Vibrational Spectroscopy and Imaging from Interstellar Dust to Life. The outcome of this project will result in a more thorough understanding of the role of water in the atmosphere and in the Greenhouse effect, and will provide information leading to more accurate modelling of Global warming. The results will also lead to new insights into interstellar chemistry, the chemistry of cometary dust and the origins of life.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561233
Funder
Australian Research Council
Funding Amount
$434,000.00
Summary
State-of-the-Art Solid State Nuclear Magnetic Resonance Facility. This proposal seeks funds for the purchase and installation of a state-of-the-art 400 MHz Wide-Bore Solid-State NMR spectrometer. Research projects utilising this euipment will benefit from the ability to probe the structure of solid samples that are difficult to characterise in any other way. These materials represent advances in nanotechnology, new materials and will impact on the analysis of environmental contaminants in pota ....State-of-the-Art Solid State Nuclear Magnetic Resonance Facility. This proposal seeks funds for the purchase and installation of a state-of-the-art 400 MHz Wide-Bore Solid-State NMR spectrometer. Research projects utilising this euipment will benefit from the ability to probe the structure of solid samples that are difficult to characterise in any other way. These materials represent advances in nanotechnology, new materials and will impact on the analysis of environmental contaminants in potable water supplies, with a particular Australian focus on the identification of compounds formed as by-products during disinfection processes.
The upgraded facility will be the only one of its kind in Western Australia.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883036
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research. The expected benefits that will arise will include: green chemical processes with improved environmental and economic impacts; improved treatments and diagnoses of diseases; understanding of fundamental geological processes; identification of the earliest forms; studies of archaeological artefacts; evolution of life on Earth; the design of improved dental materials. Ultimatel ....Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research. The expected benefits that will arise will include: green chemical processes with improved environmental and economic impacts; improved treatments and diagnoses of diseases; understanding of fundamental geological processes; identification of the earliest forms; studies of archaeological artefacts; evolution of life on Earth; the design of improved dental materials. Ultimately, this research will include economic and social benefits in; industrial processes; the mining industry; medicine; and dentistry. An understanding of the origin and early evolution of life on Earth also has many social implications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560672
Funder
Australian Research Council
Funding Amount
$202,705.00
Summary
Ultrafast laser facility for chemical, biological and physical investigations of advanced materials. Ultrafast laser techniques are becoming indispensable in many diverse scientific disciplines. Within the Australian scientific community, there is a great need for enhanced access to sophisticated ultrafast laser instrumentation. The expansion to the femtosecond laser facility through the addition of state-of-the-art laser devices, will enable novel laser spectroscopy measurements and advanced op ....Ultrafast laser facility for chemical, biological and physical investigations of advanced materials. Ultrafast laser techniques are becoming indispensable in many diverse scientific disciplines. Within the Australian scientific community, there is a great need for enhanced access to sophisticated ultrafast laser instrumentation. The expansion to the femtosecond laser facility through the addition of state-of-the-art laser devices, will enable novel laser spectroscopy measurements and advanced optical microscopy techniques to be applied to investigations of advanced materials and biological systems. Access to such instrumentation is crucial to fields including photoluminescent conductive polymers, nanoparticles, engineered supramolecules for artificial photosynthetic systems, and photoactivated therapy and drug delivery/release technology.Read moreRead less
Single molecule spectroscopy of functional luminescent materials. This project will provide new insights into the light induced processes occurring in individual molecules of potentially useful luminescent materials. The molecules to be studied include new fluorescent probes of biological and polymer systems and single light harvesting nanoparticles with applications in solar energy collection and conversion. The program of work proposed will increase our understanding of light induced chemical ....Single molecule spectroscopy of functional luminescent materials. This project will provide new insights into the light induced processes occurring in individual molecules of potentially useful luminescent materials. The molecules to be studied include new fluorescent probes of biological and polymer systems and single light harvesting nanoparticles with applications in solar energy collection and conversion. The program of work proposed will increase our understanding of light induced chemical processes and assist the design of advanced materials for photomolecular devices.Read moreRead less
Microprobe and Nanoprobe Studies on Intracellular Disease Processes and Their Treatment. Breakthrough microprobe and nanoprobe technologies, involving X-ray, visible and infrared light can focus into different components of mammalian cells in order to interrogate the biochemistry that is occurring therein. Each of the different wavelengths of light provides complementary biochemical information that enables a deeper understanding of changes in cells that occur as a function of drug treatments an ....Microprobe and Nanoprobe Studies on Intracellular Disease Processes and Their Treatment. Breakthrough microprobe and nanoprobe technologies, involving X-ray, visible and infrared light can focus into different components of mammalian cells in order to interrogate the biochemistry that is occurring therein. Each of the different wavelengths of light provides complementary biochemical information that enables a deeper understanding of changes in cells that occur as a function of drug treatments and disease processes. This will provide unprecedented information as to where drugs go and how they are transformed inside cells that, in turn, may revolutionalise the way in which new drugs are designed that have higher specificity and fewer side effects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989127
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
A High-Throughput Neutron Spectrometer for The Study of Atomic and Molecular Motion at ANSTO. Neutron scattering enables new science across a broad range of disciplines, and for this reason it is undergoing major expansion in the USA, Europe, Japan and Australia. Various diffactometers and spectrometers have recently been built at ANSTO, but an instrumental option for a high-throughput cross-discipline spectroscopy is urgently needed. Fortunately, it is fairly straightforward to add this type of ....A High-Throughput Neutron Spectrometer for The Study of Atomic and Molecular Motion at ANSTO. Neutron scattering enables new science across a broad range of disciplines, and for this reason it is undergoing major expansion in the USA, Europe, Japan and Australia. Various diffactometers and spectrometers have recently been built at ANSTO, but an instrumental option for a high-throughput cross-discipline spectroscopy is urgently needed. Fortunately, it is fairly straightforward to add this type of option to an existing spectrometer that will broaden its user-base from specialised applications in physics to more general applications in physics, chemistry, materials-science and biology. This additional option provides a totally new way for Australian scientists to study atomic and molecular motions. Read moreRead less
Towards Nano-Assembled Light Emitting Polymer Films. Advanced materials constructed with molecular level architecture through controlled nano-assembly will benefit medical science, biotechnology and nanotechnology, communications and the electronics fields. The national research priorities of nanotechnology and advanced materials through nano-assembly will be promoted by this work. This research will assist Australian industries to further advance these processes and devices leading to better qu ....Towards Nano-Assembled Light Emitting Polymer Films. Advanced materials constructed with molecular level architecture through controlled nano-assembly will benefit medical science, biotechnology and nanotechnology, communications and the electronics fields. The national research priorities of nanotechnology and advanced materials through nano-assembly will be promoted by this work. This research will assist Australian industries to further advance these processes and devices leading to better quality, cheaper, more efficient products. The Australian community will benefit through economic and technological advances. These advanced materials will promote health and environmental wellbeing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560680
Funder
Australian Research Council
Funding Amount
$901,862.00
Summary
Vibrational Spectroscopy Microprobe/FESEM/AFM Imaging of Cells, Tissues and Materials. State-of-the-art vibrational mapping and imaging equipment (integrated with a field-emission scanning electron microscope (FESEM) and an atomic force microscope (AFM)) will provide enabling technologies for cutting-edge research in disease diagnosis, identification of pathogens, mapping of the entry and distribution of pharmaceutics into cells, and materials research. An InVia Renishaw Raman spectrometer (sub ....Vibrational Spectroscopy Microprobe/FESEM/AFM Imaging of Cells, Tissues and Materials. State-of-the-art vibrational mapping and imaging equipment (integrated with a field-emission scanning electron microscope (FESEM) and an atomic force microscope (AFM)) will provide enabling technologies for cutting-edge research in disease diagnosis, identification of pathogens, mapping of the entry and distribution of pharmaceutics into cells, and materials research. An InVia Renishaw Raman spectrometer (sub-micron spatial positioning and micron spatial resolution) will be interfaced to an FEI Quanta FESEM for combined Raman (spectroscopic), EDS and SEM (morphological) imaging/mapping at the sub-cellular level. Complementary new-generation Raman and IR spectrometer upgrades will provide an integrated world-class equipment platform.Read moreRead less
Raman and synchrotron spectroscopy of nano-scale drug interactions and molecular processes in single living cells. The need for potent low-cost drugs is ever increasing, yet effective ways to screen for new drugs remain elusive. A spectroscopic approach to screening drugs in living cells would seem a logical alternative to chemically based and morphological methods that are the status quo. In this context we are developing methodology to analyse molecular target sites in single living cells for ....Raman and synchrotron spectroscopy of nano-scale drug interactions and molecular processes in single living cells. The need for potent low-cost drugs is ever increasing, yet effective ways to screen for new drugs remain elusive. A spectroscopic approach to screening drugs in living cells would seem a logical alternative to chemically based and morphological methods that are the status quo. In this context we are developing methodology to analyse molecular target sites in single living cells for two of the most devastating diseases to afflict human kind, namely malaria and cancer. New ways of rapidly screening drugs in living cells prior to clinical trials will save an enormous amount of time, money and ultimately lives.Read moreRead less