Synthetic and theoretical studies of metal complexes containing carbon-rich ligands. Previous studies in my group, in conjunction with synthetic and theoretical chemistry groups at the Université de Rennes 1, France, have delineated the properties of a series of complexes containing carbon chains linking two metal centres. Having achieved a partial understanding of the features which result in good electronic communication between the metal centres via the carbon chain, the present proposal see ....Synthetic and theoretical studies of metal complexes containing carbon-rich ligands. Previous studies in my group, in conjunction with synthetic and theoretical chemistry groups at the Université de Rennes 1, France, have delineated the properties of a series of complexes containing carbon chains linking two metal centres. Having achieved a partial understanding of the features which result in good electronic communication between the metal centres via the carbon chain, the present proposal seeks to extend this collaboration to further studies which will generate related compounds in which actual eletron exchange can occur, i.e. leading to oxidation/reduction, by using compounds in which two or more different metal centres are present. This may lead to development of nano devices, e.g. molecular-scale switches. If one of the centres is activated by light, a photo-active sensor may result.Read moreRead less
The formation of negative ions and neutrals in the gas phase. Structure, reactivity and mechanism. Mass spectrometry is an analytical technique used to provide information concerning the structure of a chemical compound: it is particularly useful when dealing with small amounts of biologically important molecules. It is also a facility in which charged species can be converted into transient neutrals. This project will (i) produce information about negative ion fragmentations in order to extend ....The formation of negative ions and neutrals in the gas phase. Structure, reactivity and mechanism. Mass spectrometry is an analytical technique used to provide information concerning the structure of a chemical compound: it is particularly useful when dealing with small amounts of biologically important molecules. It is also a facility in which charged species can be converted into transient neutrals. This project will (i) produce information about negative ion fragmentations in order to extend the applicability of analytical negative-ion mass spectrometry, (ii) form neutral molecules and related species which are found in stellar dust clouds and investigate their chemistry, and (iii) train graduates in ion chemistry to the highest international standards.Read moreRead less
Nanotribology and Nanorheometry: A Fundamental Study of the Dynamic Interactions of Particles and Surfaces at the Molecular Level. Friction and deformation occur from the mutual motion and interaction of microscopic particles and surfaces. This research aims to develop new theories and measurement techniques for these non-equilibrium phenomena by combining mathematical analysis and numerical computations with dynamic force measurement, surface modification, and surface characterisation on nanom ....Nanotribology and Nanorheometry: A Fundamental Study of the Dynamic Interactions of Particles and Surfaces at the Molecular Level. Friction and deformation occur from the mutual motion and interaction of microscopic particles and surfaces. This research aims to develop new theories and measurement techniques for these non-equilibrium phenomena by combining mathematical analysis and numerical computations with dynamic force measurement, surface modification, and surface characterisation on nanometre and molecular length scales. These insights and data will be critically important in designing low-friction surfaces that save energy and wear, in developing nanoscopic probes for the mechanical and structural properties of soft polymeric and bio-materials, and in making high performance coatings that control adhesion and particle aggregation in technologically advanced applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668374
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies ....State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies and importantly, contribute to Australia's development as a knowledge-based economy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560658
Funder
Australian Research Council
Funding Amount
$481,533.00
Summary
Shared Laser Facility. The Australian Shared Laser Facility (ASLF) has been providing lasers for physical chemistry research for a decade. ASLF lasers are portable and are transported between participating laboratories according to need and research priorities. Funds are sought to expand the ASLF by 3 laser systems and 2 research groups. The requested lasers provide mid-IR and deep UV wavelengths, spectral regions inaccessible with existing ASLF lasers. Access to these wavelengths is essenti ....Shared Laser Facility. The Australian Shared Laser Facility (ASLF) has been providing lasers for physical chemistry research for a decade. ASLF lasers are portable and are transported between participating laboratories according to need and research priorities. Funds are sought to expand the ASLF by 3 laser systems and 2 research groups. The requested lasers provide mid-IR and deep UV wavelengths, spectral regions inaccessible with existing ASLF lasers. Access to these wavelengths is essential for Australian research to remain at the forefront of international physical chemistry research. ASLF laboratories support a wide range of chemical research including spectroscopy, environmental chemistry, astrochemistry, and exploration of nanostructured materials.Read moreRead less
Multifunctional mixed matrix membranes incorporating aligned carbon nanotubes. The pressure on water supplies in Australia will only increase in coming years meaning that effective and cheap means of recycling water must be found. By developing a carbon nanotube-based water filtration system, we intend to promote the growth of Australia's world-class reputation in water remediation. The technological outcomes from this research will lead to direct economic and environmental benefits for the comm ....Multifunctional mixed matrix membranes incorporating aligned carbon nanotubes. The pressure on water supplies in Australia will only increase in coming years meaning that effective and cheap means of recycling water must be found. By developing a carbon nanotube-based water filtration system, we intend to promote the growth of Australia's world-class reputation in water remediation. The technological outcomes from this research will lead to direct economic and environmental benefits for the community and offer commercial opportunities for industry. Training research scientists of the future forms an integral part of our program as it is crucial to maintain a critical mass in this potentially forthcoming water based economy.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0345760
Funder
Australian Research Council
Funding Amount
$210,000.00
Summary
Nanoscale Interaction Forces in Particulate and Molecular Systems. We seek to establish a world-class facility for the measurement of nanoscale interaction forces. The ability to measure forces between particles, polymers, emulsion droplets, bubbles, proteins and powders will augment our research capabilities in minerals and material processing, thin film technology, structured surfaces, and in molecular and bio-technology (eg. proteins, DNA, cells, bone, bio-implants). A Molecular Force Probe ....Nanoscale Interaction Forces in Particulate and Molecular Systems. We seek to establish a world-class facility for the measurement of nanoscale interaction forces. The ability to measure forces between particles, polymers, emulsion droplets, bubbles, proteins and powders will augment our research capabilities in minerals and material processing, thin film technology, structured surfaces, and in molecular and bio-technology (eg. proteins, DNA, cells, bone, bio-implants). A Molecular Force Probe (Asylum Research) instrument will allow precise and flexible force measurements on the nano-metre scale. The proposed multi-disciplinary facility will advance research in the areas of engineering, chemistry, pharmacology and biotechnology.
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Asymmetric Synthesis and Biological Evaluation of Bioactive Alkaloids and their Analogues. We propose to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The methodolo ....Asymmetric Synthesis and Biological Evaluation of Bioactive Alkaloids and their Analogues. We propose to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The methodology and products developed may have potential pharmaceutical and agricultural applications from which the country could benefit from in the future. This project would help developed skilled people that may develop innovative outcomes in the future, especially in the developing pharmaceutical and biotechnology industries in Australia.Read moreRead less
Engineered Nanotube Membranes for Molecular Separation and Biosensing. This broad research effort on the development of nanotube technology will provide potential applications not just in separation and biosensors but also in nanotechnology, biotechnology, drug delivery, energy storage, and catalysis. Development of advanced separation technologies and ultra sensitive biosensing devices based on functionalised gold nanotube membranes and low-cost fabrications are an important direction for Austr ....Engineered Nanotube Membranes for Molecular Separation and Biosensing. This broad research effort on the development of nanotube technology will provide potential applications not just in separation and biosensors but also in nanotechnology, biotechnology, drug delivery, energy storage, and catalysis. Development of advanced separation technologies and ultra sensitive biosensing devices based on functionalised gold nanotube membranes and low-cost fabrications are an important direction for Australian innovation in these fields. They will bring competitive advantages for further developments and applications for molecular separation and biomedical diagnostics. These research outcomes will enhance Australia's capacity in frontier technology and build strength in new analytical and separation technologies.Read moreRead less