Dynamic ocular imaging: New tools to study neurodegenerative disease. Neurovascular uncoupling occurs when blood supply and energy production is no longer responsive to the metabolic of nervous tissue. Neurovascular uncoupling is thought to be a key mechanism in the development of debilitating neurodegenerative diseases such as Alzheimer’s disease and glaucoma. This project will be the first study to develop, validate and employ a comprehensive suite to simultaneously image blood flow, oxygen sa ....Dynamic ocular imaging: New tools to study neurodegenerative disease. Neurovascular uncoupling occurs when blood supply and energy production is no longer responsive to the metabolic of nervous tissue. Neurovascular uncoupling is thought to be a key mechanism in the development of debilitating neurodegenerative diseases such as Alzheimer’s disease and glaucoma. This project will be the first study to develop, validate and employ a comprehensive suite to simultaneously image blood flow, oxygen saturation, metabolic activity and retinal function to understand neurovascular uncoupling in aging and age-related neurodegeneration. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101931
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Functional imaging with cellular resolution in the living eye. Adaptive optics allows the visualisation of individual cells and capillaries in the living human eye. This project will use adaptive optics to explore the normal function of these microscopic objects, and how this function changes in eyes suffering from disease. This will aid in developing new ways to diagnose and treat debilitating eye diseases.