Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100043
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Development of an ultra-high speed spinning disk confocal micro-particle image velocimetry (PIV) platform for the investigation of cardiovascular disease . This facility will establish a microscope system specifically designed to investigate the function of blood cells in the context of cardiovascular diseases such as heart attack and stroke.
Discovery Early Career Researcher Award - Grant ID: DE120102878
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Mobile phone text reminders to modify behaviours and prevent cardiovascular disease. Strategies are needed to improve adherence to behavioural and medical preventative treatments for heart disease. Brief informative reminders sent via mobile phone text message have potential as a cheap and safe method of improving behavioural change and adherence to treatments in people at risk of cardiovascular disease.
Benefits of blood pressure lowering to combat cardiovascular disease. Stroke and heart attack are the commonest causes of death and adult disability. In Australia, approximately 50,000 people die from cardiovascular disease each year. This project will attempt to prevent stroke/heart attack and to improve quality of life by exploring better management of high blood pressure.
Discovery Early Career Researcher Award - Grant ID: DE180100984
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Unravelling the cell biology of a blood vessel. This project aims to understand the molecular mechanisms of vascular regeneration in adult homeostasis. Maintaining a viable circulatory system is essential for organ survival and function. The data generated from this project has the capacity to significantly impact our fundamental understanding of cardiovascular repair and regeneration. This will be of future benefit to many industries including science, bioengineering, healthcare technologies, a ....Unravelling the cell biology of a blood vessel. This project aims to understand the molecular mechanisms of vascular regeneration in adult homeostasis. Maintaining a viable circulatory system is essential for organ survival and function. The data generated from this project has the capacity to significantly impact our fundamental understanding of cardiovascular repair and regeneration. This will be of future benefit to many industries including science, bioengineering, healthcare technologies, and ensuring significant economic outcomes and benefit the Australian community.Read moreRead less
Engineering layered double hydroxide nanoparticles toward an efficient targeted clinical delivery system. This project will develop a more effective drug delivery system using clay nanoparticles and biofriendly serum proteins. Outcomes from this project will provide a tremendous opportunity for potent therapies of cancers, vasculature and neuronal diseases, and place Australia at the forefront of nanotechnology drug delivery research.
Evaluation of peanuts as a source of bioactive nutrients for enhancement of endothelial function and cognitive performance. Functional foods represent one of the fastest growing food markets in the world, particularly foods which can offset adverse health conditions. The Partner Organisation, Peanut Company of Australia (PCA), is committed to developing peanut varieties, such as the high oleic peanut, that are nutritionally superior to the traditional varieties. By investing in research PCA aims ....Evaluation of peanuts as a source of bioactive nutrients for enhancement of endothelial function and cognitive performance. Functional foods represent one of the fastest growing food markets in the world, particularly foods which can offset adverse health conditions. The Partner Organisation, Peanut Company of Australia (PCA), is committed to developing peanut varieties, such as the high oleic peanut, that are nutritionally superior to the traditional varieties. By investing in research PCA aims to substantiate the nutritional benefits of these products and position itself in functional foods. Scientific evaluation of the health benefits that can be derived from consuming foods will enhance the national food industry through the growth of domestic and international licensing and export markets, and provide new employment opportunities in both rural and manufacturing sectors.Read moreRead less
Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledg ....Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledge and ideas as well as advanced research and industrial training for young scientists. Knowledge derived from this project is expected to enable future innovation in molecules with tailored interactions with the glycocalyx with significant benefits for researchers, manufacturers and end users. Read moreRead less
Imaging-based fluid-structure interaction modelling of carotid atherosclerotic plaque. This project aims to combine computational modelling, magnetic resonance imaging (MRI), mechanical measurement and pathological analysis to investigate carotid plaque progression, and quantify the critical blood flow and plaque stress/strain conditions under which plaque rupture is likely to occur. MRI-based 3D computational models with multi-component plaque structures and their interaction with blood flow wi ....Imaging-based fluid-structure interaction modelling of carotid atherosclerotic plaque. This project aims to combine computational modelling, magnetic resonance imaging (MRI), mechanical measurement and pathological analysis to investigate carotid plaque progression, and quantify the critical blood flow and plaque stress/strain conditions under which plaque rupture is likely to occur. MRI-based 3D computational models with multi-component plaque structures and their interaction with blood flow will be developed and solved numerically to identify suitable plaque rupture risk indicators. Mechanical properties of plaque components will be measured ex-vivo and fibre orientation-based constitutive rules will be developed. This project aims to lead to quantitative understandings of plaque progression and rupture.Read moreRead less
Understanding the role of methionine oxidation in amyloid formation. Amyloid deposition is associated with many debilitating systemic and neurological diseases, including Alzheimer's disease. This project aims to understand the effect of protein oxidation on the process of amyloid fibril formation. This knowledge will assist in the discovery of the triggers of these disorders and may identify methods of combating them.