation management.Read moreRead less
Liver fluke: improving disease control through understanding of parasite diversity, drug resistance and better diagnosis. The benefits from this research include: (i) development of knowledge that will allow a better use of existing drug formulations to protect livestock from fasciolosis, potentially generating economic benefits to Australian producers of up to $50-80m/year; (ii) improved application of new commercial therapies for fasciolosis in ruminants, improving producer prosperity; (iii) ....Liver fluke: improving disease control through understanding of parasite diversity, drug resistance and better diagnosis. The benefits from this research include: (i) development of knowledge that will allow a better use of existing drug formulations to protect livestock from fasciolosis, potentially generating economic benefits to Australian producers of up to $50-80m/year; (ii) improved application of new commercial therapies for fasciolosis in ruminants, improving producer prosperity; (iii) enhanced training opportunities for graduate students that will build human capacity in technologies such as molecular diagnostics which have a wide application across the animal sectors; (iv) enhancement of our capacity to respond to unexpected future threats in production animals.Read moreRead less
Embryo genomics for engineering change. The proposed research program will contribute to areas that are critically important for Australia, such as agriculture, animal biodiversity, biomedicine, human health and biosafety. By addressing the high economic losses due to early embryonic mortality in farm animals, results from this research will enhance the competitiveness of Australian agriculture and biomedical research. The establishment of a world class research Centre for Animal Biotechnology a ....Embryo genomics for engineering change. The proposed research program will contribute to areas that are critically important for Australia, such as agriculture, animal biodiversity, biomedicine, human health and biosafety. By addressing the high economic losses due to early embryonic mortality in farm animals, results from this research will enhance the competitiveness of Australian agriculture and biomedical research. The establishment of a world class research Centre for Animal Biotechnology at the University of Adelaide will create a major addition to the national research base. The Centre will develop technology platforms to support various groups across the entire Australian scientific community.Read moreRead less
Novel, Cost-Effective Methods for Measuring Methane Emissions from Grazing Livestock. Agriculture is second only to energy generation as a source of greenhouse gas emissions in Australia. Methane from cattle and sheep constitute 60% of these agricultural emissions. Their abatement is a win-win goal for the agricultural industry, reducing greenhouse emissions while increasing food efficiency. This project will develop a novel, cost- and-labour efficient method for on-farm measurements of the emis ....Novel, Cost-Effective Methods for Measuring Methane Emissions from Grazing Livestock. Agriculture is second only to energy generation as a source of greenhouse gas emissions in Australia. Methane from cattle and sheep constitute 60% of these agricultural emissions. Their abatement is a win-win goal for the agricultural industry, reducing greenhouse emissions while increasing food efficiency. This project will develop a novel, cost- and-labour efficient method for on-farm measurements of the emissions of methane from free-grazing cattle and sheep in their undisturbed environment. The method will be used to assess the dependence of methane emissions on factors such as diet and the efficacy of proposed methods for abatement of methane emissions, as well as providing improved data to the National Greenhouse Gas Inventory.Read moreRead less
Topical and cryoanaesthesia for livestock husbandry. The livestock industries contribute $15billion annually to Australia's economy, playing a vital role in rural communities. However we must respond to changing demands of our customers, by complementing our competitive disease-free advantage with welfare-conscious production systems. This project will address the threat of growing international demands for improved animal welfare in farming. We will provide research and technical solutions, pro ....Topical and cryoanaesthesia for livestock husbandry. The livestock industries contribute $15billion annually to Australia's economy, playing a vital role in rural communities. However we must respond to changing demands of our customers, by complementing our competitive disease-free advantage with welfare-conscious production systems. This project will address the threat of growing international demands for improved animal welfare in farming. We will provide research and technical solutions, providing pain mangement products for on-farm use that will reduce animal suffering during routine husbandry interventions. The project offers significant benefits for producers by protecting their industries against the threats of a welfare embargo on our livestock products. Read moreRead less
Synchronising phosphorus fertilisation with plant phosphorus demand: a tactic to reduce phosphorus transfer from land to water. Phosphorus loss from intensive pasture systems is a major issue internationally due to the pollution and nutrient enrichment of water ways. This study will examine how a strategy of synchronising phosphorus (P) fertiliser to periods of high P demand in ryegrass (Lolium perenne) may be used to improve the efficiency of P uptake and thereby reduce P losses in surface run ....Synchronising phosphorus fertilisation with plant phosphorus demand: a tactic to reduce phosphorus transfer from land to water. Phosphorus loss from intensive pasture systems is a major issue internationally due to the pollution and nutrient enrichment of water ways. This study will examine how a strategy of synchronising phosphorus (P) fertiliser to periods of high P demand in ryegrass (Lolium perenne) may be used to improve the efficiency of P uptake and thereby reduce P losses in surface runoff. Simple models will be used to identify the key risk factors associated with surface P loss in order to improve the sustainability of P fertiliser use in pasture systems.Read moreRead less
Subcellular co-localisation of interacting proteins that control maturation in mammalian eggs. The final maturation of mammalian eggs (oocytes) before fertilisation involves a cascade of interactions between protein kinases and phosphatases, the shuttling of these proteins between cytoplasm and nucleus, and microtubule assembly and disassembly. In this project we have proposed that interacting proteins involved in oocyte maturation are co-localised at subcellular sites in oocytes, in a strict t ....Subcellular co-localisation of interacting proteins that control maturation in mammalian eggs. The final maturation of mammalian eggs (oocytes) before fertilisation involves a cascade of interactions between protein kinases and phosphatases, the shuttling of these proteins between cytoplasm and nucleus, and microtubule assembly and disassembly. In this project we have proposed that interacting proteins involved in oocyte maturation are co-localised at subcellular sites in oocytes, in a strict temporal and spatial manner. The co-localisation of proteins in oocytes is considered a fundamental mechanism that ensures coordination of time-bound cellular events and proper preparation of oocytes for fertilisation and early embryo development. There are important implications for IVF and cloning by nuclear transfer.Read moreRead less
Identification of nuclear reprogramming factors in oocyte cytoplasm. The mature oocyte contains dominant factors that are capable of erasing tissue specific gene expression profiles of somatic cells. These reprogramming factors would be valuable for dedifferentiation of cells and for nuclear transfer in animal cloning. The research involves determination of reprogramming factors present in active cytoplasm following enucleation of the germinal vesicle, blockage of transcription and translation, ....Identification of nuclear reprogramming factors in oocyte cytoplasm. The mature oocyte contains dominant factors that are capable of erasing tissue specific gene expression profiles of somatic cells. These reprogramming factors would be valuable for dedifferentiation of cells and for nuclear transfer in animal cloning. The research involves determination of reprogramming factors present in active cytoplasm following enucleation of the germinal vesicle, blockage of transcription and translation, and timed cultures. The assays will involve maintenance of reprogramming ability and erasure of somatic gene transcription. By subtractive elimination the function of isolated proteins which are involved in reprogramming will be identified for potential recombinant production.Read moreRead less
New Membrane Methods to Extract Lactose From Waste Dairy Streams. Dairy processors throughout the world produce about 145,000,000 t of liquid whey per year. Lactose, the principle component in cheese whey, contributes a significant pollution problem for dairy processors. The aim of this Linkage Award application is to develop membranes that selectively extract the lactose. This requires the preparation of membrane carriers that transport the lactose through the membrane. The development of new a ....New Membrane Methods to Extract Lactose From Waste Dairy Streams. Dairy processors throughout the world produce about 145,000,000 t of liquid whey per year. Lactose, the principle component in cheese whey, contributes a significant pollution problem for dairy processors. The aim of this Linkage Award application is to develop membranes that selectively extract the lactose. This requires the preparation of membrane carriers that transport the lactose through the membrane. The development of new approaches and technologies for the isolation and purification of lactose from feed streams may lead to improved processes for manufacture of purified lactose or new lactose products.Read moreRead less
Development of an attenuated vaccine to control the emerging bovine respiratory pathogen Mycoplasma bovis. The project will develop an attenuated vaccine to control the emerging bovine respiratory pathogen Mycoplasma bovis. This pathogen is a major contributor to bovine pneumonia in the feedlot industry and improved control will reduce reliance on antibiotics in cattle production.