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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989471
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Facility for innovation in structural biomaterials engineering. Biomaterials are used in a diverse range of environments that impact on the way that all Australians live. The Facility for Innovation in Structural Biomaterials Engineering will greatly assist researchers to undertake cross-disciplinary projects aimed at improving human health eg. smart materials that assist stem cell therapies for treating deafness and spinal cord injuries, as well the way we live eg. more durable building materia ....Facility for innovation in structural biomaterials engineering. Biomaterials are used in a diverse range of environments that impact on the way that all Australians live. The Facility for Innovation in Structural Biomaterials Engineering will greatly assist researchers to undertake cross-disciplinary projects aimed at improving human health eg. smart materials that assist stem cell therapies for treating deafness and spinal cord injuries, as well the way we live eg. more durable building materials for a sustainable national infrastructure. The facility will help Australia remain at the forefront of these high priority areas and see both individuals and industry benefit from advanced biomaterial products.Read moreRead less
Australia's Baby Boomer Generation, Obesity and Work - Patterns, Causes and Implications. In Australia's ageing crisis, baby boomers play a key role. Not only will they double the size of the aged population and its ratio to the workforce age group but the extent to which they remain in the workforce and their health will be crucial to future national productivity and prosperity. Baby Boomers have the highest level of obesity of any Australian age cohort and this threatens to seriously reduce ....Australia's Baby Boomer Generation, Obesity and Work - Patterns, Causes and Implications. In Australia's ageing crisis, baby boomers play a key role. Not only will they double the size of the aged population and its ratio to the workforce age group but the extent to which they remain in the workforce and their health will be crucial to future national productivity and prosperity. Baby Boomers have the highest level of obesity of any Australian age cohort and this threatens to seriously reduce their workforce participation and productivity and increase chronic disease incidence. There is a narrow closing window of opportunity for intervention which will reduce obesity and improve health and workforce outcomes.Read moreRead less
Proteomic analysis of subcellular changes during apoptosis. This project aims to use a novel proteomic approach to examine mechanisms of apoptosis at the level of the plasma membrane, mitochondrion, nucleus and cytosol, screening protein extracts of cell organelles by the new technique of SELDI-TOF mass spectrometry in which proteins are adsorbed onto activated chips. This will provide protein mass profiles characteristic of various stages of apoptosis, and will allow identification of proteins ....Proteomic analysis of subcellular changes during apoptosis. This project aims to use a novel proteomic approach to examine mechanisms of apoptosis at the level of the plasma membrane, mitochondrion, nucleus and cytosol, screening protein extracts of cell organelles by the new technique of SELDI-TOF mass spectrometry in which proteins are adsorbed onto activated chips. This will provide protein mass profiles characteristic of various stages of apoptosis, and will allow identification of proteins of interest by conventional proteomic methods. The establishment of SELDI-MS as a viable tool for cell proteomics would open new opportunities to understand a broad range of cellular functions at the level of protein expression.Read moreRead less
Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities ....Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities to address current limitations in understanding the stability of magnetic nanoparticles in biological fluids. The Australian partners will play a leading role in commercializing new applications for functionalized magnetic nanoparticles. The project will provide an excellent multidisciplinary research environment and training for early career researchers.Read moreRead less
Doing Bayesian Statistics Better: an Inter-Disciplinary Perspective for Improving Models, Priors, Design and Applications. Through improving methods for data analysis and design, this project increases the capability of individuals, communities and governments to make correct decisions based on data, leading to immeasurable human, social and financial benefits. It will also directly enhance Australia's international research reputation, promote inter-disciplinary links, promote research by wome ....Doing Bayesian Statistics Better: an Inter-Disciplinary Perspective for Improving Models, Priors, Design and Applications. Through improving methods for data analysis and design, this project increases the capability of individuals, communities and governments to make correct decisions based on data, leading to immeasurable human, social and financial benefits. It will also directly enhance Australia's international research reputation, promote inter-disciplinary links, promote research by women in a non-traditional area, keep intellectual property within Australia, train quality undergraduates and postgraduates, and contribute to public good through its focus on applications in key national priorities: health, environment and genetics. Read moreRead less
Emergency Health Services: Demand and service delivery models. Congestion of emergency health services is causing considerable community concern regarding Australia's capacity to manage daily health emergencies and to respond to major incidents and disasters. The service models developed in this project will provide the basis for policy and service initiatives which will address the growing demand for emergency health services more efficiently and effectively and thus meet community expectations ....Emergency Health Services: Demand and service delivery models. Congestion of emergency health services is causing considerable community concern regarding Australia's capacity to manage daily health emergencies and to respond to major incidents and disasters. The service models developed in this project will provide the basis for policy and service initiatives which will address the growing demand for emergency health services more efficiently and effectively and thus meet community expectations. Improved services will result in improved community health and wellbeing. This project will also develop the research capacity of Australia through training of key individuals who will lead future research and development of emergency health services in Australia.Read moreRead less
Bayesian statistical methods for enhancing evidence-based practice in Australia's hospitals. This project addresses Australia's national research priority of Promoting and Maintaining Good Health with the goal of Preventative Healthcare. Through enhanced capability in combining information from diverse sources for improved evidence-based decisions and true sharing of university and medical expertise, the project will enhance Australia's medical research and practice, align professional and comm ....Bayesian statistical methods for enhancing evidence-based practice in Australia's hospitals. This project addresses Australia's national research priority of Promoting and Maintaining Good Health with the goal of Preventative Healthcare. Through enhanced capability in combining information from diverse sources for improved evidence-based decisions and true sharing of university and medical expertise, the project will enhance Australia's medical research and practice, align professional and community expectations, utilise local medical information, and address national demands for quality science underpinning health decisions.
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Devising sophisticated computational comparative genomic analysis strategies for animal and plant genomes. Given the significance of comparative genomic analysis, this research proposal brings together Australian scientists with a track record in comparative genomic analysis, bioinformatics, molecular biology and statistics to work on consolidating a computational framework for comparative genomic analysis and investigating transcriptome data by capitalising on international collaborations and i ....Devising sophisticated computational comparative genomic analysis strategies for animal and plant genomes. Given the significance of comparative genomic analysis, this research proposal brings together Australian scientists with a track record in comparative genomic analysis, bioinformatics, molecular biology and statistics to work on consolidating a computational framework for comparative genomic analysis and investigating transcriptome data by capitalising on international collaborations and involvement. The outcomes of this research will be of benefit to the national community through technology transfer (such as the identification of novel and functional genomic non-coding sequences), training (in bioinformatics related activities) and national coordination (of bioinformatics activities).Read moreRead less
Probing JNK MAPK function with peptide inhibitors. It has generally been accepted that the JNK MAPK family of protein kinases is rapidly and potently activated following the exposure of mammalian cells to stresses and cytokines. However, their biological role has remained controversial. We believe that this problem reflects the lack of a generally applicable and specific JNK MAPK inhibitor. In this project we continue our characterisation of a small peptide inhibitor developed in our laboratori ....Probing JNK MAPK function with peptide inhibitors. It has generally been accepted that the JNK MAPK family of protein kinases is rapidly and potently activated following the exposure of mammalian cells to stresses and cytokines. However, their biological role has remained controversial. We believe that this problem reflects the lack of a generally applicable and specific JNK MAPK inhibitor. In this project we continue our characterisation of a small peptide inhibitor developed in our laboratories. We aim to determine its mechanism of inhibition, the specificity of interaction, and to evolve more effective inhibitors. With these new inhibitors, we can effectively address the biological roles of these kinases.Read moreRead less
Parasite virulence: the role of activation and suppression of P2X7 receptors. Toxoplasmosis and leishmaniasis pose a threat to the health and well-being of the Australian human and animal populations. Around 6-8 million Australians are infected with Toxoplasma, a parasite that can cause severe problems in immunosuppressed individuals and birth defects and miscarriage in pregnant women with a primary infection. Toxoplasmosis is also the main cause of abortion and stillbirth in Australian sheep. L ....Parasite virulence: the role of activation and suppression of P2X7 receptors. Toxoplasmosis and leishmaniasis pose a threat to the health and well-being of the Australian human and animal populations. Around 6-8 million Australians are infected with Toxoplasma, a parasite that can cause severe problems in immunosuppressed individuals and birth defects and miscarriage in pregnant women with a primary infection. Toxoplasmosis is also the main cause of abortion and stillbirth in Australian sheep. Leishmaniasis, recently found in Australia, is a risk for overseas travellers, livestock and wildlife. This research will provide an understanding of what makes these parasites successful, paving the way for development of novel drugs to combat these chronic diseases.Read moreRead less