Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989648
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Optical test-bed facility for mid infrared components for sensing, imaging and astrophotonics. This test facility will enable Australian researchers to validate optical components and technologies at wavelengths from 2.5 to 20 microns, that are crucial for a wide range of applications including biophotonics, sensing, imaging, defense, and astro-photonics. Technologies related to the Mid IR are
expected to have a significant impact on quality of life and global economy. It will enable Australi ....Optical test-bed facility for mid infrared components for sensing, imaging and astrophotonics. This test facility will enable Australian researchers to validate optical components and technologies at wavelengths from 2.5 to 20 microns, that are crucial for a wide range of applications including biophotonics, sensing, imaging, defense, and astro-photonics. Technologies related to the Mid IR are
expected to have a significant impact on quality of life and global economy. It will enable Australian researchers to achieve a major impact in many areas of Mid IR fundamental and applied science as well as industry sectors such as sensing, biophotonics, defence, health, bio-security and imaging. Read moreRead less
Intermolecular interactions revisited-Flaws in the fabric and applications to lower-dimensional structures. This project aims to capitalise on recent developments, that have shown that previously accepted theories are deeply flawed, in various applications in fundamental physics and in unsolved problems in biology that involve electromagnetic fields. Interactions driven
by electromagnetic fluctuation forces, and real photon exchange, between molecules will be investigated. The project will inv ....Intermolecular interactions revisited-Flaws in the fabric and applications to lower-dimensional structures. This project aims to capitalise on recent developments, that have shown that previously accepted theories are deeply flawed, in various applications in fundamental physics and in unsolved problems in biology that involve electromagnetic fields. Interactions driven
by electromagnetic fluctuation forces, and real photon exchange, between molecules will be investigated. The project will investigate how dispersion interactions change in mesoscopic pores, in electrolytes, and at finite temperatures. Applications involve
catalysis, molecular formation, and quantum logic. The project also aims to develop a unified theory for energy and charge transfer, relevant for photosynthesis and the way biological molecules transfer information.Read moreRead less
Electron and Positron Interactions with Bio-Molecules. This program of research will quantify reaction rates and elucidate reaction pathways for a range of important processes in our bodies involving ionising radiation. It will lead to a greatly improved understanding of positron and electron interactions with biological systems, including DNA and its constituent molecules and, through a better understanding of the underlying fundamental interactions, will lay foundations for improvements in te ....Electron and Positron Interactions with Bio-Molecules. This program of research will quantify reaction rates and elucidate reaction pathways for a range of important processes in our bodies involving ionising radiation. It will lead to a greatly improved understanding of positron and electron interactions with biological systems, including DNA and its constituent molecules and, through a better understanding of the underlying fundamental interactions, will lay foundations for improvements in technologies such as PET imaging. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0344441
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
New Generation Metalloenzyme Magnetic Circular Dichroism Spectrometer Systems. Funding is sought to enhance the existing collaborations between UQ, ANU, Sydney and other universities in the study of metal-centred molecules of biological interest through the construction of advanced magnetic circular dichroism (MCD) spectrometers. These facilities will be the best instruments of their kind, and will enable researchers at Australian institutions to enhance the quality of their research and remain ....New Generation Metalloenzyme Magnetic Circular Dichroism Spectrometer Systems. Funding is sought to enhance the existing collaborations between UQ, ANU, Sydney and other universities in the study of metal-centred molecules of biological interest through the construction of advanced magnetic circular dichroism (MCD) spectrometers. These facilities will be the best instruments of their kind, and will enable researchers at Australian institutions to enhance the quality of their research and remain internationally competitive through the application of modern MCD spectroscopic techniques to the study of metal-centred biomolecules. These facilities will drive a number of programs in the area of metalloenzyme and photosystem II research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237527
Funder
Australian Research Council
Funding Amount
$170,000.00
Summary
Bioscope IV : Advanced Scanned Probe Microscopy. The Atomic Force Microscope presents a unique view of the microscopic and molecular world, for it is sensitive to force alone. This instrument can accurately map force over a surface at the molecular scale; picoNewtons at nanometre resolution. The host of intermolecular forces which cause phenomena such as self-assembly, colloid stability, cell interactions and friction are only directly measurable with this technique. In this field of force meas ....Bioscope IV : Advanced Scanned Probe Microscopy. The Atomic Force Microscope presents a unique view of the microscopic and molecular world, for it is sensitive to force alone. This instrument can accurately map force over a surface at the molecular scale; picoNewtons at nanometre resolution. The host of intermolecular forces which cause phenomena such as self-assembly, colloid stability, cell interactions and friction are only directly measurable with this technique. In this field of force measurement Australian researchers are leaders. The proposed instrument expands the capabilities of this effort, and develops exciting new directions including the direct manipulation of molecules through a novel feedback and control (haptic) interface.Read moreRead less
ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membra ....ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membrane protein. We will develop techniques based on the latest developments in theoretical physics & chemistry, imaging, biology and technology - including the new Australian Synchrotron - to create new approaches to structural biology.Read moreRead less
Ionic Dispersion Forces in Physical Chemistry: Implications for pH, Electrochemistry, Nanoparticle Formation and Organic Synthesis. Our current understanding of charged systems in solution is deeply flawed . Existing theories are not predictive, mainly because they concentrate entirely on electrostatics. This proposal aims to partially rectify this by including the effects of previously neglected dispersion forces in a number of problems. These forces are responsible for much of the behaviou ....Ionic Dispersion Forces in Physical Chemistry: Implications for pH, Electrochemistry, Nanoparticle Formation and Organic Synthesis. Our current understanding of charged systems in solution is deeply flawed . Existing theories are not predictive, mainly because they concentrate entirely on electrostatics. This proposal aims to partially rectify this by including the effects of previously neglected dispersion forces in a number of problems. These forces are responsible for much of the behaviour seen in the following systems: the theory of electrolytes; electrochemistry pH and buffers; self energy effects in organic chemistry; and zeolite and nano-particle synthesis. The main outcome will be accurate and predictive theories for these systems.Read moreRead less
Macromolecular Condensates: From Globules to Toroids and Beyond. Polymers are long-chain molecules which are vital for all living things. Examples include proteins and DNA which carries all of the information needed for life. In the cell and in the laboratory these polymers are often found in a compact folded state. Current polymer science is good at describing very flexible polymers, but fails to describe most biological polymers which have backbones that are difficult to bend. Our aim is to ....Macromolecular Condensates: From Globules to Toroids and Beyond. Polymers are long-chain molecules which are vital for all living things. Examples include proteins and DNA which carries all of the information needed for life. In the cell and in the laboratory these polymers are often found in a compact folded state. Current polymer science is good at describing very flexible polymers, but fails to describe most biological polymers which have backbones that are difficult to bend. Our aim is to describe the folded or globular state for many kinds of biological polymers and thus improve our understanding of the role of polymers in living things.Read moreRead less