Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100091
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
A five laser multichannel flow cytometry cell sorter for the University of New South Wales as part of an advanced flow cytometry network. Flow cytometry is a technique for counting and examining microscopic particles, such as cells and chromosomes, by suspending them in a stream of fluid and passing them by an electronic detection apparatus. This project will establish such advanced cell sorting instrumentation at the University of New South Wales, providing this capability to a wide range of re ....A five laser multichannel flow cytometry cell sorter for the University of New South Wales as part of an advanced flow cytometry network. Flow cytometry is a technique for counting and examining microscopic particles, such as cells and chromosomes, by suspending them in a stream of fluid and passing them by an electronic detection apparatus. This project will establish such advanced cell sorting instrumentation at the University of New South Wales, providing this capability to a wide range of researchers in diverse fields. The project will also provide a basis for establishing a flow cytometry network with partner institutes University of Sydney and the University of Technology, Sydney.Read moreRead less
Nuclear magnetic resonance (NMR) of molecules and cells in media with 'tunable' anisotropy: high rank-spins, z-spectra, (pro)chiral discrimination, peptide L-to-D isomerase. This project will build on this team's invention of a stretched-gel method that reports on molecular composition and the geometrical arrangement of atoms into mirror image arrays, using nuclear magnetic resonance spectroscopy. The project will use the methodology to determine roles of a platypus venom enzyme that carries out ....Nuclear magnetic resonance (NMR) of molecules and cells in media with 'tunable' anisotropy: high rank-spins, z-spectra, (pro)chiral discrimination, peptide L-to-D isomerase. This project will build on this team's invention of a stretched-gel method that reports on molecular composition and the geometrical arrangement of atoms into mirror image arrays, using nuclear magnetic resonance spectroscopy. The project will use the methodology to determine roles of a platypus venom enzyme that carries out stereoscopic interconversions, even in humans.Read moreRead less
Biomimetic blood bag materials for prolonged platelet storage. Platelet storage is limited to five to seven days before there is a reduction in viable platelets. This results in a continual mismatch between supply and demand resulting in patients in remotes areas or those that have rare phenotypes missing out on platelets. It also results in the wastage of platelets because they expire before they can be used clinically. This project aims to extend the platelet shelf life beyond seven days by de ....Biomimetic blood bag materials for prolonged platelet storage. Platelet storage is limited to five to seven days before there is a reduction in viable platelets. This results in a continual mismatch between supply and demand resulting in patients in remotes areas or those that have rare phenotypes missing out on platelets. It also results in the wastage of platelets because they expire before they can be used clinically. This project aims to extend the platelet shelf life beyond seven days by developing biomimetic blood bag materials that reflect the natural molecular structures of blood vessels through the use of novel synthetic and biological materials. With the realisation of longer platelet storage times, this project aims to have significant impacts on the health and economic benefits of Australians.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101635
Funder
Australian Research Council
Funding Amount
$343,450.00
Summary
DNA origami functionalised nanoscale surfaces. This project aims to combine the strengths of top-down and bottom-up nanofabrication to build hybrid structures. In traditional top-down nanofabrication, large systems pattern a semiconductor substrate to build up sophisticated devices. In contrast, in the emerging field of bottom-up nanotechnology, clever design of molecular interactions drives the self-assembly of smaller building blocks into more complex structures, with smaller features. This pr ....DNA origami functionalised nanoscale surfaces. This project aims to combine the strengths of top-down and bottom-up nanofabrication to build hybrid structures. In traditional top-down nanofabrication, large systems pattern a semiconductor substrate to build up sophisticated devices. In contrast, in the emerging field of bottom-up nanotechnology, clever design of molecular interactions drives the self-assembly of smaller building blocks into more complex structures, with smaller features. This project aims to bridge the gap between these two technologies to build functional devices. These devices will be applied, for example, to understand biological problems such as why blood clots form on implanted medical devices - their main cause of failure.Read moreRead less