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Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities ....Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities to address current limitations in understanding the stability of magnetic nanoparticles in biological fluids. The Australian partners will play a leading role in commercializing new applications for functionalized magnetic nanoparticles. The project will provide an excellent multidisciplinary research environment and training for early career researchers.Read moreRead less
Covalent Hydrogen Bond Mimetics of Helical Peptide Hormones. Peptide hormones have been identified that adopt a helical shape when bound to their receptor. The project will produce new versions of these hormones by the use of directly bonded chemical linkers in place of the relatively weak helix hydrogen bonds. The resulting hormone mimics will be more stable, have lower molecular weight and be more selective than the natural hormones making them more suitable as drugs. Our new chemical techn ....Covalent Hydrogen Bond Mimetics of Helical Peptide Hormones. Peptide hormones have been identified that adopt a helical shape when bound to their receptor. The project will produce new versions of these hormones by the use of directly bonded chemical linkers in place of the relatively weak helix hydrogen bonds. The resulting hormone mimics will be more stable, have lower molecular weight and be more selective than the natural hormones making them more suitable as drugs. Our new chemical techniques allow us for the first time to fully investigate this approach which if successful will be applicable to many other helical peptides and therefore could be an important drug development technique.Read moreRead less
Graft copolymers from starch and synthetic monomers. Polymer dispersions, manufactured as latexes in large quantities in Australia and elsewhere, have myriad applications, such as in adhesives, bitumen modifiers, paints and paper coatings. This project will create the enabling science to replace by starch the current synthetic products used to stop these dispersions from coagulating. This will create new uses for renewable resources and will reduce environmental insult by avoiding the leaching o ....Graft copolymers from starch and synthetic monomers. Polymer dispersions, manufactured as latexes in large quantities in Australia and elsewhere, have myriad applications, such as in adhesives, bitumen modifiers, paints and paper coatings. This project will create the enabling science to replace by starch the current synthetic products used to stop these dispersions from coagulating. This will create new uses for renewable resources and will reduce environmental insult by avoiding the leaching of biologically incompatible chemicals. By using starch from crops suited for Australia's arid climate, the new technology will reduce both our dependence on imported products and our greenhouse gas emissions.Read moreRead less
Zirconium alloying and grain refinement of magnesium alloys with ZirCAST. Zirconium alloying and grain refinement is a key issue restricting the commercial production of value-added zirconium-containing magnesium alloys for use in the automotive industry. This 3-year linkage program builds on the applicants' invention of a proprietary grain refiner ZirCAST, and is undertaken to investigate the major fundamental aspects of zirconium alloying and grain refinement with ZirCAST. In addition to an ex ....Zirconium alloying and grain refinement of magnesium alloys with ZirCAST. Zirconium alloying and grain refinement is a key issue restricting the commercial production of value-added zirconium-containing magnesium alloys for use in the automotive industry. This 3-year linkage program builds on the applicants' invention of a proprietary grain refiner ZirCAST, and is undertaken to investigate the major fundamental aspects of zirconium alloying and grain refinement with ZirCAST. In addition to an excellent postgraduate training environment, it aims to provide and develop, in partnership with industry, optimum zirconium alloying and grain refinement technology with ZirCAST and enhance Australia's leading global position in this strategically and commercially important area.Read moreRead less
The flotation of oxide minerals using hydroxamate collectors. Australian and world mineral resources are declining in quality as we exploit the richest sulfidic ore deposits. This is increasing our reliance on concentration and beneficiation processes to improve the economics of the selective recovery of minerals from lower grade and, increasingly, oxide or lateritic ore bodies. In addition, greater emphasis is being placed on our environmental stewardship and the need to remove hazardous mater ....The flotation of oxide minerals using hydroxamate collectors. Australian and world mineral resources are declining in quality as we exploit the richest sulfidic ore deposits. This is increasing our reliance on concentration and beneficiation processes to improve the economics of the selective recovery of minerals from lower grade and, increasingly, oxide or lateritic ore bodies. In addition, greater emphasis is being placed on our environmental stewardship and the need to remove hazardous material from the concentrate streams. This proposal will develop improved methods and techniques that will facilitate better, cleaner separations and recovery of the valuable oxide mineral components using Australian-developed flotation reagents.Read moreRead less
CHARACTERISATION OF NOVEL BIOACTIVES FROM AUSTRALIAN HONEY WITH THERAPEUTIC POTENTIAL. Honey from specific Australian flowering plants has been identified that contain significant therapeutic properties in wound healing and other treatments. The research project proposed will identify and fully characterise the bioactive components of selected Australian honey (Medihoney) with antibiotic and growth promoting activites. These aims will be supported by high resolution mass spectrometry interfaced ....CHARACTERISATION OF NOVEL BIOACTIVES FROM AUSTRALIAN HONEY WITH THERAPEUTIC POTENTIAL. Honey from specific Australian flowering plants has been identified that contain significant therapeutic properties in wound healing and other treatments. The research project proposed will identify and fully characterise the bioactive components of selected Australian honey (Medihoney) with antibiotic and growth promoting activites. These aims will be supported by high resolution mass spectrometry interfaced with HPLC and or affinity chip surfaces, 750 MHz NMR analysis and a range of relevant bioassays on specific organisms and cell lines. These outcomes will not only enhance the value of current honey-based products but have the potential to identify new therapeutic lead molecules.Read moreRead less
Particle design and recovery of bioactives by crystallisation and precipitation. This project will develop new strategies for economically viable recovery of bioactives from complex solutions of biomaterials eg. separation of biopharmaceuticals from genetically engineered cell culture, food ingredient processing, functional food and nutraceutical extraction from natural sources. Crystallisation and precipitation will be used as primary separation techniques. We propose a new paradigm in which ....Particle design and recovery of bioactives by crystallisation and precipitation. This project will develop new strategies for economically viable recovery of bioactives from complex solutions of biomaterials eg. separation of biopharmaceuticals from genetically engineered cell culture, food ingredient processing, functional food and nutraceutical extraction from natural sources. Crystallisation and precipitation will be used as primary separation techniques. We propose a new paradigm in which molecular studies of protein interactions will be used to predict good crystallisation conditions and linked to process crystalliation studies. Studies will use a model system of egg white protein mixtures and a real system of industrial importance - the purification of valuable protein products from soy beans (valued at $500 million per year world wide). Soy beans studies will include pilot scale tests at Dupont's industrial reseach laboratories.Read moreRead less
Tailoring the microwave dielectric properties of promising electroceramics for use in wireless telecommunication components and devices. This project aims to develop and tailor the microwave dielectric properties of promising electroceramic materials specifically targeting next generation wireless telecommunications applications. The partnership between the ANU and the Australian company Microwave and Materials Designs has the potential to enable new microwave electroceramic materials to be disc ....Tailoring the microwave dielectric properties of promising electroceramics for use in wireless telecommunication components and devices. This project aims to develop and tailor the microwave dielectric properties of promising electroceramic materials specifically targeting next generation wireless telecommunications applications. The partnership between the ANU and the Australian company Microwave and Materials Designs has the potential to enable new microwave electroceramic materials to be discovered and then incorporated into new microwave components and/or devices developed in response to the requirements of the international wireless telecommunications market. The requested PhD student will gain experience in both the industrial and academic worlds and the skills needed to be part of Australia's high-tech workforce. Read moreRead less