Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346903
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
LC-MS system for Faculty of Sciences, U.N.E. LC-MS is a technique for investigating the composition of complex mixtures and identifying its components. This instrumentation will be utilised at UNE in a diverse range of analytical investigations to further the research aims of scientists in chemistry, biological sciences, archaeology, physics, environmental sciences, marine science as well as biological researchers in specialised units based at UNE. The extraordinarily versatile capacity of this ....LC-MS system for Faculty of Sciences, U.N.E. LC-MS is a technique for investigating the composition of complex mixtures and identifying its components. This instrumentation will be utilised at UNE in a diverse range of analytical investigations to further the research aims of scientists in chemistry, biological sciences, archaeology, physics, environmental sciences, marine science as well as biological researchers in specialised units based at UNE. The extraordinarily versatile capacity of this technique for analysis and identification of organic substances, from small molecules through to large proteins and complex plant and animal metabolites, will provide impetus for existing research and stimulus for new research directions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561041
Funder
Australian Research Council
Funding Amount
$347,358.00
Summary
A New Generation Biosensor and Fluorescence Facility for Proteomics. The complete DNA sequence (the genome) is now known for many organisms and advances are being made to identify the complement of messenger RNA (the transcriptome) and the resultant collection of proteins (the proteome). The genome is largely fixed while the transcriptome and proteome differ between cell types in an organism and constantly vary to adapt the cell to changing conditions. The mediators of these variations are prote ....A New Generation Biosensor and Fluorescence Facility for Proteomics. The complete DNA sequence (the genome) is now known for many organisms and advances are being made to identify the complement of messenger RNA (the transcriptome) and the resultant collection of proteins (the proteome). The genome is largely fixed while the transcriptome and proteome differ between cell types in an organism and constantly vary to adapt the cell to changing conditions. The mediators of these variations are proteins, interacting with each other and with signal molecules. The next frontier in molecular biology is to identify and quantify these protein interactions. Our two institutions have a very large cohort of biologists whose research on proteins would be greatly facilitated by the Biacore 3000 and the ISS K2.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668543
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples. Purchase of this equipment will support innovative and collaborative research addressing three of the National Research Priority areas. For example, defining novel drug delivery systems, or the chemical components present in Australia's bioresources, addresses 'Frontier technologies for building and transforming Australian industries', particularly the priority goals of breakthrough ....A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples. Purchase of this equipment will support innovative and collaborative research addressing three of the National Research Priority areas. For example, defining novel drug delivery systems, or the chemical components present in Australia's bioresources, addresses 'Frontier technologies for building and transforming Australian industries', particularly the priority goals of breakthrough science and frontier technologies. The research into trace components in food products, and on fruit fly chemistry, relates to National Research priority four 'Safeguarding Australia', with a priority goal of protecting Australia from invasive diseases and pests. Nutraceutical research addresses the goal of 'Promoting and maintaining good health'.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883036
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research. The expected benefits that will arise will include: green chemical processes with improved environmental and economic impacts; improved treatments and diagnoses of diseases; understanding of fundamental geological processes; identification of the earliest forms; studies of archaeological artefacts; evolution of life on Earth; the design of improved dental materials. Ultimatel ....Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research. The expected benefits that will arise will include: green chemical processes with improved environmental and economic impacts; improved treatments and diagnoses of diseases; understanding of fundamental geological processes; identification of the earliest forms; studies of archaeological artefacts; evolution of life on Earth; the design of improved dental materials. Ultimately, this research will include economic and social benefits in; industrial processes; the mining industry; medicine; and dentistry. An understanding of the origin and early evolution of life on Earth also has many social implications.Read moreRead less
Epigenetic integration of genomic and environmental information in honey bees. Environmental factors such as nutrition, drugs or childhood neglect alter gene activity without a change to the DNA code and may result in a range of conditions such as cancer, obesity and mental illness. Such epigenetic phenomena are driven by subtle and poorly understood modifications of the genome known as DNA methylation. Our aim is to study the link between DNA methylation and environmental influences. We aspire ....Epigenetic integration of genomic and environmental information in honey bees. Environmental factors such as nutrition, drugs or childhood neglect alter gene activity without a change to the DNA code and may result in a range of conditions such as cancer, obesity and mental illness. Such epigenetic phenomena are driven by subtle and poorly understood modifications of the genome known as DNA methylation. Our aim is to study the link between DNA methylation and environmental influences. We aspire to understand how environmental signals trigger the reprogramming of transcriptional control of genetic networks that lead to contrasting phenotypic and behavioural outcomes using the honey bee modelRead moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775590
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A single crystal X-ray diffractometer with CCD detector for structural analysis of small molecules. In recent years their have been major advances in the capacity of instrumentation to determine the crystal and molecular structure of chemical compounds and materials which in turn has resulted in a rapidly growing understanding of the relationship between the structure of molecules and their function in the design of new materials and as drugs for the treatment of disease and pain. This infrastr ....A single crystal X-ray diffractometer with CCD detector for structural analysis of small molecules. In recent years their have been major advances in the capacity of instrumentation to determine the crystal and molecular structure of chemical compounds and materials which in turn has resulted in a rapidly growing understanding of the relationship between the structure of molecules and their function in the design of new materials and as drugs for the treatment of disease and pain. This infrastructure also provides training of an international standard for undergraduate and post graduate students, thus building the skills capabilities of Australian scientists in the workforce.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560672
Funder
Australian Research Council
Funding Amount
$202,705.00
Summary
Ultrafast laser facility for chemical, biological and physical investigations of advanced materials. Ultrafast laser techniques are becoming indispensable in many diverse scientific disciplines. Within the Australian scientific community, there is a great need for enhanced access to sophisticated ultrafast laser instrumentation. The expansion to the femtosecond laser facility through the addition of state-of-the-art laser devices, will enable novel laser spectroscopy measurements and advanced op ....Ultrafast laser facility for chemical, biological and physical investigations of advanced materials. Ultrafast laser techniques are becoming indispensable in many diverse scientific disciplines. Within the Australian scientific community, there is a great need for enhanced access to sophisticated ultrafast laser instrumentation. The expansion to the femtosecond laser facility through the addition of state-of-the-art laser devices, will enable novel laser spectroscopy measurements and advanced optical microscopy techniques to be applied to investigations of advanced materials and biological systems. Access to such instrumentation is crucial to fields including photoluminescent conductive polymers, nanoparticles, engineered supramolecules for artificial photosynthetic systems, and photoactivated therapy and drug delivery/release technology.Read moreRead less
From Chemical Architecture to Protein Surfaces. Creation of small stable molecules that reproduce key functions of important protein surfaces, would be a significant technology breakthrough with many important potential applications in science, medicine & industry. As new scientific tools they could be used to interrogate biological systems & implicate specific protein surfaces in biological/disease mechanisms. As leads to new medicines (pharmaceuticals, vaccines, diagnostics), they could offer ....From Chemical Architecture to Protein Surfaces. Creation of small stable molecules that reproduce key functions of important protein surfaces, would be a significant technology breakthrough with many important potential applications in science, medicine & industry. As new scientific tools they could be used to interrogate biological systems & implicate specific protein surfaces in biological/disease mechanisms. As leads to new medicines (pharmaceuticals, vaccines, diagnostics), they could offer new ways of impacting on infection, diseases of the aged, & preventative medicine (National Research Priorities). As new intellectual property, the technology has the potential to advance basic science at the chemistry-biology interface while providing new economic opportunities for Australia.Read moreRead less
Intermolecular interactions revisited-Flaws in the fabric and applications to lower-dimensional structures. This project aims to capitalise on recent developments, that have shown that previously accepted theories are deeply flawed, in various applications in fundamental physics and in unsolved problems in biology that involve electromagnetic fields. Interactions driven
by electromagnetic fluctuation forces, and real photon exchange, between molecules will be investigated. The project will inv ....Intermolecular interactions revisited-Flaws in the fabric and applications to lower-dimensional structures. This project aims to capitalise on recent developments, that have shown that previously accepted theories are deeply flawed, in various applications in fundamental physics and in unsolved problems in biology that involve electromagnetic fields. Interactions driven
by electromagnetic fluctuation forces, and real photon exchange, between molecules will be investigated. The project will investigate how dispersion interactions change in mesoscopic pores, in electrolytes, and at finite temperatures. Applications involve
catalysis, molecular formation, and quantum logic. The project also aims to develop a unified theory for energy and charge transfer, relevant for photosynthesis and the way biological molecules transfer information.Read moreRead less