Improving diagnostic accuracy and treatment options for equine PPID. Equine Pituitary Pars Intermedia Dysfunction (PPID) is a common, chronic and potentially life-threatening disease of older horses and ponies. Although a treatment is available, the disease is poorly understood and there are some concerns that the current diagnostic technology is not delivering accurate results. Thus, this project aims to develop a more accurate diagnostic test for PPID, while exploring the relationship between ....Improving diagnostic accuracy and treatment options for equine PPID. Equine Pituitary Pars Intermedia Dysfunction (PPID) is a common, chronic and potentially life-threatening disease of older horses and ponies. Although a treatment is available, the disease is poorly understood and there are some concerns that the current diagnostic technology is not delivering accurate results. Thus, this project aims to develop a more accurate diagnostic test for PPID, while exploring the relationship between PPID and metabolic syndrome, to generate new insights into the cause and consequences of both diseases. As an added benefit, the project will assist horseracing laboratories to improve their detection methods for peptide doping in younger competition horses.
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How brains become lateralised. This project aims to understand how the left and right sides of the brain become specialised for different cognitive functions, a phenomenon called lateralisation. Lateralisation is one of the least understood organisational principles of the brain, yet is crucial to the way we think and behave. Manifested most clearly as handedness, the brain is lateralised for many cognitive tasks such as language, reasoning, memory and emotion. However, the developmental origin ....How brains become lateralised. This project aims to understand how the left and right sides of the brain become specialised for different cognitive functions, a phenomenon called lateralisation. Lateralisation is one of the least understood organisational principles of the brain, yet is crucial to the way we think and behave. Manifested most clearly as handedness, the brain is lateralised for many cognitive tasks such as language, reasoning, memory and emotion. However, the developmental origin and anatomical substrate of most cognitive asymmetries are unknown. This project will use a chick model of brain lateralisation to quantify and localise to specific brain circuits the patterns of differential gene expression that give rise to anatomical and functional asymmetries.Read moreRead less
Novel semio-chemical approach to control the Australian Sheep Blowfly . The Australian Federal Government through the 'Smart Farming' initiative highlights the need for improved multidisciplinary measures in order to remain at the global forefront of the invention and adoption of technology. This multidisciplinary project (entomology, biotechnology, analytical chemistry and genomics) will rapidly inform the management of fly strike on an important Australian resource merino sheep. This will bui ....Novel semio-chemical approach to control the Australian Sheep Blowfly . The Australian Federal Government through the 'Smart Farming' initiative highlights the need for improved multidisciplinary measures in order to remain at the global forefront of the invention and adoption of technology. This multidisciplinary project (entomology, biotechnology, analytical chemistry and genomics) will rapidly inform the management of fly strike on an important Australian resource merino sheep. This will build the key biochemical data in order to develop a novel fly lure technology (at scale) to be used on farm delivering national benefit through improved animal welfare and safety considerations for producers, and will establish the best approach to disseminate this scientific information to stakeholders such as farmers.Read moreRead less
Targeting conjugated markers with new metabolomic methods. Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The in ....Targeting conjugated markers with new metabolomic methods. Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The intended outcome will be a set of sensitive and analytical methods using a range of newly identified conjugated steroid markers and associated reference materials, which promises to enhance integrity and animal welfare in the thoroughbred racing industry.
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Artificial intelligence algorithms to predict risk of injury in racehorses. This project will address the urgent need for predicting and preventing catastrophic and career limiting limb injuries and cardiac arrhythmias in racehorses due to over (or under) training. Using data from GPS and movement sensors integrated into saddlecloths, artificial intelligence algorithms will convert cumulative data on speed, gait, and stride characteristics during training, along with injury data, into a risk mat ....Artificial intelligence algorithms to predict risk of injury in racehorses. This project will address the urgent need for predicting and preventing catastrophic and career limiting limb injuries and cardiac arrhythmias in racehorses due to over (or under) training. Using data from GPS and movement sensors integrated into saddlecloths, artificial intelligence algorithms will convert cumulative data on speed, gait, and stride characteristics during training, along with injury data, into a risk matrix. Recorded heart rate and ECG data will also be analysed using artificial intelligence to detect early evidence of the development of cardiac arrhythmias. The system will improve racehorse welfare, providing a simple interface to warn trainers when risk of injury becomes high, in order to prevent catastrophic breakdown.Read moreRead less
Design of the cardiovascular system of living and fossil vertebrates. This project aims to understand how the heart and blood vessels evolved in mammals, birds, reptiles and fish to achieve efficiency. The heart is the most important organ for life. The project will study the structure and function of vertebrate animals’ hollow and spongy hearts to show how energetics shaped their evolution. It will measure arterial holes in bone to gauge brain and bone metabolism, which opens up a new way to me ....Design of the cardiovascular system of living and fossil vertebrates. This project aims to understand how the heart and blood vessels evolved in mammals, birds, reptiles and fish to achieve efficiency. The heart is the most important organ for life. The project will study the structure and function of vertebrate animals’ hollow and spongy hearts to show how energetics shaped their evolution. It will measure arterial holes in bone to gauge brain and bone metabolism, which opens up a new way to measure metabolism in extinct animals directly from fossils, rather than by inference from living relatives. The expected outcome is to correlate cardiovascular design and metabolic rates of organs.Read moreRead less
TSuNAMi: Time Series Network Animal Modelling. Our proposal is motivated by and based upon the successful representation of time series as a network (or graph). We construct an abstract representation of a system from measurements of its changing behaviour over time. Properties of that structure (the network) then allow us to infer diagnostic information of the system. Specifically, we propose to apply this to livestock welfare during transport. By measuring the biological and environment condi ....TSuNAMi: Time Series Network Animal Modelling. Our proposal is motivated by and based upon the successful representation of time series as a network (or graph). We construct an abstract representation of a system from measurements of its changing behaviour over time. Properties of that structure (the network) then allow us to infer diagnostic information of the system. Specifically, we propose to apply this to livestock welfare during transport. By measuring the biological and environment condition of the animal we construct a network representation of that system. Geometric features of that network can then be used to infer health or duress of the subject. This proposal will develop the generic mathematical machinery to connect geometric features of the network with system behaviour. Read moreRead less
Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an ....Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an animal health and production problem in the life of the commercial pig. This project will generate new knowledge on early life management to endow stress resilience in pigs, with expected benefits for animal welfare, farm productivity and profitability.Read moreRead less
Measuring pain in livestock: mechanisms, objective biomarkers and treatments. This project aims to create an objective blood test to measure pain in livestock, and to create a new drug treatment for persistent pain by targeting the immunology of the brain and spinal cord. This project expects to generate new knowledge of the involvement of the neuro-immune system in the creation and maintenance of persistent pain and how this can be quantified through the innovative use of peripheral blood tests ....Measuring pain in livestock: mechanisms, objective biomarkers and treatments. This project aims to create an objective blood test to measure pain in livestock, and to create a new drug treatment for persistent pain by targeting the immunology of the brain and spinal cord. This project expects to generate new knowledge of the involvement of the neuro-immune system in the creation and maintenance of persistent pain and how this can be quantified through the innovative use of peripheral blood tests. Expected outcomes of this project include a blood test capable of quantifying the extent of current pain experience, and a cumulative life measure of pain an animal has experienced. This should provide significant benefits to the Australian livestock industry by improving best practice.Read moreRead less
Sustaining chicken-meat production with alternative protein sources. This project aims to secure sustainable chicken-meat production by the radical reduction or even elimination of imported soybean meal as the primary protein source in Australian broiler diets by its replacement with feed-grade amino acids and local feedstuffs. This project will expand our comprehension of starch/glucose and protein/amino acid digestive dynamics in poultry diets based on wheat, the primary feed grain in Australi ....Sustaining chicken-meat production with alternative protein sources. This project aims to secure sustainable chicken-meat production by the radical reduction or even elimination of imported soybean meal as the primary protein source in Australian broiler diets by its replacement with feed-grade amino acids and local feedstuffs. This project will expand our comprehension of starch/glucose and protein/amino acid digestive dynamics in poultry diets based on wheat, the primary feed grain in Australia; however, wheat does inherently possess nutritional disadvantages. Expected outcomes include soybean meal-free feed formulations for the Australian chicken-meat industry to enhance the affordable and environmentally viable production of chicken-meat coupled with improved bird welfare and flock health. Read moreRead less