Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100047
Funder
Australian Research Council
Funding Amount
$380,000.00
Summary
Distributed facility for fragment based drug discovery. Distributed facility for fragment based drug discovery:
The facility aims to provide researchers with the ability to generate small molecules that modulate therapeutically and biologically important protein targets. Fragment-based drug design (FBDD) provides a rational approach to generate such biologically active compounds. The facility is designed to allow researchers throughout Australia to access the necessary infrastructure to underta ....Distributed facility for fragment based drug discovery. Distributed facility for fragment based drug discovery:
The facility aims to provide researchers with the ability to generate small molecules that modulate therapeutically and biologically important protein targets. Fragment-based drug design (FBDD) provides a rational approach to generate such biologically active compounds. The facility is designed to allow researchers throughout Australia to access the necessary infrastructure to undertake FBDD projects against a range of biologically important targets. The facility aims to enable access to high-throughput nuclear magnetic resonance spectroscopy and surface plasmon resonance, and to generate the capacity for automation in chemical synthesis and sample preparation to expedite the development of novel bioactive molecules. The development of better approaches to hit development may benefit many researchers in Australia employing FBDD.Read moreRead less
Mechanisms of antifungal resistance in blackleg disease of canola. This project aims to determine how fungicide resistance evolves in the fungus Leptosphaeria maculans, the major pathogen of the oilseed crop canola. Global food production has become more reliant on the use of antifungal agents to protect crops, however these advances are now threatened by the emergence of drug-resistant microbes. The knowledge generated by this project will be used to reduce the risk of resistance evolving in po ....Mechanisms of antifungal resistance in blackleg disease of canola. This project aims to determine how fungicide resistance evolves in the fungus Leptosphaeria maculans, the major pathogen of the oilseed crop canola. Global food production has become more reliant on the use of antifungal agents to protect crops, however these advances are now threatened by the emergence of drug-resistant microbes. The knowledge generated by this project will be used to reduce the risk of resistance evolving in populations of the blackleg fungus. This will have economic benefits through ensuring increased canola yields, while providing health and environmental benefits through minimisation of use of fungicides.Read moreRead less