Neurotrophic factors for pelvic autonomic neurons: the role of neurturin. This project is about pelvic parasympathetic neurons, which are responsible for involuntary activities such as bladder voiding and penile erection. We are interested in the neurotrophic factors that determine survival of these neurons during early mammalian development and keep them healthy in adults. Little is known about ?parasympathetic neurotrophic factors? in general. However we have recently discovered that the prote ....Neurotrophic factors for pelvic autonomic neurons: the role of neurturin. This project is about pelvic parasympathetic neurons, which are responsible for involuntary activities such as bladder voiding and penile erection. We are interested in the neurotrophic factors that determine survival of these neurons during early mammalian development and keep them healthy in adults. Little is known about ?parasympathetic neurotrophic factors? in general. However we have recently discovered that the protein neurturin is very important in the pelvic parasympathetic system. We will determine exactly how neurturin affects pelvic neurons and how it interacts with other neurotrophic factors. Our results will fill a major gap in our knowledge of fundamental neurobiology.Read moreRead less
Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Comprehending and modelling the workings of the animal brain. Truly understanding how the brain operates is a grand challenge of 21st century neuroscience. Progress toward this goal can be made through studying small-brained animals, like the honey bee. This project aims to use microscopy and pharmacology to analyse the neural mechanisms by which bees learn and classify complex things. This will enable the construction of a computational model of decision making in the bee brain. Analysing this ....Comprehending and modelling the workings of the animal brain. Truly understanding how the brain operates is a grand challenge of 21st century neuroscience. Progress toward this goal can be made through studying small-brained animals, like the honey bee. This project aims to use microscopy and pharmacology to analyse the neural mechanisms by which bees learn and classify complex things. This will enable the construction of a computational model of decision making in the bee brain. Analysing this model will test what is understood about the operation of the animal brain, and what simulates it. This project aims to reveal how neural circuits make complex decisions; establish key principles and foundational studies for comprehending larger more complex brains, and yield new approaches to machine learning.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100103
Funder
Australian Research Council
Funding Amount
$459,674.00
Summary
Fortifying animal and plant germ cells against proteotoxic stress. Cellular stress is responsible for widespread inefficiencies in plant and animal reproduction. Using high resolution proteomics and cryo-electron microscopy, this project aims to investigate how plant and animal germ cells respond to environmental stresses that are known to disrupt fertility, and assess two novel strategies to decrease the sensitivity of cells to stress. This project is expected to generate new global knowledge i ....Fortifying animal and plant germ cells against proteotoxic stress. Cellular stress is responsible for widespread inefficiencies in plant and animal reproduction. Using high resolution proteomics and cryo-electron microscopy, this project aims to investigate how plant and animal germ cells respond to environmental stresses that are known to disrupt fertility, and assess two novel strategies to decrease the sensitivity of cells to stress. This project is expected to generate new global knowledge in the area of fertility regulation with the potential to improve the tolerance of crop species to heat stress, prevent economic losses and help to secure future food production. Further, this project has the intended benefit of improving the fertility of animal species that suffer from stress-induced infertility.
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Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm. Fizzy-Related is a gene that appears to be essential in making an ovulated egg, and it may also have an important role to play in making sperm. A mouse knockout will be generated to examine exactly how it functions; because it affects the egg number remaining in the ovary and egg quality Fizzy-Related may be eventually an important therapeutic target.
Discovery Early Career Researcher Award - Grant ID: DE190101338
Funder
Australian Research Council
Funding Amount
$373,711.00
Summary
Building your future: builder-building coevolution in animal architectures. This project aims to reconstruct how animal architectures change throughout time and how this affects body shapes and functions of their builders. By clarifying the biological role of building behaviour this project will assist in predicting long term responses of wildlife, ecosystems and human life to a changing environment. The project expects to be achieved by comparing the structure, assembly and mechanical performan ....Building your future: builder-building coevolution in animal architectures. This project aims to reconstruct how animal architectures change throughout time and how this affects body shapes and functions of their builders. By clarifying the biological role of building behaviour this project will assist in predicting long term responses of wildlife, ecosystems and human life to a changing environment. The project expects to be achieved by comparing the structure, assembly and mechanical performance of animal architectures with animal morphology and performance in a global phylogenetic framework. This is critical for strategic planning of wildlife and landscape management.Read moreRead less
The link between the angiogenesis of live birth and cancer: a lizard model. The possible link between live birth and cancer will be tested in this project. Lizards that express a growth factor that helps the growth of human cancer tumours will be studied to determine the action of the factor in a whole animal and in human cancer cells.
Silicon defences for plant protection. This project aims to study how silicon uptake in grasses affects plant susceptibility aboveground. Grasses contain more silicon than nearly any other plant, which they acquire entirely from the soil. Silicon increases plant resistance to herbivores, disease and drought, but up to 25 per cent of grass productivity is lost to root herbivores, a situation compounded by water stress. Silicon uptake is poorly understood, but root herbivory and changing rainfall ....Silicon defences for plant protection. This project aims to study how silicon uptake in grasses affects plant susceptibility aboveground. Grasses contain more silicon than nearly any other plant, which they acquire entirely from the soil. Silicon increases plant resistance to herbivores, disease and drought, but up to 25 per cent of grass productivity is lost to root herbivores, a situation compounded by water stress. Silicon uptake is poorly understood, but root herbivory and changing rainfall patterns can either impair uptake or induce the plant to take up more silicon. The goal of this project is to optimise silicon-based resistance in grasses and exploit this for plant protection from invasive pests and drought.Read moreRead less
How brains become lateralised. This project aims to understand how the left and right sides of the brain become specialised for different cognitive functions, a phenomenon called lateralisation. Lateralisation is one of the least understood organisational principles of the brain, yet is crucial to the way we think and behave. Manifested most clearly as handedness, the brain is lateralised for many cognitive tasks such as language, reasoning, memory and emotion. However, the developmental origin ....How brains become lateralised. This project aims to understand how the left and right sides of the brain become specialised for different cognitive functions, a phenomenon called lateralisation. Lateralisation is one of the least understood organisational principles of the brain, yet is crucial to the way we think and behave. Manifested most clearly as handedness, the brain is lateralised for many cognitive tasks such as language, reasoning, memory and emotion. However, the developmental origin and anatomical substrate of most cognitive asymmetries are unknown. This project will use a chick model of brain lateralisation to quantify and localise to specific brain circuits the patterns of differential gene expression that give rise to anatomical and functional asymmetries.Read moreRead less
Molecular identification of blowflies of forensic importance and thermal effects on their behaviour: tools to enhance forensic entomology in Australia. In suspicious deaths in which a body is found three or more days post-mortem, carrion-breeding blowflies provide time since death estimates. These estimates are currently slow and relatively broad due to (a) an inability to adequately distinguish immatures morphologically, and (b) insufficient information on the biological responses of different ....Molecular identification of blowflies of forensic importance and thermal effects on their behaviour: tools to enhance forensic entomology in Australia. In suspicious deaths in which a body is found three or more days post-mortem, carrion-breeding blowflies provide time since death estimates. These estimates are currently slow and relatively broad due to (a) an inability to adequately distinguish immatures morphologically, and (b) insufficient information on the biological responses of different species to temperature. We will develop rapid molecular assays to distinguish blowfly species, and comprehensively chart the behavioural effects of temperature on the most forensically important blowflies. Molecular and adult morphological data will also be used to examine the evolution of the carrion-breeding blowflies.Read moreRead less