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Identifying novel insecticides and their targets: probing Australian arachnid venoms. Insect pests destroy an estimated 2-3 billion dollars of crops in Australia. Insect pests also are responsible for the transmission of many new and re-emerging human, animal and plant diseases threatening health, wellbeing and prosperity. Current insecticides are severely limited by toxicity and/or insect resistance, and some are undergoing use cancellation overseas. Thus there is an urgent need to develop safe ....Identifying novel insecticides and their targets: probing Australian arachnid venoms. Insect pests destroy an estimated 2-3 billion dollars of crops in Australia. Insect pests also are responsible for the transmission of many new and re-emerging human, animal and plant diseases threatening health, wellbeing and prosperity. Current insecticides are severely limited by toxicity and/or insect resistance, and some are undergoing use cancellation overseas. Thus there is an urgent need to develop safer and more specific insecticides that are effective against disease vectors and agricultural pest insects, as well as to identify new insecticide targets. This research has a multi-million dollar potential benefit to agricultural, health and pest control sectorsRead moreRead less
Porous Mineral Formulations for Controlled-Release Applications. The controlled release of biologically active agents from host materials is a process that is used routinely in pharmaceuticals delivery but has received only limited attention in large-scale, low-cost areas such as the agrochemicals industry. Here we identify a number of rare tubular mineral phases as having great potential for low-cost controlled release. These little-studied minerals, for which high quality deposits exist in Aus ....Porous Mineral Formulations for Controlled-Release Applications. The controlled release of biologically active agents from host materials is a process that is used routinely in pharmaceuticals delivery but has received only limited attention in large-scale, low-cost areas such as the agrochemicals industry. Here we identify a number of rare tubular mineral phases as having great potential for low-cost controlled release. These little-studied minerals, for which high quality deposits exist in Australia, consist of hollow tubules of nanoscale dimension. This project involves the first ever studies of the kinetics of guest release from these fascinating hosts, and promises to generate important new technologies in agrochemical delivery.Read moreRead less
Vibro-acoustic communication in termites. Termites can affect any Australian: one third of all Australian homes are likely to be infested by termites during their lifespan, costing a damage bill of A$780 million annually. Despite this level of damage, our understanding of the underlying foraging behaviour of termites is poor. Termites, being blind, cannot use visual cues and chemical cues are insufficient to explain observed phenomena. Our preliminary work has identified vibro-acoustic signal ....Vibro-acoustic communication in termites. Termites can affect any Australian: one third of all Australian homes are likely to be infested by termites during their lifespan, costing a damage bill of A$780 million annually. Despite this level of damage, our understanding of the underlying foraging behaviour of termites is poor. Termites, being blind, cannot use visual cues and chemical cues are insufficient to explain observed phenomena. Our preliminary work has identified vibro-acoustic signals used for information gathering and communication in foraging. The project aims to study vibro-acoustic mechanisms for communication in termite foraging behaviour. Anticipated outcomes include a significant impact on termite control.Read moreRead less
Domestication of blue-banded bees for greenhouse pollination. The tomato industry is currently shifting towards production in greenhouses, which allows climate control and improved pest management. A lack of pollinators is an obstacle to this move. This project will establish protocols for large-scale use of native blue-banded bees as pollinators in greenhouses, especially for tomatoes. Pollination by native bees increases fruit weight by 15%, comparable to the effects of bumblebees used overs ....Domestication of blue-banded bees for greenhouse pollination. The tomato industry is currently shifting towards production in greenhouses, which allows climate control and improved pest management. A lack of pollinators is an obstacle to this move. This project will establish protocols for large-scale use of native blue-banded bees as pollinators in greenhouses, especially for tomatoes. Pollination by native bees increases fruit weight by 15%, comparable to the effects of bumblebees used overseas. Significant economic, environmental and health benefits are expected from this project. The outcome will satisfy an industry need and remove an environmental threat by finding indigenous substitutes for alien bumblebees.Read moreRead less
Understanding and changing the mechanism of an enzyme: converting a peptidase to a phosphotriesterase. Enzymes have the ability to catalyse biological reactions rapidly as a consequence of their unique three-dimensional structures. We seek to define the structures of a family of metalloenzymes that are required in most living organisms to activate hormones, degrade unwanted proteins or recycle the protein building blocks for further synthesis. We shall use this information to enhance a second ....Understanding and changing the mechanism of an enzyme: converting a peptidase to a phosphotriesterase. Enzymes have the ability to catalyse biological reactions rapidly as a consequence of their unique three-dimensional structures. We seek to define the structures of a family of metalloenzymes that are required in most living organisms to activate hormones, degrade unwanted proteins or recycle the protein building blocks for further synthesis. We shall use this information to enhance a second function of these enzymes, namely their ability to break down organophosphorus-containing insecticides and nerve agents. Ultimately, the structural information resulting from this project may be used in drug design to regulate blood pressure and in engineering proteins for bioremediation.Read moreRead less
Nanostructured liquid crystal particles as Next Generation agricultural bioactive delivery systems. Improving the efficiency of use of agricultural chemicals, through utilization of novel liquid crystalline carriers particles, will deliver significant environmental and economic benefits. Reduced overall usage and input of chemicals into the environment, together with lower water consumption in the treatment of crops will contribute to an Environmentally Sustainable Australia, with benefits in re ....Nanostructured liquid crystal particles as Next Generation agricultural bioactive delivery systems. Improving the efficiency of use of agricultural chemicals, through utilization of novel liquid crystalline carriers particles, will deliver significant environmental and economic benefits. Reduced overall usage and input of chemicals into the environment, together with lower water consumption in the treatment of crops will contribute to an Environmentally Sustainable Australia, with benefits in reduced salinity. More economical farming will also lead to flow on benefits to other businesses in rural communities. The project will also enhance Australia's reputation in the uptake of nanotechnologies, and in training of young scientists in the nanotechnology field.Read moreRead less
Application of nano-sized zero valent iron particles to agrochemicals degradation through Fenton's reagent oxidation. Zero-valent iron (ZVI) has been successfully used for the degradation of a wide range of contaminant organics in groundwaters in recent years. The rates of degradation however are relatively slow and render the process unsuitable for situations where there are limits on the time available for reaction. An innovative approach is to couple the dissolution of ZVI with hydrogen perox ....Application of nano-sized zero valent iron particles to agrochemicals degradation through Fenton's reagent oxidation. Zero-valent iron (ZVI) has been successfully used for the degradation of a wide range of contaminant organics in groundwaters in recent years. The rates of degradation however are relatively slow and render the process unsuitable for situations where there are limits on the time available for reaction. An innovative approach is to couple the dissolution of ZVI with hydrogen peroxide addition thereby generating hydroxyl radicals as a result of Fenton's reagent reactions. The efficacy of using this innovative ZVI/H2O2 process to degrade herbicides and pesticides of concern to Australian agriculture is investigated at laboratory and field scale in this project.Read moreRead less
Marine Natural Products as Sources of Agrochemicals - The Variolins. The aim of this project is the identification of new classes of agrochemicals with better pest resistance and environmental profiles. The proposed partnership with a major international chemical manufacturing organization will allow access to state-of-the-art techniques for the screening and development of novel compounds as agents for the control of pests that affect many major agricultural crops relevant to Australia's econo ....Marine Natural Products as Sources of Agrochemicals - The Variolins. The aim of this project is the identification of new classes of agrochemicals with better pest resistance and environmental profiles. The proposed partnership with a major international chemical manufacturing organization will allow access to state-of-the-art techniques for the screening and development of novel compounds as agents for the control of pests that affect many major agricultural crops relevant to Australia's economy. Australian graduate students will experience the operations of one of the world's biggest chemical manufacturers. The derivation of agrochemicals from marine sources will promote further recognition of the value of marine ecosystems around Australia.Read moreRead less
Mechanistic and probabilistic approaches to assessing the impact of pesticide mixtures in Australian waterways. This project will provide vital information on the impacts of pesticide mixtures in Australian waterways and will also provide information with respect to safe levels of pesticides for water quality management. This information will be used to develop scientifically sound management policies and provide advice to regulatory authorities such as the NSW Department of Environment and Cons ....Mechanistic and probabilistic approaches to assessing the impact of pesticide mixtures in Australian waterways. This project will provide vital information on the impacts of pesticide mixtures in Australian waterways and will also provide information with respect to safe levels of pesticides for water quality management. This information will be used to develop scientifically sound management policies and provide advice to regulatory authorities such as the NSW Department of Environment and Conservation and the Federal Department of Environment and Heritage. Specifically the results will contribute to ensuring the use of pesticides in market gardens close to Sydney does not threaten the health of local rivers. Read moreRead less
Enhanced efficiency fertilisers for agricultural sustainability and environmental quality. Expected benefits will come from reduced environmental impact and improved profitability of farming. These include: demonstrably reduced emissions of nitrogen gases (nitrous oxide (a greenhouse gas), nitric oxide (ozone active), and ammonia (a pollutant and secondary greenhouse gas); less nitrate leaching, soil acidification and nitrogen contamination of water resources; increased flexibility in timing and ....Enhanced efficiency fertilisers for agricultural sustainability and environmental quality. Expected benefits will come from reduced environmental impact and improved profitability of farming. These include: demonstrably reduced emissions of nitrogen gases (nitrous oxide (a greenhouse gas), nitric oxide (ozone active), and ammonia (a pollutant and secondary greenhouse gas); less nitrate leaching, soil acidification and nitrogen contamination of water resources; increased flexibility in timing and method of fertiliser application; reduced requirement for nitrogen fertiliser, and; helping farmers adapt to future climatic and elevated CO2 conditions. These outcomes will significantly improve and help protect the future financial and environmental conditions of rural Australia, and improve our national greenhouse account. Read moreRead less