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Fighting disease on farms: how do vaccinations drive evolution of new pathogen strains? Vaccinating against some types of infectious diseases can drive evolution of new variants of the pathogen. This project will show how bacterial populations evolve in response to vaccination in farms, leading to new vaccination strategies and improved vaccine formulations to better control diseases that are caused by highly variable bacteria.
Understanding fish-killing mechanisms by harmful algal blooms: towards the design of effective mitigation strategies. Fish-killing microalgal blooms cause multi-million dollar losses to global aquaculture and wild fisheries. This project brings together leading Australian and Canadian research teams, applying sophisticated cell line and biologically active molecule technologies, to elucidate precise fish-kill mechanisms and design effective mitigation strategies.
Revealing the determinants of viral emergence and evolution in fish. Viral diseases pose an ongoing threat to Australian aquaculture. The devastating impact of emerging viruses makes it imperative to understand the factors that allow them to evolve and infect new hosts. We will address these key issues by revealing the diversity, abundance and evolution of viruses in fish sampled along the Australian east coast. The data generated will reveal the untapped biodiversity of fish viruses, the freque ....Revealing the determinants of viral emergence and evolution in fish. Viral diseases pose an ongoing threat to Australian aquaculture. The devastating impact of emerging viruses makes it imperative to understand the factors that allow them to evolve and infect new hosts. We will address these key issues by revealing the diversity, abundance and evolution of viruses in fish sampled along the Australian east coast. The data generated will reveal the untapped biodiversity of fish viruses, the frequency which they jump species boundaries and the determinants of this process, and how they are impacted by host ecology, including whether fish viruses follow a latitudinal gradient in diversity. The data generated will transform our understanding of fish viruses and identify those most likely to impact aquaculture.Read moreRead less
Can consistent individual differences in metabolic rate explain animal personality? Implications for fish and aquaculture in a warming climate. This project will determine if consistent individual differences in metabolic rate affect behaviour, growth, and reproduction in fish. If so, then we need to prepare for the fact that a warming climate will lead to reductions in fish growth and reproduction, because rising temperature directly increases metabolism and therefore maintenance costs.
Characterisation of vital carbohydrate synthases in pathogenic oomycetes. This project aims to understand the mechanisms that control cell wall stability in the fish pathogen, Saprolegnia parasitica. The biochemical properties and function of vital enzymes involved in cell wall biosynthesis will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology, and structural biology. Next generation ion mobility mass spectrometry will be used to solve challe ....Characterisation of vital carbohydrate synthases in pathogenic oomycetes. This project aims to understand the mechanisms that control cell wall stability in the fish pathogen, Saprolegnia parasitica. The biochemical properties and function of vital enzymes involved in cell wall biosynthesis will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology, and structural biology. Next generation ion mobility mass spectrometry will be used to solve challenging structural questions that cannot be tackled with conventional techniques. Expected outcomes include new knowledge on challenging membrane proteins that allows development of novel strategies for disease control in aquaculture. The data may also be applicable to crop protection from related plant pathogens.Read moreRead less